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Biomedical subjects

F Picard

Publications and source records attributed to F Picard.

At least 163 records · Page 9Linked to original sources
PubMed1980

[Late prenatal diagnosis of fetal growth retardation: the diagnosis of a case of trisomy 18 (author's transl)].

The authors were able to confirm when dealing with a case of severe intra-uterine growth retardation that they were dealing with a case of trisomy 18 when they suspected a positive sign of growth retardation and carried out a pre-natal diagnostic test at the 32nd week of the pregnancy. They point out that this new indication could avoid unnecessary Caesarean operations.

Adult↗
PubMed1978

[Urinary evaluation of 5-S-cysteinyldopa and seric evaluation of IgG4 subclass during follow-up of 27 primitive malignant melanomas (author's transl)].

27 patients with SSM or NM level IV and V have been submitted to a monthly evaluation of their level of 5-S-cysteinyldopa in the urine and IgG4 subclass in their sera. For 5 patients who entered the stage II of their disease during the follow-up, 3 had elevation of the 5S and 5 had large variations of IgG4. On 21 patients in clinical remission, 10 had conjunctly an increase of 5S and variations of IgG4. The predictional value of these tests is discussed.

Cysteinyldopa↗
PubMed1977

[Testing synergism between ethinyl estradiol and norethisterone on the histamine-induced deciduoma and vaginal mucification of castrated rats].

Through the histaminic deciduoma test and a vaginal mucification test, we have endeavoured to show that, in spayed female rats there exists a possibility of synergism between ethynylestradiol and pure norethisterone per os. No synergism could be shown in the former test, owing to, or so it seems, a lack of deciduogenic power proper to norethisterone. The latter test showed, indeed, that ethynylestradiol can, in low quantities, bring about a synergism on the mucifying properties of norethisterone, whereas, in large quantities, it creates an antagonism on the aforesaid properties.

Animals↗
PubMed1977

[Synergistic effects of ethynylestradiol and norethisterone on the formation and lengthening of uterine lace in immature rabbits].

We have shown, through a test proceeding from the McPhail test, in the immature rabbit female, the existence of succession and simultaneity synergisms between ethynylestradiol and pure or impure norethisterone, given by oral route. The estrogen, administrated before the progestative, is able to potentialize the action of the latter on the building of the endometrial lace in 5 days, more than on the lengthening of it in 15 days. Ethynylestradiol, absorbed with norethisterone, strengthens the effects of the latter on the second phenomenon more than on the first one. Absolute and relative doses of the estrogen and of the progestative differ only lightly according as norethisterone is pure or not pure, because of the more potent estrogenicity of the impure norethisterone.

Aging↗
PubMed1977

[The descendants of 47, XYY subjects. Apropos of a family].

Having come across a family where the wife of a father who had 47 XYY chromosomes had 5 pregnancies, of which 3 were pathological (one case of anencephaly and spina bifida, one early abortion, one stillborn girl) the authors reviewed the literature concerning the lineage of parents with 47 XYY chromosomes. We have details of a total of 34 subjects who had this caryotype. 10 of them were sterile (30 per cent) and 10 (30 per cent) had a pathological lineage. Only 14 subjects (40 percent) gave rise to a line of normal descendants. The authors discuss the mechanism by which this caryotype (47 XYY) might be transmitted. They point out that so far only few cases have been published and conclude that it is important that many details about this subject should be published so that worthwhile genetic counselling will later be able to be carried out.

Abortion, Spontaneous↗
PubMed1975

Cytotoxicity of lymphocytes from healthy subjects and from melanoma patients against cultured melanoma cells.

The in vitro cytotoxicity of lymphocytes from forty-seven melanoma patients and thirteen healthy subjects for cultured melanoma cells was studied using a 51Cr release assay. Two different melanoma cell lines were used as target cells: one cultured in suspension (SK Mel1) and one tissue culture line growing as a monolayer (NK I1). The lymphocytes from most healthy subjects were found to be cytotoxic for these cultured cells, with individual variations. These repeatable cytotoxic reactions could not be explained on the grounds of previous isoimmunization. The lymphocytes from melanoma patients were also cytotoxic for the melanoma cell lines, but the highest degree of cytotoxicity was found in patients with primitive and localized tumours, and not in patients with metastases.

Cytotoxicity Tests, Immunologic↗
PubMed1975

[Effects of ethinyl estradiol compared with norethisterone (pure or contaminated) on vaginal keratinization of castrated rats].

Norethisterone samples are often contaminated by estrogen traces which can be measured by mass spectrometry and which invest the progestative with estrogenic properties in the Allen and Doisy test. Therefore, one had better, in pharmacodynamic experimenting, use samples that have been purified by chromatography or that are pure out of synthesis. However, one will not forget these are not without some estrogenicity, a fact which seems linked to the very nature of the norethisterone molecule.

Animals↗