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Biomedical subjects

F Matsubara

Publications and source records attributed to F Matsubara.

At least 217 records · Page 12Linked to original sources
PubMed1978

Congenital hepatic fibrosis. A case report with study of three dimensional reconstruction of serial sections of the liver.

A patient who developed pancytopenia and hepatosplenomegaly with portal hypertension is described. Liver wedge biopsy at the time of operation showed typical histology of congenital hepatic fibrosis. Renal surgical biopsy revealed tubular ectasia. A continuous anastomosing network of the biliary tree was observed by reconstruction of serial sections of the liver. Some parts of the network were dilated and no isolated bile ducts were present.

Adolescent↗
PubMed1977

Morphological study of the Paneth cell. Paneth cells in intestinal metaplasia of the stomach and duodenum of man.

The Peneth cells in intestinal metaplasia of stomach and the duodenum in human subjects were studied ultrastructurally, and the fine structures of these cells were compared. Paneth cells showed the ultrastructure of serozymogenic cells and secreted their secretory granules by merocrine process. The rod or tubular dense bodies were observed in the apical region of some Paneth cells. The structures may have some relation to the secretion of the secretory granules. The secretory granules with less dense layer in the periphery, which had never been described in the Paneth cell of man, were also observed. Morphologically intermediate cells between Paneth cell and goblet cell were found. Some of the Paneth cells might be phagocytized by undifferentiated crypt cells. The Paneth cells in intestinal metaplasia were fundamentally the same as those in duodenum at least in morphology. Difference between them was that Paneth cells with many phagolysosomes in the lower cytoplasm were observed more frequently in the duodenum than in intestinal metaplasia of the stomach. The physiological functions of the Paneth cell have been discussed.

Duodenal Diseases↗
PubMed1976

Occurrence of renovascular hypertension in two sisters.

Renovascular hypertension in two sisters, aged 22 and 20, respectively, has been described. Renal artery stenoses were observed unilaterally in the elder patient and bilaterally in the younger one. In both patients, the functional significance of unilateral stenosis of the renal artery was documented by the renal vein renin ratio between the affected side and the contralateral or less affected side. High blood pressure and elevated plasma renin activity have been normalized with a unilateral revascularization in the elder patient, and with the treatment of propranolol in the younger one. The histological examination of the stenotic renal artery in the elder patient showed a finding comparable to the perimedial fibroplasia in Harrison and McCormack's classification of idiopathic fibromuscular stenosis.

Adult↗
PubMed1975

Clinical value of the thyrotropin-releasing hormone stimulation test in predicting mild hypothyroid state in chronic thyroiditis.

In order to evaluate the clinical usefulness of the TRH stimulation test in predicting premyxedematous state in chronic thyroiditis, serum TSH response to the i. v. injection of TRH was determined in 58 patients with chronic thyroiditis proven by needle or open biopsy. TSH radioimmunoassay was done by a double antibody technique, and the degree and pattern of TSH response were assessed based on our criteria established by the results obtained from 9 normal controls. According to Woolner's classification, 35 cases were diagnosed as diffuse type. 19 cases as focal type and 4 cases as hyperplastic. The basal levels of TSH were above the normal range in 71.4% of diffuse thyroiditis, whereas 36.8% of the patients with focal thyroiditis had an abnormally high basal TSH level. Responses of serum TSH to TRH was exaggerated in 67.1% of all patients; 80.0% in diffuse type and 47.4% in focal type. Concerning TSH response curve, 15 patients were judged as "prolonged", and 8 patients as "delayed" response. No weak responder in the TRH test was found in patients with high basal TSH level, 91% of whom had an exaggerated response. Serum levels of thyroxine and triiodothyronine inversely correlated with basal, maximal TSH levels (p less than 0.01) and increment of TSH (delta TSH) after TRH injection (p less than 0.01). Thyroidal uptake of I131 also inversely correlated with basal TSH level (p less than 0.05) but not with maximal TSH and delta TSH. From the fact that an elevation of basal TSH level and its hyperresponsiveness to TRH administration develop in a much more exaggerated fashion compared to the changes in other parameters of thyroid function, it was concluded that TRH test provides a useful rationale for the early diagnosis of premyxedema in chronic thyroiditis.

Adult↗