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Biomedical subjects

F Rasmussen

Publications and source records attributed to F Rasmussen.

At least 199 records · Page 11Linked to original sources
PubMed1975

Mammary excretion of digoxin in goats.

The binding of digoxin to proteins in plasma and milk was about 20% lower after the addition of the drug to plasma and milk (in vitro) than its binding in plasma and milk from animals administered digoxin parenterally. The mammary excretion of digoxin was examined in the experiments on goats. The concentration of non-protein-bound digoxin in milk was slightly lower than the concentration of non-protein-bound in plasma suggesting a passive diffusion. The amount of digoxin excreted with the milk per day should be far below the dose usually recommended for a newborn child.

Animals↗
PubMed1975

Surgical treatment of ureterocele. A follow-up study of 56 operated cases in 52 adult patients.

A material covering 25 years and comprising 52 patients with 56 surgically treated ureteroceles was followed up over periods varying from 3 to 27 years, the average being 12 years. The initial symptoms and treatment are described. Most of the patients were treated with transurethral diathermy incision of the ureteroceles. 10 patients had died before the follow-up and one could not be located. 73% of the remaining 41 patients had no complaints at follow-up and 71% of the patients treated with transurethral incision were symptomatically cured. Vesico-ureteric reflux was demonstrated in 9 patients, of whom 3 had pyelonephritic changes in the kidneys. The groups of patients treated with resection or excision of the ureteroceles were too small to allow significant conclusions.

Adult↗
PubMed1975

Distribution of labeled antibiotics in different components of milk following intramammary and intramuscular administrations.

In crossover trials, four lactating goats were given intramammary infusions and intramuscular injections of radioactivelabeled benzylpenicillin, spiramycin, chloramphenicol, dihydrostreptomycin, and tetracycline. Milk was collected after each treatment and the antibiotic contents in whole milk, skim milk, and whey were determined microbiologically and radiochemically and in cream and casein by radiochemical assay methods. Uptake of antibiotics by cream and casein was highly dependent on drug concentration, increasing with the decrease in antibiotic content in whole milk. Lipophilic chloramphenicol and tetracycline were concentrated in cream to a higher degree than the less lipophilic benzylpenicillin and dihydrostreptomycin. Antibiotic uptake by cream separated from whole milk after intramuscular injection was higher than after intramammary infusion. Antibiotic uptake by casein was independent of the route of administration and was highest for dihydrostreptomycin and tetracycline and lowest for benzylpenicillin.

Animals↗
PubMed1975

Pharmacokinetics of phenylbutazone and oxyphenabutazone in the pig.

The kinetics of phenylbutazone (pbz) and its main metabolite oxyphenbutazone (oxpbz) were investigated in seven pigs in order to determine if this animal might serve as a model for human investigations. The study was performed in two stages, one as single dose experiments using intravenous injection, the second as infusion experiments. The rate of elimination for both compounds was demonstrated to be much faster than in man. Similar results have been observed in several other animal species. The degree of protein binding (pbz 98%, ox-pbz 97%), the apparent specific volume of distribution (pbz 0.18 1/kg, ox-pbz 0.28 1/kg) and the renal clearance were found to be similar to results obtained in man and rat. Ox-pbz had a higher renal clearance (0.13 ml/min/kg) than pbz (0.003 ml/min/kg) but still the renal excretion constituted only a small fraction of the total elimination (pbz 0.5%, ox-pbz 5%). Provided real steady state conditions were obtained during the infusion experiments calculations based on the results from the single dose experiments in the same animal revealed that between 20 and 60% of the injected pbz was metabolized to the ring-hydroxylation product (ox-pbz). It is concluded that the pig model is not superior to other animal models for studies of pbz/ox-pbz. The rapid elimination pattern is the main problem in relation to human investigations.

Animals↗