Prevention of diisopropylfluorophosphate (DFP)-induced lethality by meptazinol and 9-amino-tetrahydroacridine (THA) in the mouse.
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Acetylcholinesterase↗
Biomedical subjects
F Mori
Publications and source records attributed to F Mori.
[Valvuloplasty for acute mitral insufficiency caused by torn chordae (Carpentier method): report of a case].
A 66-year-old female was admitted to our hospital with acute heart failure (NYHA III), and diagnosed as an MR + Tr. The cause of MR was torn chordae of the posterior leaflet of the mitral valve. A prolapse part of the posterior leaflet was resected and sutured by McGoon's method. Valvuloplasty was performed by using a Carpentier ring. Postoperative course was uneventful. She recovered well after the operation. Histological examination of the valve showed myxomatous degeneration.
Aged↗
Glycine and kynurenate modulate the glutamate receptors in the myenteric plexus and in cortical membranes.
The responses evoked by stimulation of the N-methyl-D-aspartate receptors in the guinea-pig myenteric plexus were potentiated by micromolar concentrations of glycine and were non-competitively antagonized by kynurenate (IC50: 60 microM). The effects of kynurenate were competitively prevented by glycine. Furthermore, kynurenate displaced [3H]glycine from its binding sites on rat cortical membranes (IC50: 20 microM). Kynurenate and glycine, therefore, probably act at the same site, evoking opposite effects on the function of the ion channel complex of the N-methyl-D-aspartate receptor.
2-Amino-5-phosphonovalerate↗
Monitoring the purity of pharmaceutical heparin preparations by high-field 1H-nuclear magnetic resonance spectroscopy.
High-field (300 MHz) 1H NMR spectral analyses are reported for various sodium or calcium heparin products available on the Canadian market. Dermatan sulfate (chondroitin sulfate B) was detected as a contaminant in virtually all of these products. Its content varied among the suppliers from less than 1 to 15%, and also over nearly the same range within the groups of heparin preparations of particular suppliers. No correlation was found between in vitro biological activities (potency and anti-factor Xa by the USP tests) and the levels of dermatan sulfate found. Other components, or unlisted constituents, detected in some preparations were paramagnetic metal ions, polyols, and lidocaine.
Chemical Phenomena↗
Examination of a possible role for dermatan sulfate in the aggregation of commercial heparin samples.
A wide range of commercial heparin preparations were examined by the technique of quasi-elastic light scattering (QELS) for size distribution and evidence for aggregation in relation to determined dermatan sulfate (DS) content. No correlation could be found between DS content and state of aggregation. The possible interaction of DS with heparin was further studied by QELS in a control experiment in which known quantities of DS were added to a heparin sodium preparation known to be low in DS. The effect of increasing DS content was to slightly decrease the measured most probable size of the samples and also to decrease the size spread. The biological activity (as measured by the official test) of the heparin samples, including those treated with additional DS, was found to fall within the accepted limits, independent of the aggregation state of the samples. Overall, there is no direct, observable effect that links DS to the observed aggregation of commercial heparin samples, although DS itself is known to self-associate.
Chemistry, Pharmaceutical↗
Myocardial protection by a left ventricular assist device during reperfusion following acute coronary occlusion.
To evaluate the effects of a left ventricular assist device (LVAD) during the reperfusion period following acute coronary occlusion, sixteen mongrel dog hearts were subjected to 1 hour's occlusion of the circumflex coronary artery and then reperfused for 6 hours. In seven control dogs (control group), the hearts were reperfused without any support. In nine LVAD dogs (LVAD group), however, the left ventricles were supported by the application of a pneumatic driven diaphragm-type pump for 5 hours and then reperfused for another hour without any device. Triphenyltetrazolium chloride was used to determine the extent of infarction. The results showed a significant reduction in the area of infarct (AI) as a percentage of the area at risk (AR) in the LVAD group compared with the control group, the AI/AR being 22.3 per cent for the control group versus 4.8 per cent for the LVAD group (p less than 0.05). The cardiac output was also significantly higher in the LVAD group compared with the control group. The per cent systolic shortening in the ischemic region of the LVAD group showed a significantly better recovery, being 75.8 per cent for the LVAD group versus 24.4 per cent for the control group (p less than 0.01). It was concluded that the application of a LVAD during reperfusion after 1 hour's coronary occlusion results in a significant reduction of infarct size and provides improvement in both regional and global cardiac function.
Animals↗
The effect of fluorocarbon emulsion on 24-hour canine heart preservation by coronary perfusion.
This study was designed to evaluate the effects of fluorocarbon emulsion as an oxygen carrier in myocardial preservation. The hearts were preserved for 24 hours by coronary perfusion with either oxygenated crystalloid cardioplegic solution (group C) or crystalloid cardioplegic solution with fluorocarbon added (group FC). The perfusion pressure was kept at 20 mm Hg, and myocardial temperature was maintained at 4 degrees C. Group FC demonstrated better recovery in developed pressure and maximum rate of rise of left ventricular pressure compared with group C. The postpreservation end-diastolic pressure in group C increased significantly compared with the baseline value (value obtained before preservation). On the other hand, group FC showed no significant increase of end-diastolic pressure after preservation. Group FC released a significantly lower level of creatine kinase into its perfusate than did group C. Ultrastructural changes after preservation in group C showed severe ischemic injury, but there was no evidence of ischemic injury in group FC. The use of fluorocarbon emulsion proved beneficial to myocardial protection in long-term preservation of canine hearts.
Animals↗
Comparison of virulence between two strains of Rattus serotype hemorrhagic fever with renal syndrome (HFRS) virus in newborn rats.
Two strains of hemorrhagic fever with renal syndrome (HFRS) virus from Rattus, SR-11 and KI-262, showed virtually identical antigenicity but differed from prototype strain Hantaan 76-118 (Apodemus origin) in a neutralization test. Wistar newborn rats inoculated intraperitoneally (i.p.) with SR-11, which was isolated from a laboratory rat associated with an outbreak of HFRS, developed clinical signs such as ataxia and limb paralysis and died at about 18 days after inoculation. The LD50 of SR-11 in 1-day-old rats was 10(1.2) focus-forming units (FFU). In contrast, the animals inoculated i.p. or intracerebrally with 10(4) FFU of KI-262, which was from a wild rat in a dumping-ground area--an enzootic focus where no human cases have been recorded--did not show any significant clinical signs. The susceptibility of rats to SR-11 fatal infection was age-dependent. Virus titers in brains, lungs, kidneys, and livers of the rats inoculated with SR-11 were significantly higher than those in the same organs of the animals infected with KI-262. Necrosis of neurons in the brain tissue occurred in the rats infected with SR-11, while it was mild in the animals infected with KI-262.
Aging↗
[The effect of pulsatile perfusion on aortocoronary bypass grafting].
To evaluate the effect of pulsatile perfusion on myocardial protection and peripheral circulation, 23 patients undergoing aortocoronary bypass grafting were studied by dividing two groups; one with pulsatile perfusion technique (11 patients) and the other with non-pulsatile (12 patients). The cardiac functional assessments were made on CI, LVSWI, PCWP, CVP at 3, 6, 12 and 24 hours after the operation and the enzyme (CPK, CPK-MB, LDH, GOT) sampling were performed on 1, 2, 4 and 7 days after the operation. The difference between esophageal and rectal temperature, and urine output during cardiopulmonary bypass, indicating the peripheral circulation, were also measured. From these clinical results, it is concluded that pulsatile perfusion method is to be beneficial in myocardial protection and peripheral circulation during operation of aortocoronary bypass grafting.
Adult↗
[Congenital coronary artery fistula draining into the superior vena cava with giant saccular aneurysm--report of a case].
A 42-year-old woman who had a coronary artery fistula, associated with a giant coronary saccular aneurysm was reported. The coronary artery fistula originated from the proximal portion of the right coronary artery drained into the superior vena cava. The chief complaint was heart murmur which was detected at the 2nd intercostal space of the right sternal border. No other symptoms were present. The aneurysm was approximately 5 X 7 cm in size. In the operation using cardiopulmonary bypass, the proximal and distal portions of the coronary artery fistula were ligated successfully without aneurysmorrhaphy. The postoperative conditions was even without any complications. Congenital coronary artery fistulas with a giant saccular aneurysm should be surgically treated as soon as possible because of potential risk of aneurysmal rupture.
Adult↗
[Early operation for postinfarction ventricular septal perforation; report of three cases].
Three patients underwent surgery for postmyocardial infarction ventricular septal perforation (VSP) within 3 to 21 days after onset of infarction. The hemodynamic stabilization was not obtained despite aggressive medical treatment including Intra-aortic Balloon Pumping (IABP) in one patient. The others had sudden hemodynamic deterioration during IABP support. In two of the three cases, the VSP were closed via transinfarct ventriculotomy with double Dacron patch, and ventricular wall reconstruction was performed to sandwich the double septal patch between ventricular free walls with Dacron felt strips. Two of the three patients survived. Our experience suggests that early surgical intervention is essential unless medical therapy results in clinical improvement and the double patch method may provide a successful operative repair and comeout.
Adult↗
[Transesophageal color-coded Doppler echocardiography: diagnosis of regurgitation of mitral valve prosthesis].
In patients with mechanical mitral prosthesis, the presence of dysfunction and regurgitation of the prosthesis may be difficult to assess by standard precordial color flow Doppler. Moreover, the kind of mitral prosthesis regurgitant jet is often impossible to determine. We have recently studied 4 patients with clinically suspected mitral prosthesis dysfunction. In all of them the conventional transthoracic color flow technique was unable to evidentiate prosthesis regurgitation, whereas the transesophageal color flow Doppler assessed a partial displacement with a peri-prosthetic regurgitation in 3 patients, and a prosthetic endocarditis with intra-prosthetic regurgitation in 1. All studies were performed using an Aloka SSD 860 and 5 MHz transesophageal color Doppler transducer, using a topical anesthesia with 10% lidocaine. The procedure was well tolerated without any complication in all patients. Transesophageal color flow Doppler has specific improved capabilities over transthoracic conventional color flow Doppler and represents an important advance even for the noninvasive evaluation of patients with suspected mitral prosthesis regurgitation.
Adult↗
[Changes in postoperative colloid oncotic pressures after open heart surgery especially in relation to recovery of the hemodynamic and respiratory status].
In order to evaluate the relationship among the changes of colloid oncotic pressure (COP), hemodynamic and respiratory recovery after open heart surgery, cardiac index (CI), pulmonary capillary wedge pressure (PCWP), (A-a)DO2, urine output and COP were measured in 33 patients during 48 hours after the cardio-pulmonary bypass (CPB). The patients were divided into three groups according to COP values at 3 and 24 hours after CPB. Twenty three patients whose COP values were normal (COP greater than or equal to 19 mmHg) at 3 hours after CPB maintained stable hemodynamic and respiratory status. Cardio-respiratory status were deteriorated in the 6 patients whose COP values were below normal both 3 and 24 hours after CPB. On the other hand, 4 patients with normal (A-a)DO2 and low COP values at 3 hours after CPB demonstrated rapid recovery of COP values and improvement of cardiac function. It is concluded that the patients with both cardiac and respiratory dysfunction have low COP values during 48 hours after CPB, but the patients with normal (A-a)DO2 and low COP at 3 hours after CPB demonstrate the recovery of COP values with rapid improvement of cardiac function until 24 hours after open heart surgery.
Cardiopulmonary Bypass↗
[Surgical considerations after patch closure of atrial septal defect with tricuspid annuloplasty].
Two patients with complications of embolism during the early postoperative period after patch closure of atrial septal defect with tricuspid annuloplasty were reported. Case 1: A 58-year-old woman underwent closure of an atrial septal defect and tricuspid annuloplasty by means of Kay's technique for tricuspid regurgitation. She had an episode of thromboembolism in the bilateral common femoral arteries 7 days after surgery. Thromboembolectomy was performed successfully using Fogarty's embolectomy catheter. Case 2: A 49-year-old woman underwent closure of an atrial septal defect and the tricuspid annuloplasty using Carpentier ring for tricuspid regurgitation. The patient had transient left hemiparesis on the 5th postoperative day. Both patients had atrial fibrillation and mild pulmonary hypertension before surgery. In relatively old patients (over 40 years old) with atrial septal defect, tricuspid regurgitation and atrial fibrillation, anticoagulant therapy should be started immediately after surgery to prevent thromboembolism.
Female↗
Sera from patients with multiple sclerosis react with human T-cell lymphotropic virus-I GAG proteins: Western blotting and solid-phase radioimmunoassay analyses.
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Blotting, Western↗
[Levels of plasma cyclic AMP in cardiac surgery].
The actions of hormones such as catecholamines, vasopressin and growth hormones are mediated by a common intracellular second messenger, cyclic AMP (adenosine 3',5'-monophosphate). The effects of cardiac surgery on plasma cyclic AMP were studied in 32 adults patients with aorta-coronary bypass or with valvular disease. Blood specimens were obtained before operation, at the beginning and at the end of the cardiopulmonary bypass, 1, 3, 6, 9, 12, 24, 48, 72, 168 hours after surgery. The plasma cyclic AMP level during cardiac operation was elevated above the preoperative level. High levels of plasma cyclic AMP were found both in the aorta-coronary bypass and in the valvular disease immediately after the end of cardiopulmonary bypass. The plasma cyclic AMP level in patients undergoing aorta-coronary bypass with aortic clamping time more than 60 minutes was 38.6 +/- 11.7 pmol/ml, compared to 25.6 +/- 6.6 pmol/ml with aortic clamping time less than 60 minutes immediately after the end of cardiopulmonary bypass. In patients undergoing valve replacement and/or commissurotomy with aortic clamping time more than 60 minutes, the plasma cyclic AMP level immediately after the end of cardiopulmonary bypass was 113 +/- 63.3 pmol/ml, compared to 45.4 +/- 10.3 pmol/ml with aortic clamping time less than 60 minutes (p less than 0.01, Student's t test). During 24 hours after cardiac surgery, the plasma cyclic AMP concentration returned to normal range. It is considered that the plasma cyclic AMP level reflects the risk of cardiac surgery in response to homeostatic derangement.
Cardiac Surgical Procedures↗
[Coarctation of the aorta with right aortic arch].
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Abnormalities, Multiple↗
[Study of postoperative hemodynamics and fluid balance after open heart surgeries in relation to the rectal and peripheral deep body temperature].
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Adolescent↗