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Biomedical subjects

F Molinari

Publications and source records attributed to F Molinari.

At least 37 records · Page 2Linked to original sources
PubMed1981

Reflux esophagitis and duodenogastric reflux.

The authors studied the endoscopic and histological characteristics of 65 asymptomatic subjects, of 14 patients with gastroesophageal acid reflux (AR), of 11 patients with bile gastroesophageal reflux (BR) and of 10 patients with acid-biliary gastroesophageal reflux (ABR). Endoscopic pictures corresponding to esophagitis were found in 5 controls, in 4 patients with AR, in 9 patients with BR and in 7 cases with ABR. Histological esophagitis has been demonstrated in 13 controls, 4 cases with AR, 6 cases of BR and 5 cases with ABR. Endoscopic findings were confirmed histologically in 20% of controls, 33% of AR, 55% of BR and 57% of ABR. Bile seems therefore to be the prevalent factor in determining the reflux esophagitis.

Adult↗
PubMed1981

Chronic gastritis and duodenogastric reflux.

The histological and histochemical patterns of fundic and antral mucosa were assessed in 36 patients with normal pyloric competence and in 28 patients with duodenogastric reflux (DGR), evidenced by Capper's test. There was a significant increase of antral gastritis with normal fundic mucosa in patients with DGR compared with controls. In contrast, patients with DGR show a fundic gastritis incidence similar to that in age-matched controls. The histochemical studies failed to reveal differences between the two groups with and without DGR. These data confirm previous experiences on the possible role of DGR in the pathogenesis of antral gastritis. However, there is no correlation between duodenogastric reflux and fundic gastritis.

Adult↗
PubMed1979

Parietal cell mass after short and long term cimetidine treatment of duodenal ulcer.

The parietal cell mass (PCM) was evaluated on endoscopically obtained biopsy specimens of fundus mucosa from 20 duodenal ulcer patients before and after cimetidine treatment. Patients were given cimetidine, 1 g/day, for 28 days. Six out of the 18 cases which healed after short-term therapy went on taking 400 mg/day of cimetidine for 9 months. The PCM was expressed by means of an index (PI) obtained by multiplying the mean cell number per mm of section surface by the mean parenchymal thickness. The analysis of the obtained data failed to demonstrate any significant difference between the PI observed before and after 28 days treatment with cimetidine, while after long term treatment for 9 months, a significant increase of the PI was achieved.

Adult↗
PubMed1978

Treatment of active duodenal ulcer with oral cimetidine: a multicenter controlled endoscopic trial.

A double-blind 4-week trial of cimetidine (1 g daily) versus placebo was conducted in 68 adult outpatients with active duodenal ulceration endoscopically confirmed. 3 of the patient admitted to the study (1 on cimetidine and 2 on placebo) did not complete the trial. After 4 weeks of treatment, 25 of 33 patients (76%) receiving cimetidine had healed their ulcers compared with 15 (47%) of 32 patients receiving placebo (p less than 0.02). Antacid consumption was also significantly decreased by cimetidine when compared with placebo. Tolerability of the drug was good.

Administration, Oral↗
PubMed1976

[Hemato-tissue eosinophilia in a case of ulcerative rectocolitis].

A case of ulcerous rectocolitis presenting a remarkable haematic and tissue eosinophilia, both rectal and gastric, is described. After therapy, the eosinphil complement decreased in the blood but not in the colic mucosa. It is suggested that eosinphilia is not a particular characteristic of ulcerous colitis, but the expression of an inidvidual reaction to an inflammatory stimulus.

Adult↗
PubMed1976

Gastric reflux measurements during duodenal infusion with saline, acid and fat.

Duodeno-gastric reflux measured in 18 patients without gastrointestinal complaints showed a wide variation of regurgitation rates. Duodeno-gastric reflux was significantly diminished during duodenal acidification. The effect was more intense and lasted longer after olive oil infused intraduodenally, leading practically to a closed pylorus.

Adult↗
PubMedDate not supplied

A multiphasic hollow fiber reactor for the whole-cell bioconversion of 2-methyl-1,3-propanediol to (r)-beta-hydroxyisobutyric acid.

This paper describes the bioconversion of 2-methyl-1,3-propanediol to (R)-beta-hydoxyisobutyric acid (HIBA) by Acetobacter ALEI in a hollow fiber membrane bioreaction system arrangement that allows the integration of three liquid phases: the aqueous bioconversion phase, the organic phase consisting of a solution of trioctyl phosphine oxide (TOPO) in isooctane, and the third phase consisting of a basic stripping solution that allows reextraction of HIBA from the organic phase. A comparison of HIBA mass transfer experiments was carried out in the membrane reactor with two and three phases for different pH and TOPO concentrations. The use of the three-phase arrangement allows the extraction of high quantities of HIBA from the aqueous medium (higher than 85%) independently of the pH, whereas in the two-phase system the percentage of HIBA extracted from the aqueous medium was lower, 42% in the best case, and strongly influenced by the pH. The percentage of the extractive agent TOPO in the organic phase influenced on the mass transfer rate in both bi- and triphasic arrangements. By simply integrating the re-extraction phase in the system it was possible to increase the extraction yield by 2-fold, reduce the amount of TOPO by 4-fold, and operate at the more favorable pH 4. A bioconversion experiment was done in these conditions (pH = 4, TOPO = 5%) to confirm the advantages of including the third stripping solution. Fed-batch operation of the triphasic membrane reactor was maintained for more than 20 h, reaching an HIBA concentration in the stripping solution of 29 g L(-)(1).

Acetobacter↗
PubMedDate not supplied

[Gastric stump carcinoma after resection for benign gastric or duodenal ulcer (author's transl)].

33 cases of cancer of the gastric stump after gastrectomy for peptic ulcer observed between 1963 and 1972 are reviewed. In 26 patients the average interval between operation and carcinoma detection was over 20 years. No cases of carcinoma occurred in less than 10 years. All patients came too late for surgery, since they had attributed their symptoms to the previous operation. The gradual increase in the gastric-cancer risk of operated patients with time suggests a continuous carcinogenic influence. Regurgitation of duodenal contents through the Billroth II anastomosis seems to be the most important cause of postoperative atrophic gastritis, which is now considered by many authors to be a condition predisposing to gastric cancer. Gastric resection patients should be regarded as a high gastric-cancer risk group. The periodic use of modern procedures for early gastric cancer detection in this group of patients is therefore justified.

Aged↗
PubMedDate not supplied

Lymph node imaging: from conventional radiology to diagnostic imaging.

From Herophilus, Aristotle in the 3rd century BC, Aselli, Pecquet, Mascagni to Jossifow and Rouviere the lymphatic system was investigated. Kinmonth and Wallace were the first to study it with lymphangiography. Mediastinal lymph nodes were poorly visualized in high contrast radiography before the seventies; subsequently with the high voltage technique, xerography and signs from mediastinal lines they were better identified. However these procedures were replaced by CT, with which even lymph nodes less than 0.5 cm in size, are recognized. The differentiation between normal and pathologic lymph nodes is based on dimensional, morphologic and densitometric criteria. CT is able to identify typical patterns of inflammatory, systemic and metastatic lymph nodes. On lymphography a great number of signs as gross and dense dotting, foaming, chipping and lacunae are identified, which allow the differentiation of inflammatory, systemic and metastatic patterns. On sonography some nodal characteristics are evidenced as the round shape, hypoechogenicity, absence of hyperechoic medullary line. CT has replaced lymphangiography in the study of abdominal lymph nodes.

Humans↗