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Biomedical subjects

F Schmid

Publications and source records attributed to F Schmid.

At least 37 records · Page 2Linked to original sources
PubMed1993

The Maquet procedure in the treatment of patellofemoral osteoarthrosis. Long-term results.

Long-term results are reported for 35 knees with patellofemoral osteoarthrosis treated by Maquet procedure. Eighty percent were rated very good or good, and 20% fair or poor. The poor results are attributed to errors in the diagnosis or to inadequate surgical technique. The Maquet procedure thus provides good results for painful knees with patellofemoral osteoarthrosis. A tibial tubercle elevation of at least 2 cm is necessary to decrease joint pressure sufficiently.

Adult↗
PubMed1992

Modulation of in vitro cell growth of human and murine urothelial tumor cell lines under the influence of interleukin-3, granulocyte-, macrophage- and granulocyte-colony-stimulating factor.

To elucidate possible growth-modulating effects of interleukin 3 (IL-3), granulocyte-macrophage-colony-stimulating factor (GM-CSF) and granulocyte-colony-stimulating factor (G-CSF), human transitional cell carcinoma (TCC) cell lines T24, RT112, EJ and 647 V were solitarily and continuously exposed to these hematopoietic growth factors at concentrations of 1-100 ng/ml. The murine line MBT-2 was used as a negative and the colon carcinoma cell line HTB38 as a positive control, because of species specificity and known proliferation in response to growth factors, respectively. In the T24 TCC-line solitary and continuous exposure to IL-3, GM-CSF and G-CSF at the highest concentration of 100 ng/ml led to a significant proliferation of cell growth in vitro. Significant proliferation in the RT112 line was only achieved with continuous exposure to IL-3 and GM-CSF (100 ng/ml); G-CSF failed to induce growth modulation in the RT112 line. No significant proliferative effect of any of cytokines administered was observed in the 647V line. Exposure of the EJ line to cytokines at the highest activity levels had a proliferative effect only in suboptimal growth conditions.

Adenocarcinoma↗
PubMed1991

[Habitual dislocation of the elbow in children].

After a short review on literature the late result of an operated elbow with a follow-up time of 23 years is reported. The actual problems of this rare condition are discussed. Congenital hyperlaxity, a shallow semilunar notch and traumatic sequelae after previous dislocations reduce joint stability. Arthroscopy, X-ray tomography and MRI update accurate preoperative diagnosis. Early operation is recommended to reduce further damage in the joint. Nowadays well proved operative procedures provide good postoperative results.

Adolescent↗
PubMed1991

[Risk of fracture of regenerated bone and metal implant following bone lengthening osteotomy].

Many problems may arise, jeopardize and spoil the outcome of lengthening osteotomies. Fracture of the plate and the newly formed bone bridging the gap between the fragments is only one of the possible complications. Overload is its cause in all the cases. Following the theory of Pauwels the paper analyses the high stresses in hollow bone and the relationship to their principles of construction. Accurate knowledge of bone stressing and correct assessment of bone strength in the X-rays may help to reduce the incidence of fatigue fractures after limb lengthening.

Bone Lengthening↗
PubMed1991

Randomized comparison of flecainide and cibenzoline in the conversion of atrial fibrillation.

The efficacy of oral cibenzoline (260 mg/day and 320 mg/day) and flecainide (200 mg/day and 300 mg/day) in the conversion of chronic atrial fibrillation to sinus rhythm were compared in 31 patients in a randomized order. If sinus rhythm was not restored on the 5th day of oral treatment with either cibenzoline or flecainide (phase of initial treatment) patients were switched to a second phase of treatment with the drug not given in the first phase after a washout phase of 3 days. Sinus rhythm was restored in 7/28 treatment trials with cibenzoline and in 7/23 treatment trials with flecainide (not significant). Trough levels of cibenzoline and flecainide in the plasma were not significantly different between patients in whom sinus rhythm was restored and patients with persisting atrial fibrillation. In patients successfully converted to sinus rhythm, long-term treatment was instituted with flecainide (n = 6) or cibenzoline (n = 6). Atrial fibrillation developed in 2 patients in each group of patients within 3 months. In all other patients, sinus rhythm was maintained during the follow-up period of 12 months. Non-cardiac side effects were observed in 2 patients during treatment with cibenzoline and flecainide respectively. With flecainide, one patient developed sinus arrest up to 5.6 seconds.

Adult↗
PubMed1990

Effects of intravenous cibenzoline on ventricular vulnerability and electrophysiology in patients with sustained ventricular tachycardia in comparison to a control group.

The electrophysiologic effects of intravenous (i.v. 1.5 mg/kg) cibenzoline were investigated in 13 patients with organic heart disease and supraventricular arrhythmias (control group) and 13 patients with drug refractory sustained ventricular tachycardia (VT group). In both groups, cibenzoline increased the effective refractory period (ERP) of the right ventricle (p less than or equal to 0.05), QRS duration (p less than or equal to 0.01), and QTc duration (p less than or equal to 0.01). Cycle length of the VT was increased from 311 +/- 73 to 393 +/- 119 ms (p less than or equal to 0.05) as well. The increase in QTc duration was more pronounced (p less than or equal to 0.05) in the VT group as compared with the control group. In four patients in the VT group with the largest increase in QRS-, QTc duration and cycle length of the VT proarrhythmia was noted after i.v. cibenzoline. Cibenzoline plasma levels were not significantly different between the two study groups. In the VT group, induction of VT was prevented in 2 patients, more difficult in 2 patients, easier in 1 patient, and unchanged in 5 patients. Spontaneous occurrence of the VT or induction by atrial stimulation was noted in 4 patients. In the control group, ventricular vulnerability remained unchanged. Cibenzoline may be effective in selected patients with drug refractory VT. In such patients, the increase in QTc duration was more pronounced as compared with a control group.

Anti-Arrhythmia Agents↗
PubMed1989

Continuous monitoring of mixed venous oxygen saturation in infants after cardiac surgery.

Continuous mixed venous oxygen saturation (SvO2c) was measured in 16 infants immediately after cardiac surgery. A polyurethane 4F, dual channel catheter (Opticath, Modell U440, Oximetrix) with fiberoptic filaments was introduced into the pulmonary artery during cardiothoracic surgery. The catheters were left in place for an average of 67.5 h (range 27 h -125 h) and there were no catheter-related complications. Correlation between continuous in vivo SvO2 values and in vitro values was satisfactory (r = 0.85), whereas a correlation between SvO2c and arterial oxygen saturation (SaO2) was not found (r = 0.07). The sampled arterial lactate values were inversely correlated to the simultaneously measured SvO2c, but the correlation coefficient was only r = -0.4. There was an inverse correlation between SvO2c and arteriovenous oxygen content difference (Ca-vDO2) (r = -0.82), and a marked inverse correlation to the calculated oxygen utilization ratio (r = -0.97). Therefore SvO2c continuously reflects the overall balance between oxygen consumption and delivery, but the use of SvO2 as a predictor of blood lactate levels is unreliable. A further purpose of the present study was to demonstrate the clinical applications and to show the usefulness of SvO2c-monitoring; particularly as a surveillance and early warning system, as a guide for assessing therapy and its relevance in interpreting other monitored parameters. In our opinion continuous SvO2 measurement is a reliable and valuable indicator of cardiopulmonary function in the immediate post-operative period, even in infants with complicated repair of cardiac malformations.

Blood Gas Analysis↗
PubMed1989

[Electrophysiologic properties of cibenzoline in Wolff-Parkinson-White syndrome and atrioventricular nodal reentry tachycardia].

The electrophysiologic effects of the new class-1 antiarrhythmic drug cibenzoline (1.5 mg/kg within 10 min, followed by an infusion of 0.5 mg for 30 min) were investigated in six patients with atrioventricular (av) nodal reentrant tachycardia and nine patients with atrioventricular tachycardia. Sinus cycle length, sinus node recovery time, effective refractory period (ERP) of the atrium and the ventricle as well as the ERP of the av node were not significantly affected by cibenzoline. Retrograde conduction via the av node was prevented by cibenzoline in 6/15 patients, retrograde ERP was increased in 4/15 patients and in 5/15 patients determination of the retrograde ERP of the AV node was impossible. Intranodal conduction time (AH-interval) and infranodal conduction time (HV-interval) was increased from 96 +/- 27 ms to 117 +/- 40 ms (p less than 0.01) and 36 +/- 12 ms to 62 +/- 12 ms (p less than 0.01), respectively. In four patients with antegrade conduction along the accessory pathway no antegrade conduction was seen after the application of cibenzoline. Retrograde ERP of the accessory pathway was increased in two patients, it was unchanged in three patients, and no retrograde conduction along the accessory pathway was seen in four patients. AV nodal reentrant tachycardia was not inducible, after cibenzoline in 4/6 patients and in 5/9 patients with AV reentrant tachycardia. If tachycardia remained inducible, an increase in tachycardia cycle length from 333 +/- 46 ms to 402 +/- 24 ms was observed (p less than 0.01). In conclusion the electrophysiologic effects of cibenzoline make it a suitable drug for the treatment of av nodal reentrant tachycardia and atrioventricular tachycardia.

Adult↗
PubMed1989

[Para-articular surgical interventions of the hip--a mechanical problem].

From the analysis of a case report the author draws the following conclusions: Combining a perfect reduction with a valgus intertrochanteric osteotomy and a stable fixation ensures almost certainly against non union and probably against a high rate of avascular necrosis in cases of subcapital fractures of the neck of the femur. However, increased compressive stresses must be expected in the joint, above all in obese patients or if the joint surfaces are not congruent. Therefore, unloading is recommended and a secondary varus intertrochanteric osteotomy should be carried out as soon as bony union is achieved. Pauwels' intertrochanteric osteotomy constitutes a sensible treatment of osteoarthritis of the hip and gives amazingly long term good results if the weight bearing surfaces of the joint can be increased and the articular pressure is thus considerably reduced. The cyst in the femoral head results from fractures of cancellous trabeculae subjected to stresses which are beyond of functional adaptation.

Biomechanical Phenomena↗
PubMed1988

[Use of arthrosonography in the diagnosis of Tossy injuries of the shoulder joint].

In a pilot study specificity and sensibility of ultrasonics on Tossy III lesions were tested, and that in 20 cases of guaranteed intact acromioclavicular joints and 22 cases of radiologically diagnosed Tossy III lesions with a following operative control. Additionally in these 22 cases the contralateral acromioclavicular joints were also examined by ultrasonics. All examinations were registered on video tape. With it in a single blind test the exact diagnosis was made in all cases. The diagnosis was based on ultrasonic findings as visible instability, unevenness of the joint line, haematoma formation with ligament stumps. Compared to radiologic diagnostics ultrasonics do not demand cooperative patients or special postures for the examination. A proved accuracy in the diagnosis and the capability of further extension of this technique are of clinical importance. A differentiation of various grades of Tossy lesions is possible.

Acromioclavicular Joint↗