Tamm-Horsfall Protein (THP) is a 95 kD glycoprotein which is secreted in the thick ascending loop of Henle (TALH) of the kidney. After renal tubular damage the secretion of THP is reduced. In diabetes mellitus (DM), TALH has not been studied. To differentiate between glomerular (albumin), proximal tubular microglobulinuria (alpha 1-microglobulin), and TALH function (THP), we investigated 65 patients 4-61 years of age. In well-controlled DM, mean hemoglobin A1 equalled 7.4% and proximal tubular parameters indicated reversible damage early after onset. THP excretion (per 24 hrs or per day) was significantly elevated in DM duration of greater than ten years, suggesting enhanced TALH ion transport (glomerular hyperfiltration). THP secretion decreased in DM duration of greater than 15 years despite normal albumin excretion. Thus, renal THP excretion indicates early medullary dysfunction (TALH) in DM type I.

Adolescent↗

PubMedDate not supplied

[Nutritional iodine status of healthy infants in Germany].

In 78 healthy term babies from Düsseldorf and surroundings spontaneous urine samples were collected on day 108 to day 144 of life and analyzed for the content of iodine and creatinine. 26 babies were breast fed. 23 babies received an iodized hypoallergenic formula and 26 babies different commercial formulas only partly iodized. From 4 parameters to estimate iodine supply of the babies (urinary iodine concentration microgram/dl, iodine/creatinine ratio microgram/g; estimated daily iodine excretion microgram/d, estimated daily iodine excretion corrected for body surface area microgram/dl 1.73 m2) estimated daily iodine excretion was the most useful parameter. Breast fed babies showed a significantly lower estimated daily iodine excretion (median 32 microgram/d) than babies fed the hypoallergenic (52 microgram/d) or a commercial formula (54 micrograms/d). In Germany with an insufficient iodine supply of pregnant and lactating mothers breast fed infants run a risk for an insufficient iodine supply. Furthermore, supplementation of infant formulas with iodine started in 1990/1991 proved to be a sufficient measure to correct iodine deficiency.

Breast Feeding↗

PubMedDate not supplied

[Administration of creatine and creatinine with breast milk and infant milk preparations].

Creatine and creatinine intake can cause increased urinary creatinine excretion. To estimate the contribution of diet to creatinine excretion in infants, creatine and creatinine were determined in human milk, pasteurized cow's milk and formulas for preterm and term infants. Soy-based formulas did not contain creatine and creatinine. Average concentrations in human milk (creatine 77 [60-100] mumol/l, creatinine 52 [41-65] mumol/l) were markedly lower than in pasteurized cow's milk which contained 598 (476-640) mumol/l creatine and 105 (79-122) mumol/l creatinine. Creatine and creatinine concentrations differed widely in formulas for both preterm and term infants, from 155-559 and 33-174 mumol/l, respectively. The influence of ingested creatine on creatinine excretion should theoretically be negligible. On the other hand, based on known absorption data, creatinine from the diet should increase creatinine excretion in a 3-month-old infant up to an amount in the range of 5.3-28.4% of the endogenous production. Therefore creatinine ingestion should be taken into account when interpreting creatinine excretion in infants.

Creatine↗

PubMedDate not supplied

[Scheduled urine collection using disposable diapers with an acoustic signal emitter].

Usually, urine is collected from infants by means of a urine bag. This procedure has some disadvantages, as it can cause discomfort and may even be painful for the child if repeated application of the bags is necessary. Correct placement is difficult for parents or other untrained people and bag displacement is common especially in older mobile children. Urine collection with disposable diapers followed by urine extraction for analysis might be a simple alternative procedure especially for field studies. Urine output is measured by weighing the diapers. A moisture sensor with a sound signal indicates the moment of urination. Stool contaminated diapers must not be excluded from urine collection, if the stool is quickly removed after defecation using diaper liners. Wet diapers are sealed in plastic bags and may be stored at -20 degrees C until extraction. With a hydraulic press urine is extracted from the diapers for measuring concentrations of urinary constituents. After extracting urine after 1 hour and 10 hours contact time only the pH falls significantly. Concentrations of the other constituents tested (creatinine, urea, phosphorus, calcium, sodium, potassium, magnesium, chloride) and total osmolality are not effected. After freezing the wet diapers for storage osmolality and the concentration of creatinine tend to be slightly lower. For clinical practice these effects can be neglected. However, they must be considered using this urine collection method in research.(ABSTRACT TRUNCATED AT 250 WORDS)

Disposable Equipment↗

PubMedDate not supplied

[Treatment and prognosis of segmental renal hypoplasia].

Among 140 children with vesicorenal reflux 14 patients were found to be suffering from renal insufficiency. Seven of these patients had histologically proven bilateral segmental renal hypoplasia. Thanks to early commencement and sustainment of antihypertensive therapy, the prognosis of the condition was decisively improved. It does not appear to be worse than in other forms of reflux nephropathy at the renal insufficiency stage. Clinical courses in which there is no deterioration in renal function for more than 10 years are not uncommon. It is also possible to perform an anti-reflux plasty at the renal insufficiency stage. It is thus possible to permanently eliminate feverish infections of the urinary tract.

Adolescent↗

PubMedDate not supplied

[Acid-base regulation in premature babies and infants fed on human milk and cow milk nutrients].

Babies receiving formulas based on cow's milk show a higher renal net acid excretion than babies receiving human milk. Nutrition producing a high renal net acid excretion may cause clinical problems. Formula based on cow's milk should be modified in order to decrease the acid load. Renal net acid excretion may be estimated from the analytical data of a diet. Possibilities to decrease renal acid excretion in infant feeding are discussed.

Acid-Base Equilibrium↗