A further case of granulomatous hypersensitivity angiitis (syndrome described by Churg and Strauss) is reported. Clinical, biological, and histological features (asthma, blood eosinophilia, necrotizing angiitis lesions, extravascular eosinophilic and granulomatous infiltrates) differentiate this affection from other necrotizing angiitis diseases, particularly from polyarteritis nodosa. Unusual features in this case were its favorable course, and the remission following combined corticoid and cyclophosphamide treatment. Diagnostic, clinical and histological criteria which distinguish Churg and Strauss's angiitis from other necrotizing angiitis affections are described, and current pathogenic hypotheses discussed.

Adult↗

PubMedDate not supplied

A simple photometric microassay for the quantitative evaluation of macrophage-mediated cytotoxicity on adherent cancer cells.

A new in vitro microassay was devised for the quantitation of macrophage-mediated cytotoxicity on cancer cells. After 72 h of culture with macrophages, the residual adherent target cells were stained with methylene blue. The cell-bound dye was then eluted and measured in a photometer. This assay is simple, quickly performed and gives reproducible results in good correlation with direct counting of the residual cells. It allows a quantitative evaluation of the whole toxic effect (cytostasis and cytolysis) of activated macrophages on adherent tumour cells.

Animals↗

PubMedDate not supplied

Expressed sequence tags of randomly selected cDNA clones from Eucalyptus globulus-Pisolithus tinctorius ectomycorrhiza.

Random sequencing of cDNA clones from Eucalyptus globulus-Pisolithus tinctorius ectomycorrhizal tissues was carried out to generate expressed sequence tags (ESTs). Database comparisons revealed that 42% of the cDNAs corresponded to previously sequenced genes. These ESTs represent efficient molecular markers to analyze changes in gene expression during the formation of the ectomycorrhizal symbiosis.

Animals↗

PubMedDate not supplied

Volunteering for disaster nursing.

Explore the source record for details and available documents.

Disaster Planning↗

PubMedDate not supplied

[Specific and non specific immunitary defences against intestinal cancers. Bases, possibilities and limits of immunotherapy (author's transl)].

Explore the source record for details and available documents.

Animals↗

PubMedDate not supplied

mdr 1 gene-expression and villin synthesis in a colon cancer cell line differentiated by sodium butyrate.

Sodium butyrate (NaBu) but not dimethylsulfoxide (DMSO) induced the synthesis of villin, a protein of the brush border microvilli cytoskeleton, in a rat colon cancer cell line. Neither NaBu nor DMSO altered mdr 1-mRNA expression or multidrug resistance (MDR)--associated cellular transport of doxorubicin. These results show that mdr 1 gene expression and activity are independent of other brush border proteins induced by differentiating agents at the apical pole of the epithelial cell.

Animals↗