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Biomedical subjects

F Magora

Publications and source records attributed to F Magora.

At least 73 records · Page 4Linked to original sources
PubMed1980

Effect of sodium bicarbonate on the kinetics of bupivacaine in i.v. regional anaesthesia in dogs.

Changes in pH studied in vitro affected considerably the distribution of bupivacaine between the erythrocyte and incubation medium: in an acidic medium, the uptake of bupivacaine by erythrocytes was decreased. The acidosis induced in vivo in dogs' limbs during i.v. regional anaesthesia (IVRA) with bupivacaine was corrected by injecting sodium bicarbonate into the occluded limb. The concentration of bupivacaine in the cephalic vein was measured in dogs under. IVRA. After removal of the tourniquet, the drug concentration-time relationship showed a biexponential pattern of decline. Injection of sodium bicarbonate into the limb 10 min before the release of the tourniquet suppressed the rate at which the concentration of bupivacaine decreased during the second phase. This slower rate of drug release from the tissues may prolong residual analgesia.

Anesthesia, Conduction↗
PubMed1980

Motor nerve conduction in intravenous regional anaesthesia with bupivacaine hydrochloride.

Motor nerve conduction (MNC) from proximal and distal points of the median and ulnar nerve was examined in 14 patients receiving a total of 29 i.v. regional anaesthetics (IRA) with bupivacaine hydrochloride in doses ranging from 100 to 300 mg. Conduction was tested during and following vascular obstruction, until MNC returned to pre-IRA value. After 20 min of obstruction, MNC was unobtainable in most patients, an effect which was dose-related. The action of bupivacaine on MNC persisted for up to 3 h after cuff release, depending on the dose, and paralleled voluntary movements. MNC block began at the proximal point of both nerves, the median nerve being affected earlier. Based on the clinical and electrical findings, bupivacaine 200 mg proved to be optimum dose for producing safe and prolonged IRA.

Anesthesia, Conduction↗
PubMed1980

Prolonged effect of bupivacaine hydrochloride after cuff release in i.v. regional anaesthesia.

Bupivacaine hydrochloride 0.25% and 0.50% solutions, were administered 115 times by the i.v. regional route to 64 surgical patients and in 38 subjects suffering from pain syndromes. The clinical effects were limb numbness up to 20 h following cuff release, while analgesia and weakness of the limb muscles were evident 5 h after the tourniquet. Clinical and electrophysiological findings revealed a dose relationship of the effects. Toxic signs were noted in three patients in whom the cuff was released in a one-step fashion. In 11 patients, mean arterial plasma concentrations of bupivacaine reached 3.7 micrograms ml-1 after administration of 0.5% bupivacaine 40 ml, 5 min after final cuff release, and decreased gradually thereafter. In selected conditions which do not require a bloodless field and in certain intractable pain states, i.v. regional anaesthesia with high-dose bupivacaine (200 mg of 0.5% solution) may be a simple and effective technique.

Adult↗
PubMed1980

Observations on extradural morphine analgesia in various pain conditions.

We report the extradural administration of low-dose morphine in 10 ml of 10% dextrose (2-3 mg) to 98 adult patients with various types of acute and chronic pain. Extradural morphine injections were given either via a Tuohy needle (single or repeat injection) or via an extradural catheter. Pain relief was evaluated by subjective scoring and by the subsequent need for systemic analgesics. In 56% of patients, pain relief was considered good or excellent, in 24% it was fair, and in 20%, poor. The best results were after surgery and trauma and in patients with advanced peripheral vascular disease. The analgesia of each dose of extradural morphine lasted for 8 h (mean range 4-36 h). There was no motor, sensory or sympathetic blockade and no respiratory or haemodynamic complications. Dizziness and vomiting occurred in two patients, and urinary retention for about 12 h in three.

Adult↗
PubMed1980

Intravenous regional guanethidine treatment in peripheral vascular disease.

Twenty-eight patients with spastic and obstructive vascular disease were treated with intravenous regional guanethidine (IRG). The drug was injected into the affected hand or foot in doses of 10 or 20 mg, respectively. Temperature and strain-gauge plethysmography curves of the extremity were recorded before treatment, and three to four times during the subsequent 10 days. The effects of IRG, as observed by clinical laboratory examinations, were good in 8 of 12 patients. But in patients suffering from Bürger's disease or from major vessel obstructive disease, the results were not as good. However, in most patients IRG proved beneficial in relieving pain, an effect which sometimes outlasted objective improvements. IRG treatment is a simple and safe method for prolonged chemical sympathectomy.

Adult↗
PubMed1980

[The pain clinic].

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Antipsychotic Agents↗
PubMed1979

Epidural morphine in treatment of pain.

Epidural injections of a 2 mg morphine were given to 10 patients with severe acute or chronic pain. All cases had considerable amelioration of pain, which commenced within 2-3 min, reached a peak in 10-15 min, and was effective for 6-24 h. It is suggested that the morphine reached the subarachnoid space and produced its effect by direct action on the specific opiate receptors in the substantia gelatinosa of the posterior-horn cells of the spinal cord.

Acute Disease↗
PubMed1978

Intermittent mandatory ventilation during anaesthesia using the Manley Servovent ventilator.

The lungs of 25 patients were ventilated with intermittent mandatory ventilation (IMV) during anaesthesia using the Manley Servovent Model MS. This ventilatory mode is especially suitable for prolonged operations in which there is no need for muscle relaxation. While incorporating the advantages of spontaneous and mechanical ventilation, it is superior to both in selected cases. The Manley Servovent Model MS ventilator is capable of delivering IMV without modification, using a single source of gas.

Adolescent↗
PubMed1978

Treatment of pain by transcutaneous electrical stimulation.

Two hundred and ninety-two patients suffering from a wide range of pain syndromes were treated with transcutaneous electrical stimulation (TES). Electrical stimulation of the painful area was administered on the skin by externally applied electrodes, attached to a portable battery-operated apparatus. The results, determined according to a subjective scoring system, were good in 50.7%, moderate in 24.3% and poor in 25% of the patients. TES is a non-invasive technique, has no side effects and may easily be self-administered. It is concluded that it should be tried in pain syndromes for which no specific therapy is available.

Adolescent↗