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Biomedical subjects

F Moss

Publications and source records attributed to F Moss.

At least 37 records · Page 2Linked to original sources
PubMed1999

Surrogates for finding unstable periodic orbits in noisy data sets.

Recently, searches for unstable periodic orbits in biological and medical applications have become of interest. The motivations for this research range, in order of ascending complexity, from efforts to understand the dynamics of simple sensory neurons, through speculations regarding neural coding, to the hopeful development of new diagnostic and/or control techniques for cardiac and epileptic pathologies. Biological and medical data are, however, noisy and nonstationary. Findings of unstable periodic orbits in such data thus require convincing assessments of their statistical significance. Such tests are accomplished by comparison with surrogate data files designed to test an appropriate null hypothesis. In this paper we test surrogates generated by three different algorithms against correlated noise as well as stable periodic orbits. One of the surrogates is new, and has been specifically designed to preserve the shape of the attractor. We discuss the suitability of these surrogates and argue that the simple shuffled one correctly tests the appropriate null hypothesis.

Journal Article↗
PubMed1999

Synchronization of noisy systems by stochastic signals.

We study, in terms of synchronization, the nonlinear response of noisy bistable systems to a stochastic external signal, represented by Markovian dichotomic noise. We propose a general kinetic model which allows us to conduct a full analytical study of the nonlinear response, including the calculation of cross-correlation measures, the mean switching frequency, and synchronization regions. Theoretical results are compared with numerical simulations of a noisy overdamped bistable oscillator. We show that dichotomic noise can instantaneously synchronize the switching process of the system. We also show that synchronization is most pronounced at an optimal noise level-this effect connects this phenomenon with aperiodic stochastic resonance. Similar synchronization effects are observed for a stochastic neuron model stimulated by a stochastic spike train.

Journal Article↗
PubMed1998

Human autoantibodies specific for the alpha1A calcium channel subunit reduce both P-type and Q-type calcium currents in cerebellar neurons.

The pharmacological properties of voltage-dependent calcium channel (VDCC) subtypes appear mainly to be determined by the alpha1 pore-forming subunit but, whether P-and Q-type VDCCs are encoded by the same alpha1 gene presently is unresolved. To investigate this, we used IgG antibodies to presynaptic VDCCs at motor nerve terminals that underlie muscle weakness in the autoimmune Lambert-Eaton myasthenic syndrome (LEMS). We first studied their action on changes in intracellular free Ca2+ concentration [Ca2+]i in human embryonic kidney (HEK293) cell lines expressing different combinations of human recombinant VDCC subunits. Incubation for 18 h with LEMS IgG (2 mg/ml) caused a significant dose-dependent reduction in the K+-stimulated [Ca2+]i increase in the alpha1A cell line but not in the alpha1B, alpha1C, alpha1D, and alpha1E cell lines, establishing the alpha1A subunit as the target for these autoantibodies. Exploiting this specificity, we incubated cultured rat cerebellar neurones with LEMS IgG and observed a reduction in P-type current in Purkinje cells and both P- and Q-type currents in granule cells. These data are consistent with the hypothesis that the alpha1A gene encodes for the pore-forming subunit of both P-type and Q-type VDCCs.

Animals↗
PubMed1998

Noise-induced spiral waves in astrocyte syncytia show evidence of self-organized criticality.

Long range (a few centimeters), long lived (many seconds), spiral chemical waves of calcium ions (Ca2+) are observed in cultured networks of glial cells for normal concentrations of the neurotransmitter kainate. A new method for quantitatively measuring the spatiotemporal size of the waves is described. This measure results in a power law distribution of wave sizes, meaning that the process that creates the waves has no preferred spatial or temporal (size or lifetime) scale. This power law is one signature of self-organized critical phenomena, a class of behaviors found in many areas of science. The physiological results for glial networks are fully supported by numerical simulations of a simple network of noisy, communicating threshold elements. By contrast, waves observed in astrocytes cultured from human epileptic foci exhibited radically different behavior. The background random activity, or "noise", of the network is controlled by the kainate concentration. The mean rate of wave nucleation is mediated by the network noise. However, the power law distribution is invariant, within our experimental precision, over the range of noise intensities tested. These observations indicate that spatially and temporally coherent Ca2+ waves, mediated by network noise may play and important role in generating correlated neural activity (waves) over long distances and times in the healthy vertebrate central nervous system.

Astrocytes↗
PubMed1998

Effect of nerve block on sural amplitude during remote muscle contraction.

We previously reported that the median sensory nerve action potentials (SNAPs) increased in amplitude during both near (3) and remote (4) muscle contraction. The objective of the present project was to begin to study the pathway by which this occurred. The sural amplitude was measured after one min. of isometric biceps contraction and compared pre and post lidocaine nerve block in 10 healthy subjects. The baseline was defined as the least amount of current needed to elicit a minimal sural response pre contraction. This level of stimulus remained constant throughout the experiment. Results showed that the sural amplitude peaked 4 min. after muscle contraction. An 8.1 microV increase in sural amplitude from baseline was noted pre injection as 5 min. post contraction, and an increase of 13.4 microV was noted comparing pre to post injection amplitudes at the same time. Statistical analysis using two-way interaction comparing the time courses pre and post injection showed a 92% chance the responses were dissimilar Post hoc least significant difference (LSD) analyses were significant at 4 min. (p = .005) and 6 min. (p = 0.29) post contraction. In conclusion, the increase in sural amplitude after remote muscle contraction was no longer apparent after proximal sural nerve block. This suggests that the nerve itself is required in the final common pathway for the transmission of this induced signal.

Action Potentials↗
PubMed1997

Association of use of a log book and experience as a preregistration house officer: interview survey.

OBJECTIVE: To determine whether use of a log book improved the experiences of preregistration house officers. DESIGN: Confidential questionnaire and interview survey of preregistration house officers carried out as part of University of London inspection process. MEASURES: Preregistration house officers were asked to rate educational and pastoral elements of their posts and about the use made of previously distributed log books. SUBJECTS AND SETTING: Preregistration house officers in North Thames. RESULTS: The incumbents of 535 of 560 (95%) preregistration house officer posts in the region were surveyed between June 1994 and July 1995, 490 by questionnaire and interview, 45 by questionnaire alone. House officers who had discussed the log book with their consultant expressed more satisfaction with their induction, consultant supervision and feedback, and formal and informal education and were more likely to recommend their job to a friend. CONCLUSION: Preregistration house officers who had discussed the log book with their consultant expressed more satisfaction with the educational elements of their jobs. The structured discussion with their consultant about the job and their performance seemed to make the difference.

Consultants↗
PubMed1997

Low-dimensional dynamics in sensory biology. 1: Thermally sensitive electroreceptors of the catfish.

We report the results of a search for evidence of periodic unstable orbits in the electroreceptors of the catfish. The function of these receptor organs is to sense weak external electric fields. In addition, they respond to the ambient temperature and to the ionic composition of the water. These quantities are encoded by receptors that make use of an internal oscillator operating at the level of the membrane potential. If such oscillators have three or more degrees of freedom, and at least one of which also exhibits a nonlinearity, they are potentially capable of chaotic dynamics. By detecting the existence of stable and unstable periodic orbits, we demonstrate bifurcations between noisy stable and chaotic behavior using the ambient temperature as a parameter. We suggest that the technique developed herein be regarded as an additional tool for the analysis of data in sensory biology and thus can be potentially useful in studies of functional responses to external stimuli. We speculate that the appearance of unstable orbits may be indicative of a state of heightened sensory awareness by the animal.

Animals↗