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Biomedical subjects

F S Tennant

Publications and source records attributed to F S Tennant.

At least 73 records · Page 4Linked to original sources
PubMed1978

Coordination of institution and parole services: an innovation within California's Civil Addict Program.

Parole outcome was measured 1 year after release of 397 narcotic addicts processed by an experimental program in which both institution and parole services were administered together. Conparison of outcome of this group to the outcome of 361 traditionally processed addicts revealed a positive effect on parole outcome of violators (those with prior parole experience) compared to new commitments (p less than .05). This was particularly true for the community parole unit which made most use of community resources (p less than .05). Community adjustment of some narcotic addicts may be increased by administrative interdependence and by optimal use of other community resources. The future for such programs seems brightest at the local level of government.

Adult↗
PubMed1977

Use of difenoximide (SC-26100) for narcotic detoxification: a preliminary tolerance and efficacy study.

Difenoximide (SC-26100) is closely related to the antidiarrheal agent, diphenoxylate, which is a chemical congener of meperidine. It has been shown to have a greater ability than methadone to suppress opiate withdrawal in addicted mice, and it has produced less physical dependence than morphine and methadone in laboratory animals. In this study difenoximide was administered to nine active heroin addicts. A dose of 4 mg administered 4 times per day for 3 days effectively suppressed opiate withdrawal, while a dose of 8 mg produced symptoms resembling those of narcotic excess in subjects who had recently self-administered heroin. No side effect were observed at the therapeutic dosage level, and the drug was well accepted by subjects. Difenoximide was shown to be a potentially useful narcotic treatment agent in this impatient study.

Adolescent↗
PubMed1976

Clinical trial in post-addicts with oxilorphan (levo-BC-2605): a new narcotic antagonist.

Oxilorphan (levo-BC-2605) is a new, long-acting, narcotic antagonist that has agonist properties. Twenty-one (21) heroin addicts in Los Angeles were detoxified and given at least one oral dose of oxilorphan. Only three (14.3%) patients took daily doses for 14 days, which was the maximal time allowed for oxilorphan administration in this study. The remainder discontinued oxilorphan because of subjective side effects or for unknown reasons. Side effects most responsible for dropouts were dysphoria, insomnia, weakness, hallucinations, nausea, drowsiness and anorexia. Oxilorphan provided 24-hour protection with a single, oral dose, but subjective side effects encountered during inductiolinical trials with oxilorphan should be attempted with other addict populations to fully determine its potential therapeutic value.

Adult↗
PubMed1976

Outpatient heroin detoxification with acupuncture and staplepuncture.

Eighteen heroin addicts were treated as outpatients with acupuncture, electrical stimulation and staplepuncture. Results of treatment were compared with results in two similar groups of 18 persons in whom detoxification was carried out using methadone and propoxyphene napsylate. Withdrawal symptoms were relieved for about two hours in most of the patients after a treatment episode of acupuncture and electrical stimulation. Staplepuncture, which is the manipulation by hand of a surgical staple implanted in the concha of the ear, was reported to relieve withdrawal symptoms at least partially in approximately 40 percent of subjects. In only one person of the group treated with acupuncture or staplepuncture was complete detoxification achieved, compared with 13 and 10 persons, respectively, in the methadone and propoxyphene napsylate groups (p<.001). Use of acupuncture and staplepuncture in outpatient clinics may be limited unless techniques can be found that will relieve withdrawal symptoms for a longer period than that observed in this study.

Acupuncture Therapy↗
PubMed1975

Heroin detoxification. A comparison of propoxyphene and methadone.

Propoxyphene napsylate and methadone hydrochloride were each administered under double-blind conditions to 36 outpatients for 21-day heroin detoxification. The initial dosage was 24 mg/day for methadone hydrochloride and 800 mg/day for propoxyphene napsylate. At these dosages, methadone more effectively suppressed the opiate-withdrawal syndrome, and patients remained in treatment longer in the methadone group (P greater than .05). In regard to heroin abstinence, however, results were not statistically significant in either group, as indicated by the number of patients whose urine was positive for morphine on admission and became negative during treatment, and the number who had morphine-negative urine at the conclusion of 21-day treatment. A one-month follow-up of patients showed that more patients given methadone had entered long-term medical maintenance while more patients given propoxyphene were heroin-abstinent. This study indicates that 21-day heroin detoxification, regardless of chemotherapeutic agent, yields a low rate of heroin abstinence.

Adolescent↗
PubMed1975

Some childhood antecedents of drug and alcohol abuse.

Unsatisfactory intrafamilial relationships and child-rearing practices have frequently been implicated as prime determinants of personalities that are susceptible to drug and alcohol abuse. Five thousand forty-four US Army soldiers were surveyed by anonymous questionnaires. The reported occurrence of a variety of activities, events and behaviors in childhood among drug and alcohol abusers were compared to non users. Childhood antecedents that were associated with non-use of illegal drugs and which showed as much as a 20% difference in reported occurrence between abusers and non-users of illegal drugs were: spanking, church attendance, first alcoholic drink after 15 years, and perceived "happy" parental marriage. These associations were found uithin white and non-white groups and in subjects with divorced or separated parents. There was no antecedent that showed as much as a 20% difference in reported occurrence between alcohol abusers and non-users.

Adolescent↗