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Biomedical subjects

F Martin

Publications and source records attributed to F Martin.

At least 523 records · Page 29Linked to original sources
PubMed1981

Cancer of the esophagus. An incidence study of Côte d'Or (Burgundy).

The registry of digestive cancer set up for the French department of Côte d'Or (455, 727) enables a morbidity study about esophageal cancer to be made among residents. The crude animal incidence rate was 16.7/100,000 for males and 1.2/100,000 for females. Corresponding age-standardized rates were 13.2 and 0.5. The sex ratio is extremely high. Among other cancer registries Côte d'Or is in the intermediate range for males, and in the low range for females. 40% of tumors were in the middle third, 37% in the lower third, and 23% in the upper third. Most cancers were squamous cell carcinomas (94%). The risk of an associated aerodigestive tract tumor is important (16%). 10% of patients were operated upon for cure, 53% had radiotherapy. The 1 year crude survival rate was 25%.

Adenocarcinoma↗
PubMed1981

[Endolaryngeal surgery using highly concentrated human fibrinogen as tissue adhesive. Further trials with fibrin glue].

The use of an activated human fibrinogen concentrate in endolaryngeal surgery has been performed in 31 cases without the conventional suturing technique. Among the satisfactory results of fibrin gluing in endolaryngeal regions are optimum healing tendency due to haemostasis, lack of tissue irritation and toxicity. Persistence and highly adhesive properties were studied in experimental investigations in the dog following motoric stress of clot-sutured vocal cords.

Adult↗
PubMed1981

[Factors of early prognosis in medically treated haemorrhages of upper gastrointestinal tract in cirrhotic patients. Statistical study (author's transl)].

In order to define immediate criteria of prognosis for patients with cirrhosis, hospitalized in emergency for upper gastrointestinal tract haemorrhage, 164 cases of haemorrhages medically treated were reviewed. A prognostic study of each variant points to the clinical endoscopic and biological data connected with death. That study illustrates the prognostic value of traditional data. Patients who died within the first 30 days had a significantly higher incidence of hepatic encephalopathy, hematemesis, ascites, low blood pressure, bleeding oesophageal varices during endoscopy,. hypoprothrombinemia, hyperbilirubinemia. Those who survived had a significantly higher incidence of aspirin intake, numerous haemorrhages, good state of health, non bleeding peptic ulcer. Several series of multivariant analysis : multiple regression and linear discrimination, differing from one another in variates were done. They have allowed identification of 11 variables used in establishing a prognostic index. In the series, it gives an 87% probability of correct differentiation. Such an index allows an objective estimate of the value and limits of a group of patients in which the efficiency of other treatments could be tested in controlled trials.

Adult↗
PubMed1981

A cooperative study on the detection of colorectal cancer and polyps in France.

Systematic investigations testing for the presence of polyps and cancers of the large bowel were conducted in a population of 1,369 inpatients and outpatients, aged 45-70 years, in eight university departments of gastroenterology or abdominal surgery (Toulouse, Dijon, Paris, Marseille, and Strasbourg). Double-contrast barium enema and proctosigmoidoscopy examinations were carried out in all cases, whereas total coloscopy was performed only in the case of detected tumors. A questionnaire including 233 parameters (age, sex, family, and personal history and symptoms) was completed for each patient. A total of 414 lesions were detected in 252 patients, including 245 adenomatous or villous polyps, 8 transformed polyps, and 30 carcinomas; 3 of 4 lesions were located in the rectum or sigmoid. Cancer or adenomatous or villous polyps were found in 13% of the patients. The prevalence of these lesions in the population studied was increased in patients with rectorrhagia (19%) or with a personal history of surgery for colorectal cancer or polyp (23%). In the patients without rectorrhagia or a history of intestinal tumor, the incidence was 9.7%. It was significantly increased in males and patients more than 50 year old. The efficacy of proctosigmoidoscopy and double-contrast barium enema was compared in 909 patients. Sensitivity and specificity were, respectively, 35% and 99% for endoscopy, 96% and 94% for radiology.

Aged↗
PubMed1980

The stimulation of the initiation of DNA synthesis by fibroblast growth factor in Swiss 3T3 cells: interactions with hormones during the pre-replicative phase.

Fibroblast Growth Factor (FGF) stimulates quiescent Swiss 3T3 cells to initiate DNA synthesis and divide. Cells begin to enter the S-phase after a lag of 13--15 hr, and the rate of initiation of DNA synthesis in the population can be quantified by a first order rate constant, k. A subsaturating concentration of FGF may establish the lag phase, while the value of k is dependent on the FGF concentration present during the second half of the lag phase. Insulin and hydrocortisone enhance the effect of FGF by increasing k without changing the lag phase, and they can act when added at any time after FGF. Prostaglandin E1 (PGE1) causes a decrease in k and a lengthening of the lag phase, and acts only when added during the first 8 hr. None of these agents stimulate DNA synthesis in the absence of FGF.

Animals↗
PubMed1980

Incidence of digestive tract cancers in a well defined population in France.

A systematic registration of mortality and morbidity from digestive tract cancers was started in January 1976 in the French department of Cote d'Or (population 455,727). In the course of 3 years 1356 newly diagnosed cases were recorded. In males cancer of the rectum is the most common digestive tract cancer, coming before cancer of the stomach and cancer of the colon. In females cancer of the colon prevails over cancer of the rectum and cancer of the stomach. The survey allows comparison with the incidence rate of digestive cancers in other countries. Results of treatment underline the lateness of diagnosis.

Colonic Neoplasms↗
PubMed1980

[Effect of 15 antineoplastic drugs on colon carcinoma growing in vitro: a screening assay for cytotoxicity (author's transl)].

The cytotoxic effects of 15 drugs used in clinical oncology have been studied on rat colon cancer cells growing in vitro. A 50 per cent cytotoxic activity was obtained with molar concentration from 1.3 10(-8) to more than 4.10(-2), according to the drug. This cheap and quick assay could be useful for screening new drugs or new drug associations to be selected for clinical trials.

Animals↗
PubMed1979

[An incidence study of digestive cancers in a well defined population. Results of two years registration in the departement of Côte d'Or (author's transl)].

A systematic registration of mortality and morbidity from digestive cancers was started in January 1976 in the French department of COTE-D'Or (population 455,727). In the course of two years 913 new cases of digestive cancers were recorded. Nearly half of these cancers were colorectal cancers. The survey gives informations on histology, stage of the disease and survival. The morbidity survey allows comparison with the incidence rate of digestive cancers in other countries.

Adult↗