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Biomedical subjects

F Moss

Publications and source records attributed to F Moss.

At least 55 records · Page 3Linked to original sources
PubMed1997

Low-dimensional dynamics in sensory biology. 1: Thermally sensitive electroreceptors of the catfish.

We report the results of a search for evidence of periodic unstable orbits in the electroreceptors of the catfish. The function of these receptor organs is to sense weak external electric fields. In addition, they respond to the ambient temperature and to the ionic composition of the water. These quantities are encoded by receptors that make use of an internal oscillator operating at the level of the membrane potential. If such oscillators have three or more degrees of freedom, and at least one of which also exhibits a nonlinearity, they are potentially capable of chaotic dynamics. By detecting the existence of stable and unstable periodic orbits, we demonstrate bifurcations between noisy stable and chaotic behavior using the ambient temperature as a parameter. We suggest that the technique developed herein be regarded as an additional tool for the analysis of data in sensory biology and thus can be potentially useful in studies of functional responses to external stimuli. We speculate that the appearance of unstable orbits may be indicative of a state of heightened sensory awareness by the animal.

Animals↗
PubMed1996

Characterization of low-dimensional dynamics in the crayfish caudal photoreceptor.

Attempts to detect and characterize chaos in biological systems are of considerable interest, especially in medical science, where successful demonstrations may lead to new diagnostic tools and therapies. Unfortunately, conventional methods for identifying chaos often yield equivocal results when applied to biological data, which are usually heavily contaminated with noise. For such applications, a new technique based on the detection of unstable periodic orbits holds promise. Infinite sets of unstable periodic orbits underlie chaos in dissipative systems; accordingly, the new method searches a time series only for rare events characteristic of these unstable orbits, rather than analysing the structure of the series as a whole. Here we demonstrate the efficacy of the method when applied to the dynamics of the crayfish caudal photoreceptor (subject to stimuli representative of the animal's natural habitat). Our findings confirm the existence of low-dimensional dynamics in the system, and strongly suggest the existence of deterministic chaos. More importantly, these results demonstrate the power of methods based on the detection of unstable periodic orbits for identifying low-dimensional dynamics--and, in particular, chaos--in biological systems.

Action Potentials↗
PubMed1996

Detecting low dimensional dynamics in biological experiments.

We discuss the well-known problems associated with efforts to detect and characterize chaos and other low dimensional dynamics in biological settings. We propose a new method which shows promise for addressing these problems, and we demonstrate its effectiveness in an experiment with the crayfish sensory system. Recordings of action potentials in this system are the data. We begin with a pair of assumptions; that the times of firings of neural action potentials are largely determined by high dimensional random processes or "noise"; and that most biological files are non stationary, so that only relatively short files can be obtained under approximately constant conditions. The method is thus statistical in nature. It is designed to recognize individual "events" in the form of particular sequences of time intervals between action potentials which are the signatures of certain well defined dynamical behaviors. We show that chaos can be distinguished from limit cycles, even when the dynamics is heavily contaminated with noise. Extracellular recordings from the crayfish caudal photoreceptor, obtained while hydrodynamically stimulating the array of hair receptors on the tailfan, are used to illustrate the method.

Action Potentials↗
PubMed1996

Light enhances hydrodynamic signaling in the multimodal caudal photoreceptor interneurons of the crayfish.

1. The caudal photoreceptor (CPR) interneurons in the sixth abdominal ganglion of the crayfish are complex, multi-modal interneurons. These cells respond directly to light with tonic spike discharges, and they integrate synaptic input from an array of fili-form mechanoreceptors on the tailfan. They also provide input to rostral command centers, inducing backward walking at high firing frequencies, and thus directly influence behavior. 2. We recorded CPR activity in response to weak hydrodynamic stimulation of the tailfan mechanoreceptors while under varying intensities of light shined on the sixth ganglion. Spike trains were characterized according to the mean discharge rate (MDR) and the power spectrum from which the signal-to-noise ratio (SNR) was calculated. 3. Illumination of the CPR enhances the efficiency of transmitting mechanosensory signals. It does so by increasing the SNR of mechanosensory input received from tailfan receptors. A sevenfold, nonlinear increase in the SNRs was observed with increasing light intensity, an effect especially pronounced for weak hydrodynamic stimuli. In comparison with the dark, illumination of the ganglion lowered the hydrodynamic threshold and heightened the response to suprathreshold stimulation. Unlike the SNR, the MDR is little affected by mechanosensory input. 4. These results are compared with simulated electronic activity from an analogue threshold model and are discussed with respect to the mechanism of stochastic resonance.

Animals↗
PubMed1995

Alternative models of organisation are needed.

Anyone considering a fundamental rethink of the role of consultants risks exposing tensions in the medical profession that have characterised the development of medical practice since the 18th century. That tense story was one of beds and money, power and domination. Rethinking the role of consultants must now take into account the relationship between consultants and their specialist colleagues and general practitioners; examine the distribution of work between consultants and junior doctors; and relate the contribution of the consultant as specialist to that of other health professionals. After half a century of a national health service characterised by equity of access to care, we urgently need to debate the roles of those who work in it and in doing so to focus primarily on the needs of patients.

Ambulatory Care↗
PubMed1995

Stochastic resonance and the benefits of noise: from ice ages to crayfish and SQUIDs.

Noise in dynamical systems is usually considered a nuisance. But in certain nonlinear systems, including electronic circuits and biological sensory apparatus, the presence of noise can in fact enhance the detection of weak signals. This phenomenon, called stochastic resonance, may find useful application in physical, technological and biomedical contexts.

Animals↗