Search PubMed⌕ Search

Biomedical subjects

F S Larsen

Publications and source records attributed to F S Larsen.

103 records · Page 6Linked to original sources
PubMed1979

Nickel dermatitis provoked by buttons in blue jeans.

A total of 79 nickel-sensitive patients (65 women, 14 men) were examined with regard to a present or past eczema corresponding to contact with metallic buttons in blue jeans; 63% of the women and 64% of the men had or had had eczema of this kind. Among 40% of the women below 30 years this was the primary site of manifestation. The seriousness of this sensitivity is illustrated by the fact that two-thirds of the nickel sensitive patients with button dermatitis had or had had eczema of the hands. The conclusion is that blue jean buttons should be made of a material which does not contain nickel, for instance zinc alloys which are presently used for some metallic buttons, or they should be designed in such a way that the button does not directly contact the skin.

Adolescent↗
PubMed1979

Comedo formation following cobalt irradiation.

After cobalt-60 therapy 3 patients developed open and closed comedones in the face corresponding to the treatment fields. Biopsies showed extensive dermal elastotic material. It is suggested that the elastotic fibres may contribute to a change in the supporting function of the dermis and a secondary sebum retention and comedo formation.

Acne Vulgaris↗
PubMed1979

Multiple glomus tumours: a report of a family in Denmark.

In a family affected by multiple glomus tumours, one of the members had approximately 500 tumours spread over the entire skin. The histopathological similarity to cavernous haemangioma is emphasized. We consider that multiple glomus tumour is a more common skin disease than is assumed today.

Adult↗
PubMed1979

Clinical trial of a new chromone compound for systemic treatment of atopic dermatitis.

In a double-blind group comparative study, 14 adults with atopic dermatitis were treated systemically for 6 weeks with a new anti-allergic chromone compound (FPL 57787) 6 mg four times a day. A similar group of 13 adults was given placebo. Both groups improved during the trial in all the clinical assessments without significant differences, but there was a tendency to a decreased use of local treatment (hydrocortisone butyrate) in the active group during the trial. There were no drug-related complaints, but one patient in the active group had transiently elevated liver enzyme levels. Further investigations are warranted.

Administration, Topical↗
PubMed1978

Atopic dermatitis and congenital deafness.

In a family with perceptive, non-progressive hearing loss several of the members suffered from atopic dermatitis. The proband had a severe atopic dermatitis and an extremely high IgE value. Some of the family members suffered from atopic dermatitis, others from deafness, and some from both diseases. The co-existence of these two disorders has been previously described in two families. Atopic dermatitis and perceptive, non-progressive congenital deafness might be genetically associated.

Adolescent↗
PubMed1978

Inhibitory and stimulatory effect of spleen cells from tumour bearing animals on the growth of syngeneic tumour cells.

When spleen cells from C3H mice inoculated with a primary spontaneously arisen C3H mammary carcinoma were added to tumour target cells of the same type in vitro, both an inhibitory and a stimulatory effect on target cell growth were seen, when compared with the effect of adding normal syngeneic spleen cells. The inhibitory effect was seen regularly when high concentrations of spleen cells were added, while there was a stimulatory effect when low concentrations were added to the tumour target cells. When transferring spleen cells from tumour bearing mice together with a tumour inoculum to groups of normal syngeneic recipients, the resultant tumour growth was enhanced, as compared with recipients given tumour plus normal spleen cells and those given tumour cells only. It was found that the spleen cells which caused the greastest enhancement in vitro caused the greatest inhibition in vitro. This relationship could be explained by assuming the occurrence in spleens of tumour bearers of a population of reactive cells which when added in high concentrations to tumour target cells in vitro cause inhibition, while they cause stimulation of tumour growth in vivo because of being transferred to recipients in relatively low concentrations.

Animals↗
PubMedDate not supplied

Circulating levels of neuropeptides (CGRP, VIP, NPY) in patients with fulminant hepatic failure.

The present study investigated the circulating levels and cerebral fluxes of calcitonin gene-related peptide (CGRP), vasoactive intestinal peptide (VIP), and neuropeptide Y (NPY) and their relation to cerebral blood flow (CBF) during normoventilation and hyperventilation in patients with fulminant hepatic failure (FHF). Sixteen patients with FHF were studied and compared to six patients with cirrhosis of the liver. CBF was measured by the (133)Xe wash-out technique. Blood samples were obtained simultaneously from the artery and internal jugular bulb. Concentrations of CGRP and VIP were higher in FHF than in cirrhosis, 87 (55-218) vs. 29 (21-42) pmol/L, and 11 (6-29) vs. 5 (3-9)pmol/L, respectively. NPY was normal, none of the measures were related to CBF, and there was no detectable net brain fluxes. Hyperventilation did not alter any of the measures. CGRP and VIP in FHF seem to reflect hemodynamic changes in the systemic rather than in the cerebral circulation.

Adult↗
PubMedDate not supplied

Fairness in the match.

Explore the source record for details and available documents.

Family Practice↗