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F Sauger

Publications and source records attributed to F Sauger.

28 records · Page 2Linked to original sources
PubMedDate not supplied

[Plasma determination of homocysteine on CPC Immulite 2000: comparison with determination on IMX Abbott].

Plasma total homocysteine is a parameter frequently included in the biological investigation of arterious or venous thrombotic diseases. Different techniques, chromatographic, enzymatic, and immunochemical, are used in the measurement of homocysteine. Among immunochemical methods, some are conceived to function on multiparametric automates, leading to a greater accessibility of the test for most of the clinical laboratories. In this study, we have evaluated a new immunoassay proposed by the DPC Company for the Immulite 2000 analyzer (chemiluminescence) and compared its performance against the Abbott's immunoassay on IMx (fluorescence polarization). The results obtained show very good general performance of the DPC's technique. Linearity is also excellent. The within run CVs are 9.9, 7.0 and 5.4% and the between run CVs are 8.2, 3.9 and 4.3% respectively for homocysteine levels of 4.2, 13.9 and 27.7 pmol/L. We found a very good correlation between DPC's and Abbott's methods (regression analysis:y=0.948 x + 0.05; r=0.895). The mean of differences between both methods is -0.55 micromol/L. On the whole, the DPC technique appeared in our experience as easily exchangeable, from the analytical point of view, with Abbott's technique.

Blood Chemical Analysis↗
PubMedDate not supplied

[Dysglobulinemic neuropathy. Apropos of IgD myeloma manifested by mononeuritis].

The authors report a case of IgD myeloma of which the initial symptom was a mononeuritis and the biological, immunological and ultrastructural study performed about this case. Then are reviewed the mechanisms, proved or hypothetical, by which are actually explained the event of neuropathies within lympho-plasmocytic disorders.

Amyloidosis↗
PubMedDate not supplied

[Thyroid pathology and lymphoproliferative diseases].

Four cases are reported, of an association between a thyroidal illness (1 hypothyroidism, 3 hyperthyroidism) on one hand, and a lymphocytic proliferation and/or monoclonal gammapathy on the other. The following findings: HLA B8 or DrW3 in 3, antithyroid antibodies at a very high level in 2, and thyroid stimulating immunoglobulin in 2 support the conclusion of thyroidal diseases of auto-immune nature. Simultaneous appearance of both thyroidal and hematologic illness favors the hypothesis of a non coincidental association. A direct thyroidal activity of the monoclonal paraprotein has been found only once among the 4 published and our 2 cases in which it has been studied. A more likely link would be a common physiopathology: a functional deficiency of T suppressor lymphocytes allowing the proliferation of a cellular clone producing an abnormal immunoglobulin, would also allow the development of a thyroidal illness when favored by a genetic predisposition.

Aged↗