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Biomedical subjects

F Pereira

Publications and source records attributed to F Pereira.

82 records · Page 5Linked to original sources
PubMed1978

Granulopoiesis in chronic myeloproliferative disorders in children.

Four children with chronic myeloproliferative disorders (three with Philadelphia [Ph1] chromosome-positive chronic myelogenous leukemia [CML] were studied with soft agar culture at diagnosis (before therapy) in an attempt to define abnormalities in granulopoiesis. The three patients with CML had elevated peripheral blood golony-forming cells (CFCs) and/or normal or decreased bone marrow CFCs (in those studied). Colony-stimulating activity (CSA) was markedly decreased or absent at diagnosis in all three. Maturation of myeloid cells eithin the colonies in agar was normal, indicating that no block in myeloid maturation was present. These findings are in general agreement with results previously reported in untreated adults with Ph1 chromosome-positive CML and further define the similarity with the adult form of the disease. One Ph1 chromosome-negative patient with a clinically similar chronic myeloproliferative disorder was studied and had similarly elevated peripheral blood CFCs. She had normal CSA with a similarly high WBC count. This finding was unexpected and suggests that, unlike the patients with CML, her monocytes were capable of elaboration CSA. This difference might prove helpful in the classification of this type of disorder in cases where the Ph1 chromosome abnormality is not present.

Adolescent↗
PubMedDate not supplied

Ultrasound biomicroscopic imaging of posterior chamber phakic intraocular lens.

BACKGROUND: Phakic intraocular lens (IOL) implantation represents a major technique for the correction of high myopia. The STAAR collamer posterior chamber phakic IOL--trade named Implantable Contact Lens--is an emerging technology in refractive surgery. We studied the relative position of the posterior chamber phakic IOL using ultrasound biomicroscopy. METHODS: The posterior chamber phakic intraocular lens was inserted in 9 eyes of 8 patients with high myopia. Ultrasound biomicroscopy was performed before and after implantation of the phakic IOL to assess its relative position in the anterior segment of the eye. The parameters measured and compared were anterior chamber depth, angle opening distance 500 microns from the scleral spur, iris-crystalline lens contact distance, iris-IOL contact distance, and IOL-crystalline lens distance. RESULTS: Ultrasound biomicroscopy showed contact between the iris and the IOL in all eyes and between the IOL and the crystalline lens in 8 eyes. Reduction in the anterior chamber depth and localized narrowing of the angle opening were observed in all eyes. CONCLUSION: IOL-iris touch, IOL-crystalline lens touch, and anterior chamber shallowing raise concerns of pigmentary dispersion, cataractogenesis, and narrow angle glaucoma following posterior chamber phakic intraocular lens implantation. Clinical data are needed to determine if these problems occur.

Adult↗
PubMedDate not supplied

[Acute lymphoblastic leukemia in childhood. A 10-year experience with the DFCI 81-01 protocol].

Acute lymphoblastic leukemia is the most frequently encountered pediatric cancer. Approximately 70% of cases can be cured of the disease. In this article, we describe the experience of our Center in the last ten years with a treatment protocol adapted from protocol DFCI 81-01 (from the Dana Farber Cancer Institute, Boston). We conclude that it is easily accomplished, well tolerated and that it allowed us to significantly improve the outcome of our patients (80% 5 year-survival). Nevertheless, we are currently in the process of changing to a new protocol--one that will hopefully achieve a comparable cure rate with less long-term toxicity.

Adolescent↗
PubMedDate not supplied

[The Calmette-Guérin bacillus (BCG). An agent to consider in pediatric infection].

Complications occurring a long time after BCG vaccination in healthy children have been occasionally referred, despite being rare. Osteitis seems to be the most frequent of those complications; therefore it must be considered in the differential diagnosis of that sort of lesions. The authors report a case of a 15 month old boy, previously healthy, who suffered an enlargement of the right foot for 3 weeks, unresponsive to antibiotics. The lesion revealed to be osteitis due to bacillus Calmette-Guérin, and abated after specific treatment.

BCG Vaccine↗