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Biomedical subjects

F Niedobitek

Publications and source records attributed to F Niedobitek.

At least 55 records · Page 3Linked to original sources
PubMed1987

[Long-term studies of colonization of the gastric mucosa by Campylobacter pyloridis].

Multiple biopsy specimens of gastric mucosa of 15 patients taken at different intervals with an observation period of 4 to 20 years were evaluated. Histological examination revealed superficial gastritis in most cases without radical and progressive destruction of the mucosa and in all but one case the presence of CLO was demonstrated with varying degree of intensity. No evidence was found for causal relationship between bacterial colonization and inflammation.

Adult↗
PubMed1986

[Comparative studies of IgE content of the gastric mucosa in various forms of gastritis].

The problem of the pathogenetic significance of IgE-mediated inflammatory processes in simple unspecific gastritis was studied in mucosal biopsies of 396 cases with unequivocal histological classification. The results demonstrate that only in acute and erosive gastritis high IgE cell counts are found, thus, indicating a pathogenetic significance. Furthermore the statistical evaluation showed a parallel age distribution of IgE containing cells in the four biopsy groups. Mucosal biopsies from patients 40-65 years of age exhibited higher IgE cell counts than younger and older persons. These results suggest that there is a higher IgE-reactivity in the middle age.

Adult↗
PubMed1985

[Diagnostic problems of virus-induced atypical squamous cell proliferations in the area of the anus and genitalia. A case report on Bowenoid papulosis].

Papillomatous proliferations of squamous epithelium of the genital and anal region termed Bowenoid Papulosis (BP) macroscopically resemble condylomata acuminata, whereas histologically they show in part severe dysplasias. Despite the similarity of these lesions to Bowen's disease they are - like condylomas - induced by papilloma viruses and may regress spontaneously. Condyloma-like but predominantly flat proliferations of squamous epithelium of the transitional zone between exocervix and endocervix, which are likewise caused by viruses and have a prognosis similar to that of BP, are even more problematic in differential diagnostic differentiation from cervical carcinoma in situ. Both these atypical proliferations of squamous epithelium of the exocervix referred to as "flat condylomas" and BP contain koilocytes as a sign of cell regression relatively typical of virus-induced cell change. In a reported case of a 38-year old woman with widespread BP of the ano-genital region intranuclear papilloma virus antigen could be demonstrated immunohistochemically in the papillomatous proliferations of squamous epithelium and furthermore in sections made from the filed paraffin blocks of a cone biopsy taken five years ago. In two of altogether seven cases of BP presented in tables papilloma virus antigen could be shown as well. In one woman of already 54 years of age widespread BP is described more comprehensively, because due to the feature of inverted papillomatosis carcinoma was suspected clinically. BP and flat condylomas have been defined as terms only in recent years and - as virus-induced lesions - been differentiated from carcinoma in situ on account of a more favourable prognosis.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1985

[Histologic and mucin histochemistry studies on the topic of so-called transitional mucosa in the vicinity of large intestine cancers].

Morphological analysis of the mucosal change of the large bowel called "transitional mucosa"; 38 resection specimens with colonic carcinoma and 14 specimens with non malignant changes for control were studied. The "transitional mucosa" is described as the sum of histological, cytological and mucin histochemical findings forming a characteristic mucosal pattern in the vicinity of the carcinomatous lesion in all cases but in one. However, the expression of the single morphological finding is variable and all characteristics of the mucosal alteration were also found frequently in the control group without malignant tumours. Therefore the diagnostic value of the "transitional mucosa" for early recognition of large bowel carcinoma is negligible. The pathogenesis of this lesion remains unclear but is discussed as a reactive hyperplasia of the mucosal crypts caused by a change of the large bowel contents initiated probably by a long-standing motility disturbance.

Aged↗
PubMed1981

[Chronic pulmonary cryptococcosis. A case contribution for diagnosis of cryptococcosis in man from a pathologic-anatomic viewpoint].

Routine use of differential nutrients for isolating cryptococcus neoformans (Staib-Agar) during post-mortem examination revealed previously unsuspected chronic pulmonary cryptococcosis in a 64-year-old woman. Cause of recurrent pleural effusions over three years were probably sub-pleural cryptococcomas. In on-target and specific search for the cryptococcosis pathogen, the lung deserves special attention as a probable gateway.

Autopsy↗
PubMed1977

On the incidence of malignant tumors in routine autopsies.

The present study taken over a 12-year time period analyzes malignant tumors in a large number of autopsies, with specific consideration of the frequency and location, age and sex group distribution, and histologic classification of the tumors. The tumors were first evaluated in terms of specific organs and organ systems and were then histologically classified. On a total of 23338 subjects who died between the years 1960 and 1971, 17052 autopsies were carried out (73.1%) and only 15384 (65.9%) of these were evaluated for out study. Altogether we located 4911 cases of MT, i.e., 31.9% of the evaluated autopsies. The number of MT in the males slightly exceeded that in the females (2508[51.1%] MT and 2403 [48.9%] MT, respectively.) We calculated over 60% of the MT to be in the 7th and 8th age groups. By comparing the two time periods (1960-1965) and 1966-1971) we calculated a significant increase in the MT rate by 1.7%. This increase was found mainly to effect the males (the female group showed only a slight increase). The greatest number of MT were located in the digestive system with an MT rate of 26.2%; next came the urogenital system (23.4%) and then the respiratory system (18.7%). The respiratory system took first position of importance in the males with an MT rate of 30.3% followed by the digestive system with 27.4%. The urogenital system dominated in the females with a rate of 29.0%. The rate of MT of the respiratory system was significantly higher in the males...

Adolescent↗
PubMed1977

[Morphometric studies on epithelial cells of the rat stomach under chronic effect of alcohol].

In studying the effect of ethanol on the size of parietal cells 60 Wistar rats received 15% ethanol ad libitum and were killed after 8 days, 2, 4, 8, and 12 weeks. For the control group 24 untreated animals were used. The parietal cells were stained with Kongo-red for the histological preparations and with a Papanicolaou modification for the cytological smear. With two measuring-methods -- the Integration-disc and the Mikrovideomat -- the cell and nucleus surface were determined and the nucleus-plasma-relation was calculated. After 8 days of alcohol administration a significant increase of parietal cell surface appeared in the histological and cytological preparation. The cytoplasma surface area increased continuously until the 8th week. With further application of alcohol until the 12th week the zytoplasma surface area decreased again but remained above the starting size. The calculation of the cell surface areas produced nonuniform results. Further the sizes of parietal cells (cytoplasma and nucleus surface areas) in the cytological smear and after being embedded in the histological preparation were compared. In the applied measuring methods a comparison was also made.

Animals↗