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Biomedical subjects

F Pontonnier

Publications and source records attributed to F Pontonnier.

At least 91 records · Page 5Linked to original sources

[Parenteral hyperalimentation and cystoprostatectomy for carcinoma of the bladder (author's transl)].

The authors report a series of 16 total cystoprostatectomies with only one postoperative death. Eleven of these operations, performed with the intention of achieving a complete cure, were carried out after flash radiotherapy of 1.000 rads on the day before surgery and were completed by uretero-sigmoidostomy. The five palliative operations were completed by direct bilateral cutaneous ureterostomy, the patients having received preoperative radiotherapy of 5 to 6,000 rads. The authors attribute the low postoperative mortality to the value of the energy and protein provided by parenteral hyperalimentation which made it possible to administer to the patient from the day after surgery onwards 1,400 to 2,600 calories per day (60% as carbohydrate and 40% as lipids) and 1 gram/kilo of protein per day. Infusion catheters were inserted under strictly aseptic conditions on the day prior to surgery into the deep main veins by percutaneous puncture of a subclavian vein or cutdown of an external jugular vein, and were kept in place until such time as oral alimentation could ensure an equivalent intake. For the 11 patients undergoing curative surgery, weight loss at the time of discharge was no more than 1 to 2 kilos, a figure to be contrasted with the 7 to 8 kilos before the use of parenteral hyperalimentation. The only death occurred amongst the 5 patients undergoing palliative surgery. In the latter group, the authors were stuck by the uncomplicated postoperative course, and the control of complications such as intestinal obstruction or bacteraemia which was obviously better in veiw of the maintenance of the calorie reserves of the body. All parenteral hyperalimentation was administered in the form of commercial solutions and emulsions.

Aged↗

[A summary of the results of microsurgical exploration and treatment. 40 cases of male sterility (author's transl)].

The authors report their statistical results of 40 subjects that were explored and where double epididymo-deferens anastomoses were achieved. They found that there were associated conditions which worsened the prognosis, namely: stenosis of the genital tracts and broncho-pulmonary infections. On the other hand stenosis of the genital tracts associated with varicocoele gave a better prognosis. Permeability was achieved in 40 p. 100 of cases. Six pregnancies occured from 33 patients who were followed up with post-operative spermograms. The following treatments are useful if added to the surgical treatment: gonadotrophins, corticoids and antibiotics. They point out that surgical cure is much more likely when varicocoele is associated.

Bronchiectasis↗

[The results of two years of artificial insemination (author's transl)].

Artificial insemination donor (AID) is the solution for the sterility of many couples where the man is irreversibly sterile. We present the results of AID using frozen sperm in the two first years of work at the Centre d'Etudes et de Conservation du Sperme (C.E.C.O.S.), which is situated in the Midi-Pyrénées region of France. The results that have been obtained are satisfactory and prove the value of this method, but the means at present at the disposal of the Center do not always meet the demands made on it.

Adult↗

Sperm morphology in fertile men and its age related variation.

The different kinds of abnormalities of spermatozoa and their age related variations are studied in a population of 214 fertile men. Coiled tails (7%), bent tails (5.2%), thin heads (2.6%), microcephalic (2.6%), cytoplasmic droplets (2.5%), irregular heads (2%), macrocephalic (0.9%), duplicated heads (0.7%) and duplicated tails (0.5%) are found in this order. Age is positively correlated with the percentage of microcephalic, macrocephalic and duplicate heads and coiled tails and negatively correlated with the percentage of no tail spermatozoa: these age-related variations are involved in the 90th percentile.

Adult↗

[Catatonia de novo, report on a case: immediate vital prognosis and psychiatric prognosis in longer term].

We report on the case of a 20 year old woman with no previous psychiatric history, who displayed a first episode of catatonia with acute onset. Symptoms started plainly with sudden general impairment, intense asthenia, headache, abdominal pain and confusion. After 48 hours, the patient was first admitted to an emergency unit and transferred to an internal medicine ward afterwards. She kept confused. Her behaviour was bizarre with permanent swinging of pelvis, mannerism, answers off the point and increasingly poor. The general clinical examination was normal, except for the presence of a regular tachycardia (120 bpm). The paraclinical investigations also showed normal: biology, EEG, CT Scan, lumbar puncture. Confusion persisted. The patient remained stuporous, with fixed gazing and listening-like attitudes. She managed to eat and move with the help of nurses but remained bedridden. The neurological examination showed hypokinaesia, extended hypotonia, sweating, urinary incontinence, bilateral sharp reflexes with no Babinski's sign and an inexhaustible nasoorbicular reflex. The patient was mute and contrary, actively closed her eyes, but responded occasionally to simple instructions. For short moments, she suddenly engaged in inappropriate behaviors (wandering around) while connecting back to her environment answering the telephone and talking to her parents. The patient's temperature rose twice in the first days but with no specific etiology found. During the first 8 days of hospitalization, an antipsychotic treatment was administered: haloperidol 10 mg per os daily and cyamemazine 37.5 mg i.m. daily. Despite these medications, the patient worsened and was transferred to our psychiatric unit in order to manage this catatonic picture with rapid onset for which no organic etiology was found. On admission, the patient was stuporous, immobile, unresponsive to any instruction, with catalepsy, maintenance of postures, severe negativism and refusal to eat. A first treatment by benzodiazepine (clorazepate 20 mg i.v.) did not lead to any improvement. The organic investigations were completed with cerebral MRI and the ruling out of a Wilson's disease. Convulsive therapy was then decided. It proved dramatically effective from the first attempt; 4 shocks were carried out before the patient's relatives ask for her discharge from hospital. The patient revealed she had experienced low delirium during her catatonic state. The clinical picture that followed showed retardation with anxiety. She was scared with fear both for the other patients and the nursing team. She kept distant and expressed few affects. The treatment at the time of discharge was olanzapine 10 mg per os. She was discharged with a diagnosis of catatonia but with no specific psychiatric etiological diagnosis associated. She discontinued her follow-up a few weeks later. After one year, we had no information about her. Catatonia has now become rare but remains a problem for clinicians. We reviewed data concerning short term vital prognosis and psychiatric long term prognosis in catatonia. Lethal catatonia is associated with acute onset, both marked psychomotor and neurovegetative symptoms. In the light of literature, there is no proband clinical criterion during the episode that is of relevant diagnostic value to ascertain the psychiatric etiology.

Acute Disease↗

[Plasma concentrations and urinary excretion of gonadotropins in azoo and oligospermia. Relationship with spermatogenesis and plasma concentration of androgens (author's transl)].

Plasma concentrations and urinary excretions rate of gonadotropins, testosterone, delta 4-androstenedione, dehydroepiandrosterone and 17 and 17 alpha-hydroxyprogesterone plasma concentrations have been studied in 69 patients with oligo or azoospermia and compared with results obtained in 30 normal control subjects. A sperm count and a caryotype have been done in all patients and a testicular biopsy in 35. Analysis of the histo-hormonal correlations does not show a particular stage of spermatogenesis associated with a modification in FSH production. There is a quantitative relationship between spermatogenesis and FSH production. Plasma testosterone is low and LH production normal in excretory azoospermia. In the other patients plasma testosterone is also low but associated with an increased production of LH. Finally there is a direct relationship between urinary excretion of LH and FSH in both normal subjects and patients, suggesting a modulation by specific factors of a common regulation of the secretion of both gonadotropins.

Adult↗