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Biomedical subjects

F Rosner

Publications and source records attributed to F Rosner.

At least 289 records · Page 16Linked to original sources
PubMed1978

Two dimensional view of combination chemotherapy in vitro.

A newly developed micromethod to evaluate the cytotoxic effects of drugs on rapidly growing lymphoid cell lines is described, which permits evaluation of more than one variable. This technique allows a checkerboard titration of two drugs to determine the optimum concentration of each needed for the augmentation of the other's cell-killing activity. Such studies have shown that the minimum concentration of vincristine capable of killing a human lymphoid cell population is 5.6 ng/ml. The addition of prednisolone at a concentration of 460 ng/ml reduces the minimum lethal concentration of vincristine to 1.6 ng/ml. When prednisolone is added to vincristine at concentrations of 2.8 mu/ml (a level readily achieved in the serum in vivo) concentrations of vincristine as low as 200 pg/ml are clearly cytotoxic. Similar potentiation of cytotoxicity following the addition of prednisolone has been demonstrated for cytosine arabinoside, but not for daunorubicin and only slightly for methotrexate. The micromethod for the study of optimal doses to be used in drug combinations is simple and gives healthy reproducible results. It should be of considerable utility to anyone interested in screening a wide variety of drug combinations for augmentation or synergistic effects.

Cell Line↗
PubMed1978

Potentiation of vincristine cytotoxicity by hormones: corticosteroids, androgens, estrogens and progestins.

Using an in vitro system to evaluate the simultaneous use of two drugs, we previously have confirmed the synergism of vincristine and prednisolone cytotoxicity against lymphoid cells. Experiments were now carried out to determine whether other steroid hormones can be substituted for prednisolone. Partial or complete potentiation of vincristine cytotoxicity comparable to that achieved by the addition of prednisolone was observed when the latter drug was replaced by a variety of mineralocorticoids (aldosterone, desoxycorticosterone and fludrocortisone), glucocorticoids (hydrocortisone, dexamethasone), androgens (testosterone, methyltestosterone, androsterone, dehydroepiandrosterone, etiocholanolone), estrogens (estrone, 17-beta estradiol) and progestins (progesterone, pregnanediol). No potentiation of cytotoxicity was observed when nonsteroidal hormones (thyroxin, ACTH) were added to vincristine. It is concluded that a wide variety of compounds with the basic perhydrocyclopentanophenanthrene nucleus of the steroid molecule are capable of enhancing the cytotoxicity achieved with vincristine.

Adrenal Cortex Hormones↗
PubMed1978

Malignant lymphoma associated with marked eosinophilia.

A 60-year-old black man with poorly differentiated lymphocytic lymphoma presented with generalized lymphadenopathy and marked eosinophilia. Extensive evaluation of the eosinophils revealed them to be normal morphologically and functionally. The patient responded to corticosteroid therapy with resolution of the lymphadenopathy and reversion of the peripheral blood counts to normal limits. Recurrence of the original clinical picture within months prompted institution of systemic chemotherapy. Response was transient, and the patient expired after an unremitting downhill course. Recent advances in our knowledge of mechanisms of eosinophilia and eosinophil function are reviewed. The relationship of lymphoma to eosinophilia is discussed.

Eosinophilia↗
PubMed1978

A prototype 'fifth pathway' program for Americans studying abroad.

A problem of American citizens studying medicine abroad is reviewed along with that of foreign medical graduates who are foreign nationals, and a prototype "fifth pathway" program is briefly described. The objective of the program is the return of qualified American students who study medicine abroad to the mainstream of contemporary American medical education and the preparation of these students for further graduate education and the fulfillment of responsible roles in the delivery of health care.

Clinical Competence↗
PubMed1978

The effectiveness of sickle cell counseling.

Patients received information about hemoglobinopathies before blood testing. Those in whom sickle cell trait was confirmed were counseled. Then, this group responded to a questionnaire to evaluate understanding and retention of information about sickle cell disease. Ninety percent correct responses were obtained on general information. However, only 70 percent correct responses were received on questions about genetics. Modifications of techniques of sickle cell counseling are suggested by these results.

Adolescent↗
PubMed1978

The effectiveness of sickle cell education in New York City public elementary schools.

The present study attempts to ascertain the effectiveness of the health education component of the Queens Hospital Center Sickle Cell Education & Screening Program. The study is limited to children in grades four through six in the New York City public school system. Such elementary school students, representing a large segment of the population, are easily accessible and can be effectively educated about sickle cell disease. The findings indicate that professional sickle cell educators can successfully teach young children about the disease and can do so more effectively than the average schoolteacher.

Anemia, Sickle Cell↗