The pharmacokinetics of meropenem were determined in 9 healthy volunteers after the administration of 1 g dose by injection over 2, 3 or 5 min. Peak plasma concentrations were not significantly different across the three rates of administration and, due to the finite time required for complete mixing of the blood in the central compartment, did not always occur at the end of the injection. Overall exposure to meropenem was unchanged by the more rapid rates of administration. Plasma clearance, terminal half-life and volume of distribution were virtually unchanged. Within 10 min after the start of the injection, the plasma concentrations from all three injections were very similar indicating that dosing over 2, 3 or 5 min would result in similar antimicrobial cover and, therefore, comparable efficacy. Comparison of the data derived from the three injections indicated that rapid administration of meropenem did not appreciably alter its disposition pharmacokinetics. Tolerability of meropenem was unchanged with the more rapid administration rate.

Adolescent↗

PubMedDate not supplied

Childhood drowning in New South Wales 1990-1995: a population-based study.

OBJECTIVE: To review the circumstances of children drowning in New South Wales (NSW), 1990-1995, and to analyse trends. DESIGN: The NSW Paediatric Trauma Death Review Data Unit received coronial notification of childhood drowning deaths. Age-specific annual drowning rates per 100,000 population were calculated. SUBJECTS: Children aged 0-14 years who died of drowning. RESULTS: 132 children drowned (96[73%] aged 0-4 years). There was was an overall decrease in incidence of drowning, from 2.0 to 1.5 per 100,000 population, and a decline in domestic pool drownings (from a peak of 15 in 1992 to five in 1995), and in drownings in waterways (from nine to six over the six-year period). However, drownings in baths and dams did not decrease. In general, boys were at higher risk than girls. CONCLUSIONS: Analysis of the drowning incidents indicates that, despite the decreases documented, we should not be complacent, and preventive programs are still warranted. All pools and dams should have well maintained fences between the body of water and the house. All infants aged under three and all epileptic children should be supervised in the bath by an adult. Children should be taught to swim, warned of the dangers of rivers and surf, and adequately supervised.

Adolescent↗

PubMedDate not supplied