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Biomedical subjects

F Rosner

Publications and source records attributed to F Rosner.

At least 271 records · Page 15Linked to original sources
PubMed1979

Acute myeloblastic leukemia following treatment for non-hematopoietic cancers: report of 19 cases and review of the literature.

Nineteen patients are reported who developed acute myeloblastic leukemia following treatment for a variety of solid tumors, including seminoma (four cases), melanoma (one case), and cancer of the ovary (six cases), colon or rectum (three cases), bladder (two cases), cervix, endometrium, and larynx (one case each). There were nine men and ten women, with a median age of 49.8 years (range 29 to 75). The mean interval between the diagnosis of solid tumors and acute leukemia is 5.8 years. In two patients the two diseases occurred simultaneously or within six months of each other. One patient was treated only surgically. Eight patients were treated with radiotherapy, five with chemotherapy, and five received both chemotherapy and radiotherapy. Pancytopenia was commonly noted prior to the onset of leukemia with chromosomal abnormalities observed in four cases in which a karyotype was performed. Three patients achieved complete hematological remission following antileukemic therapy. One hundred and six additional patients with non-hematopoietic neoplasms and acute leukemia are reviewed. Although acute leukemia may occur in a higher than expected frequency in patients with solid tumors because of a possible increased risk of a second neoplasm, it seems more likely that the acute leukemia is related to the radiotherapy and/or chemotherapy administered to treat the first neoplasm.

Adult↗
PubMed1979

Naked megakaryocyte nuclei revisited.

Bone marrow smears from 35 patients with various neoplasms and from 32 control patients were examined for the presence and percentage of naked megakaryocyte nuclei (NMN). The percentages of NMN in the two groups did not significantly differ. We conclude that the enumeration of NMN is of no value as a diagnostic test of malignancy.

Bone Marrow Examination↗
PubMed1979

An unusual case of T-cell lymphoproliferative disorder.

A 54-year-old woman with epigastric pain had leukocytosis of 73,000/microliter consisting mainly of atypical lymphoid cells with convoluted and cleaved nuclei resembling Sézary cells; the bone marrow aspirate was nondiagnostic. Skin biopsy was unremarkable. The patient also had hypercalcemia and hemolysis with a positive direct Coombs' test, both of short duration. The arterial oxygen tension was decreased, but there was no demonstrable lung pathology. The patient subsequently developed rapidly enlarging lymphadenopathy. Lymph node biopsy was interpreted as "undifferentiated pleomorphic lymphoma." Immunologic functional studies revealed that the majority of the peripheral blood atypical lymphoid cells from involved lymph nodes formed rosettes with sheep erythrocytes. The lymphadenopathy regressed transiently after the administration of chemotherapy and the white blood cell count decreased from a maximum of 385,000/microliter to 3,500/microleter, at which point the arterial oxygen tension returned to normal. The unusual features of this patient are discussed in light of the known characteristics of the various types of T-cell lymphorpoliferative disorders.

Female↗
PubMed1979

The Biblical and Talmudic secret for choosing one's baby's sex.

The Biblical verse "If a woman emits semen and bears a manchild" (Leviticus 12:2) is interpreted by the Talmudic Sages and more recent Jewish sources to mean that if a woman emits her "semen" first, she will bear a male child but if the man emits his semen first, she will bear a female child. The Sages of the Talmud thus claimed to have known the secret of determining one's baby's sex. However, whether "emitting one's semen first" refers to orgasm, ovulation, both or neither, is not clear.

Bible↗
PubMed1979

Infantile type of chronic myelogenous leukemia in a 16-year-old boy.

Three varieties of chronic myelogenous leukemia (CML) occur in childhood familial, infantile, and adult (or ""juvenile'') types, each with distinct clinical and laboratory features. We report an unuusual case of CML with the characteristic features of the infantile type in a 16-year-old boy.

Adolescent↗
PubMed1979

Acute leukemia and immunosupressive drug use: a review of patients undergoing immunosuppressive therapy for non-neoplastic diseases.

We have reviewed 61 reported cases of acute leukemia developing in patients who had previously received immunosuppressive agents for non-neoplastic disorders. In three patients the diagnosis of acute leukemia was made less than six months after the first exposure to immunosuppressive drugs and was, therefore, considered coincidental. Among the remaining 58 patients, most diagnoses were of myeloblastic or myelomonocytic leukemia. The underlying diagnoses in most of the 58 patients were rheumatoid arthritis or renal disease or renal transplant. Thirty patients had received alkylating agents exclusively, 10 had received antimetabolites only, while the remaining 18 patients had received multiple therapeutic modalities including antimetabolites, alkylating agents, and/or radiation. Most patients had also received large amounts of corticosteroids. Although we do not have the overall denominator of population at risk, the relatively high proportion of patients who had received alkylating agents before developing acute leukemia doses suggest a causal relationship, and one might, therefore, hesitate before using such drugs in non-life-threatening diseases.

Acute Disease↗
PubMed1979

Experience of children with sickle cell anemia in a regular summer camp.

The Sickle Cell Program of the Queens Hospital Center Affiliation of the Long Island Jewish-Hillside Medical Center arranged for a group of children from the hospital Sickle Cell Clinic to spend one week during the summer of 1978 in a sleepaway camp for healthy children. This paper analyzës the results of the experience.

Anemia, Sickle Cell↗
PubMed1978

Oral contraceptives and platelet aggregation.

There are conflicting data in the literature concerning the effects of oral contraceptives on platelet aggregation. We studied 26 healthy women who used oral contraceptives for at least three months. The control group consisted of 25 healthy women of childbearing age, who were receiving no medications. No differences in platelet aggregation in response to adenosine diphosphate, epinephrine, and collagen were found between the two groups.

Adenosine Diphosphate↗
PubMed1978

Sperm procurement and analysis in Jewish law.

Whether, and how, a husband whose marriage has proved barren may procure a sample of his semen for a fertility test is a question that has often been discussed in rabbinic writings. It is permissible according to most rabbis to obtain sperm from the husband both for analysis and for insemination, but a difference of opinion exists as to the method to be used in the procurement of it. Masturbation should be avoided if at all possible and coitus interruptus or the use of a condom seem to be the preferred methods. Since many important legal and moral considerations, which cannot be enunciated in the presentation of general principles, may weigh heavily upon the verdict in any given situation, it seems advisable to submit each individual case to rabbinic judgment, which, in turn, will be based upon expert medical advice and other prevailing circumstances.

Female↗