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Biomedical subjects

F Numano

Publications and source records attributed to F Numano.

At least 235 records · Page 13Linked to original sources
PubMed1975

Immunofluorescent demonstration of plasma protein entry into arterial wall by cholesterol, epinephrine, norepinephrine and angiotensin II.

Thepresence of IgG and beta-lipoprotein in thoracic and abdominal aortas of 33 rhesus monkeys under various conditions was observed by immunofluorescence and interference filter technique. In untreated and placebo control monkeys, a definite fluorescence due to IgG was seen in highly limited areas of the subendothelial space and the innermost layers and a weak but positive fluorescence due to beta-lipoprotein was sometimes show in highly limited spots of the subendothelial space, but not the medial layers. In challenged animals with cholesterol (1 g/kg p.o.) or epinephrine (1 mug/kg i.v.) or norepinephrine (10 mug/kg i.v.) or angiotensin II (1 mug/kg i.v.) or cholesterol (1 g/kg p.o.) plus epinephrine (1 mug/kg i.v.), definite fluorescence showing the entry of beta-lipoprotein and IgG from the vessel lumen into the subendothelial space and then into the medial layers of the arterial wall was clearly shown by serial sacrificing of animals after each challenge. The passage of beta-lipoprotein through the internal elastic lamina into the medial layer, was characteristically delayed as compared with that of IgG. In pretreated animals with pyridinolcarbamate (PDC) (10 mg/kg p.o.), EG467 (1 mg/kg p.o.) and Premarin (5 mg/kg i.v.), the acute entry of those plasma proteins was significantly inhibited.

Angiotensin II↗
PubMed1975

Blood zinc levels in patients with arteriosclerosis obliterans, thromboangiitis obliterans and Takayasu's disease.

Serum zinc concentration was measured by atomic absorption spectrophotometry in 30 normal males, 17 normal females, 20 patients with arteriosclerosis obliterans, 26 patients with thromboangiitis obliterans, 40 patients with Takayasu's disease. The mean serum zinc concentration was 93.9 +/- S.E.4.0 mug/100 ml in the normal male controls, 75.1 +/- 3.3 mug/100 ml in patients with arteriosclerosis obliterans without ulcers (P less than 0.05) and 79.2 +/- 6.5 mug/100 ml in patients with thromboangiitis obliterans without ulcers. Serum zinc concentration showed to be more decreased in patients with these diseases who had ulcers. The mean serum zinc concentration was 77.9 +/- 4.0 mug/100 ml in the normal female controls, 71.8 +/- 5.1 mug/100 ml in patients with Takayasu's disease who had never been treated with steroids and 59.1 +/- 2.7 mug/100 ml in patients with this disease who had been treated with this drug (P less than 0.01). The zinc level was significantly lower in CRP positive patients with Takayasu's disease than in CRP negative patients (P less than 0.05).

Adult↗