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Biomedical subjects

F S Tennant

Publications and source records attributed to F S Tennant.

At least 91 records · Page 5Linked to original sources
PubMed1969

"Pseudopurpura".

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Adult↗
PubMedDate not supplied

Serum propoxyphene concentrations in a cohort of opiate addicts on long-term propoxyphene maintenance therapy. Evidence for drug tolerance in humans.

Propoxyphene, norpropoxyphene, and cyclic dinorpropoxyphene concentrations in the sera of eight opiate addicts were measured by gas chromatography. The addicts were enrolled in a propoxyphene maintenance program and had received 800-1600 mg of propoxyphene napsylate daily for 13-50 months. Serum propoxyphene and norpropoxyphene ranged from 127 to 1070 ng/mL and 814 to 2638 ng/mL, respectively, and their ratio ranged from 0.1 to 0.4. A roughly linear dose-to-serum-concentration relationship was found for serum propoxyphene and norpropoxyphene in the cohort. Cyclic dinorpropoxyphene was detected in three of the subjects' sera. Because tolerance to propoxyphene occurs, knowledge of prior drug exposure is necessary to determine whether an elevated propoxyphene or norpropoxyphene concentration is toxic to patients or decedents with apparent propoxyphene overdose. Serum norpropoxyphene concentration exceeds that of propoxyphene following chronic propoxyphene use. Measurable cyclic dinorpropoxyphene implies chronic propoxyphene use but its absence does not exclude chronic use.

Adult↗
PubMedDate not supplied

Benefits of recurrent, outpatient heroin detoxification.

Recurrent heroin detoxification, or the "revolving-door" process, is the treatment of choice for many addicts. Forty-five heroin addicts were detoxified 145 times (mean = 3.2 per patient) on an outpatient basis over a 3-year period and showed significant improvement in arrest and hospitalization rates but not employment or intact marriages. Another group of 74 patients who had detoxified two or more times were compared to a similar group of 61 methadone maintenance (mean maintenance time = 17.9 weeks) patients, and no significant difference was found in a variety of health, employment, and social indicators. These findings indicate that recurrent, outpatient heroin detoxification has some therapeutic benefits and provides an explanation for patient popularity.

Adult↗