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Biomedical subjects

F S Tkach

Publications and source records attributed to F S Tkach.

At least 37 records · Page 2Linked to original sources
PubMedDate not supplied

[Diffuse toxic goiter associated with autoimmune thyroiditis].

A study of 190 patients with diffuse toxic goiter combined with autoimmune thyroiditis has revealed some clinical features: a torpid course and a solid-elastic consistency of the thyroid. In 37.4% of the cases autoimmune thyroiditis was combined with a severe form of thyrotoxicosis. The combined form of diffuse toxic goiter correlated with a greater frequency of the detection of thyroid autoantibodies to thyroglobulin and microsomal antigen (in 83 and 78.3% of the patients respectively) as compared to the common form of diffuse toxic goiter (in 47.3 and 48.1%). A study of the hormonal thyroid status of 43 patients with diffuse toxic goiter combined with autoimmune thyroiditis showed that T3, T4 and TTH levels in patients with the presence of autoantibodies to thyroid antigens did not differ from the levels of these hormones in the common form of diffuse toxic goiter, and in the group of the patients with the absence of autoantibodies there was a tendency to the development of T3-toxicosis. The absence of pathognomic symptoms in combined forms of diffuse toxic goiter makes their preoperative diagnosis difficult. Interrelationship of the hormonal thyroid status and humoral antithyroid immunity was noted.

Adolescent↗
PubMedDate not supplied

[Glucocorticoid and androgenic functions of the adrenal cortex and the state of the sympathetic-adrenal system in thyrotoxicosis with primary organic disease of the central nervous system].

In patients with thyrotoxicosis combined with primary affection of the central nervous system (CNS)-encephalitis, diencephalitis-there was revealed, like in common thyrotoxicosis, an increased production by the adrenal cortex of hydrocortisone, its intensified transformation and inactivation, reduced production of 17-ketosteroid chiefly due to the fall of dehydroepiandrosterone content, an increased urinary excretion of adrenaline and a decreased-of noradrenaline. The use of functional test with the ACTH administration demonstrated organic affection of the CNS to sharply aggravate the weakening and even the exhaustion of the functional reserves of the glomerular and the reticular zones of the adrenal cortex developing during thyrotoxicosis, and also the reserve possibilities of the sympathico-adrenal system. Direction of the changes in the 24-hour excretion of 17-OCS and corticosteriods was the same in the majority of cases. The latter can point to the presence of functional association between the hypothalamus-hypophysis-adrenal cortex systems and adrenergic regulation in these patients.

17-Hydroxycorticosteroids↗
PubMedDate not supplied

[Characteristics of microcirculation in patients with diabetic angiopathies].

The radionuclide technique was used to study regional microcirculation in 139 patients with diabetic angiopathies of the lower limbs. All the examined demonstrated impairment of the muscular bloodflow, that increased depending on the disease stage and diabetes mellitus standing. No differences were recorded in the degree of bloodflow impairment in the muscles of patients treated with sulfanilurea drugs and insulin. Comparison of the degree of changes in the muscular bloodflow in diabetic angiopathies of the lower limbs and atherosclerosis obliterans of lower limb vessels in subjects without diabetes mellitus demonstrated that microcirculation in the former group patients was affected to a greater measure. It is desirable that the complex of therapeutic measures should include drugs that improve microcirculation at the early stages of the management of patients with diabetic angiopathies of the lower limbs.

Adult↗