Search PubMed⌕ Search

Biomedical subjects

F Rasmussen

Publications and source records attributed to F Rasmussen.

At least 109 records · Page 6Linked to original sources
PubMed1990

Long-term treatment with antiandrogens.

Since the first report in 1966 by Scott and Schirmer on the clinical use of antiandrogens in patients with prostatic cancer, several studies have been published. Most of these deal with short-term treatment and include only a limited number of patients. Steroid antiandrogens have demonstrable progestational and antigonadotrophic effects, whereas the non-steroid "pure" antiandrogens mainly act peripherally on androgen-dependent accessory genital organs and thus preserve libido and sexual potency in most patients. Short-term treatment with antiandrogens have exerted responses similar to those achieved with conventional endocrine therapy. Because of relatively fewer side effects of these drugs, there is an increasing interest in assessment of the long-term effect, and some studies have been initiated.

Androgen Antagonists↗
PubMed1990

Intravenous urography with a new non-ionic contrast media in a clinical phase III study: iopentol vs iohexol.

The safety and diagnostic efficacy of iopentol 300 mg I/ml were compared with iohexol 300 mg I/ml in 300 patients submitted for urography. The study was carried out as a double-blind, randomised parallel study where 149 patients received iopentol and 150 patients iohexol. There were no significant differences between the patients receiving the two contrast media with regard to demographic parameters, rate of injection or total dose of injected contrast media. No changes in blood pressure and no clinically important changes in heart rate were detected in the two groups. No serious adverse effects occurred. Seven patients (5%) in the iohexol and 12 patients (8%) in the iopentol group experienced adverse effects other than a sensation of warmth. Fourteen iohexol patients (9%) and 18 iopentol patients (12%) experienced warmth related to the contrast injection. Excellent films were obtained in most patients and no difference in diagnostic quality between iopentol and iohexol was observed.

Adult↗
PubMed1990

Granulocyte chemotaxis. Influence of radiographic contrast media on the chemoattractive properties of serum.

One of the important functions of granulocytes is the ability to respond to a chemoattractive signal by migration. The influence of radiographic contrast media (CM) on the chemoattractive properties of serum was investigated by under agarose technique for chemotaxis. No chemotactic response was seen when serum was incubated with different concentrations of CM after heat inactivation. The CM did not generate the heat stable complement split product C5a-desarg which would have resulted in a chemotactic response. Without heat inactivation all complement available in the serum was activated by the agarose in the chemotaxis assay. Low concentrations of iohexol and iodixanol brought about an increased chemotactic response relative to a reference with saline instead of CM. This may be due to activation of heat labile chemoattractants from other sources than the complement cascade. At high concentrations of all five investigated CM, a decreased number of granulocytes migrated over a shorter distance when compared with the reference, and this may be due to interactions between the CM and chemoattractants or their precursors.

Chemotaxis↗
PubMed1989

Ultrasonically guided 125iodine seed implantation with external radiation in management of localized prostatic carcinoma.

Thirty-three patients with localized prostatic carcinoma (16 poorly differentiated) were treated with transperineal 125Iodine seed implantation (160 Gy) guided by transrectal ultrasonography and subsequent external beam irradiation (47.4 Gy). The observation time was six to sixty-eight months with a median follow-up of thirty-five months. Median change in prostatic volume was a reduction of 35 percent. Re-biopsy or transurethral resection of the prostate was performed in 25 patients after one to two years, revealing still malignant histology in 12 (48%). Development of distant metastases occurred in 14 patients (44%), and 8 have died of prostatic cancer. Fourteen patients suffered from late complications of which surgical intervention was indicated in 3 cases.

Aged↗
PubMed1989

Mothers' benefit of a self-care booklet and a self-care educational session at child health centres.

Mothers' benefit of a mass-distributed self-care booklet and a self-care educational session about young children's minor illnesses were investigated. The following questions were studied: (1) Do mothers of infants read and benefit from a self-care booklet? (2) Is the mothers' knowledge about self-care improved more if the booklet is supplemented by a self-care educational session? 265 (92%) of 288 randomly sampled Swedish mothers whose first child was 6-12 months of age were interviewed regarding their knowledge about self-care. Shortly thereafter a self-care booklet was mailed to all households in Uppsala county and 6.5 months later a new group of 572 mothers was randomly sampled. Among the 572 mothers, 332 (58%) were randomized to a self-care session organized at child health centres and 240 (42%) were not invited to a session. Of the 572 mothers, 530 (93%) were later interviewed about the booklet, the session and their knowledge about self-care. 69% participated among the mothers randomized to the session. Among these mothers, 99% recalled the booklet and 96% had read the child care section. Among the mothers not invited to the session, 68% recalled the booklet and 60% had read the child care section. The mothers who had read the child care section would follow the recommendations about when to seek (and not to seek) medical care significantly better than those who had not read it (P less than 0.003).(ABSTRACT TRUNCATED AT 250 WORDS)

Child Health Services↗
PubMed1989

Disability in children with myelomeningocele. A Nordic study.

This study was carried out to evaluate the medical impairments and disability among 527 children with myelomeningocele living in four Nordic countries. The information was extracted form questionnaires and data based on case records. The level of intellectual functioning was fairly high with 76% within normal range (IQ greater than 90). Shunt operations were performed in 68% of the children and 1/3 had had four or more shunt revisions. Twenty-three per cent walked without support. Bladder incontinence was found in 60% of the children whereas 4% were entirely continent. Intermittent catheterisation was used in 36% with higher frequency among girls (48%) than boys (24%). We found a higher incidence of bacteriuria among those who used catheterisation than among those who used manual compression. Bowel control was experienced by 112 (21%) of the children. The overall disability is classified according to Lorbber's 5-graded handicap scale and Lagergren's 3-graded scale. According to Lagergren's scale, 70% suffered form severe overall disability.

Adolescent↗
PubMed1989

Life table methods applied to use of medical care and of prescription drugs in early childhood.

Life table methods were applied to analyses of longitudinal data on the use of medical care during the first 5 years of life among all 1701 children born in a Swedish semirural municipality. Cumulative proportions of the children who had used particular types of medical care or prescription drugs at least once by certain ages were estimated. By the fifth birthday, 98% had made at least one visit to any physician and 82% at least one visit to a paediatrician. By the fifth birthday at least one prescription for antibiotics had been purchased at a pharmacy by 82%; and 33% had been admitted to inpatient hospital care at least once (excluding immediate postnatal care). Acute conditions and more chronic diseases were also studied using these methods. At least one visit to a physician at a primary health care centre had been made for acute otitis media in 65% of 5 year olds and for atopic dermatitis in 8%.

Child Health Services↗
PubMed1989

Treatment of advanced prostate cancer.

In the management of advanced prostatic cancer, available treatments are reviewed. Preliminary results of several studies show a better response to complete androgen blockade than to conventional treatments. Prostatic tumour consists of androgen-dependent and -independent cells, and the continued growth of the latter, following androgen ablation, results in relapse.

Humans↗
PubMed1988

Ofloxacin compared with ciprofloxacin in the treatment of complicated lower urinary tract infections.

In a double-blind, double-dummy study 61 patients with structural or functional abnormalities of the urinary tract and verified infection were treated for 7 days with ofloxacin 100 mg bd or ciprofloxacin 250 mg bd by mouth. Of 62 isolated strains none was resistant to ofloxacin or ciprofloxacin in vitro. Nineteen patients (63%) in both groups were free from infection ten days after therapy. Clinical resolution of symptoms occurred in 83% in the ofloxacin group and 68% in the ciprofloxacin group. Adverse reactions were reported in four patients (6.5%), two with skin rash, one with gastrointestinal disturbance and one with influenza-like symptoms. This study demonstrates that ofloxacin and ciprofloxacin are effective in the treatment of complicated lower urinary tract infection.

Ciprofloxacin↗
PubMed1988

The effect of radiographic contrast media on the chemotaxis of granulocytes.

The direct in vitro effect of radiographic contrast media (RCM) on granulocyte locomotion was assayed using an under agarose technique. All RCM tested inhibited the chemotactic response to N-fmlp, a synthetic chemotactic N-formylated tripeptide, which is an analogue of natural bacterial products. The inhibition was most pronounced for diatrizoate, the most hyperosmolar of the RCM, but hyperosmolality per se was not the only inhibitive factor, since 0.5 M NaCl, which has an osmolality comparable to the RCM used, did not inhibit chemotaxis significantly. Furthermore, the inhibition was not caused by a nonspecific sticky effect of RCM on granulocytes, since spontaneous migration was normal. We propose that the inhibition might be caused by competitive binding of RCM to the N-fmlp receptor sited on leukocytes because the third amino acid in N-fmlp is phenylalanine, which, like the RCM, contains a benzene ring.

Chemotaxis↗
PubMed1988

Use of antibiotics and prescription drugs in general during the first 9 years of life in a Swedish community.

The use of antibiotic drugs and of prescription drugs in general during the first 9 years of life was studied among all 1701 children born in a Swedish municipality. Cumulative proportions of children who had received one or more prescriptions for any type of drug and for different groups of antibiotic drugs were estimated by life-table methods. The effects on drug use of the gender and the birth order of the child along with the age, citizenship and marital status of the mother were analysed by Cox's proportional hazards regression model. Half of the children had received at least one prescription for any drug after 0.6 years and at least one prescription for any antibiotic drug after 1.8 years. Higher proportions of children with prescriptions for all drugs and for all antibiotic drugs were found among males than females, among those with older siblings compared with first-borns and among children of younger mothers compared with those of older mothers.

Anti-Bacterial Agents↗
PubMed1988

Flutamide versus stilboestrol in the management of advanced prostatic cancer. A controlled prospective study.

In a prospective randomised study the effect of flutamide 750 mg daily was compared with that of stilboestrol 3 mg daily in the treatment of 40 previously untreated patients with advanced prostatic cancer. There was a good subjective response to both treatments. After 12 months, a response was demonstrated in 13 of 20 patients treated with flutamide and 8 of 20 patients treated with stilboestrol. The difference was not statistically significant. Treatment with stilboestrol caused more frequent, and more severe, side effects than flutamide.

Aged↗
PubMed1988

Good prognosis after calcaneal fracture in childhood.

Fifteen children who sustained a displaced intraarticular calcaneal fracture, treated closed, were reexamined after 12 (1-29) years. All were satisfactory, although slight inconvenience was encountered as a result of the fracture. Immobilization and nonweight bearing from 4 to 6 weeks seem sufficient to treat a calcaneal fracture in children.

Adolescent↗