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Biomedical subjects

F Magora

Publications and source records attributed to F Magora.

At least 55 records · Page 3Linked to original sources
PubMed1986

The action of intrathecal morphine and methadone on the lower urinary tract in the dog.

The effects of intrathecally administered morphine and methadone on lower urinary tract dynamics were investigated by cystometrograms and urethral pressure profiles in 16 anesthetized dogs. The examinations were performed before and 30, 60 and 90 minutes following intrathecal injection of 0.03 mg./kg. morphine or methadone. Intrathecal normal saline was used for control studies. Significant relaxation of the detrusor was noted after intrathecal morphine as expressed by a decrease in mean intravesical pressure (p less than 0.05) and by a rise in the calculated detrusor compliance. These effects were reversed by intravenously injected naloxone. As opposed to morphine, methadone caused an increase in detrusor tone. No appreciable effects were observed on the urethra after intrathecal morphine or methadone. Neither intravenous injection of the opiates nor intrathecal administration of saline caused alterations in bladder tone. The result may imply a spinal, albeit opposing, effect of the two opiates on bladder dynamics.

Animals↗
PubMed1986

The propriety of narcotic usage in hospitalized patients.

The propriety of narcotic usage at the Hadassah Hospital has been studied in 35 cancer patients and 70 post-operative patients. Eighty-three per cent of the cancer patients and 66% of the surgical patients remained in moderate to severe distress in spite of the analgesic therapy. Insomnia and anxiety, plus depression in the cancer patients, were the major results of uncontrolled pain. The inadequacy of the treatment was attributed to the incorrect selection of medication, usage "as needed' policy and smaller daily doses than advocated. This resulted mainly because of exaggeration of the risk of tolerance and addiction by both patients and personnel.

Drug Utilization↗
PubMed1985

[Initial studies on the intraoperative use of spinally administered somatostatin].

7 cases are reported demonstrating that intrathecal or epidural administration of somatostatin intraoperatively reduced the requirement for other anaesthetics. Somatostatin acts as a potent analgesic, which does not impair circulatory parameters and which possesses no centrally depressing effect. Spinal administration of somatostatin could therefore gain importance in high-risk category patients with normal metabolism.

Adult↗
PubMed1985

Trigeminal glycerol rhizolysis in the treatment of tic douloureux.

Eleven patients suffering from trigeminal neuralgia were treated by percutaneous glycerol trigeminal rhizolysis after visualization of the trigeminal cistern with metrizamide. In 10 of 11 cases treatment was successful and the pain disappeared. The technique of the treatment is described. This form of treatment is recommended as a successful and simple method, especially in the elderly population suffering from trigeminal neuralgia.

Glycerol↗
PubMed1984

The effect of phenoxybenzamine on postoperative urinary complications during extradural morphine analgesia.

One hundred and fifty patients, post-Caesarean section, were investigated to evaluate the effect of epidural morphine analgesia and that of phenoxybenzamine on the frequency and extent of urinary complications. Forty patients (group A) underwent Caesarian section under general anaesthesia, while 110 patients received epidural anaesthesia. Of the latter patients, 40 received postoperative mild analgesics (group B) whilst in another 40, postoperative continuous epidural morphine was administered (group C). Thirty patients who received postoperative epidural morphine, also received oral phenoxybenzamine 10 mg, 24 and 1 hr prior to, and 8 and 16 hr following surgery (group D). The volume of urine of the first two postoperative voidings, the time delay to first micturition, difficulty in micturition and urinary retention necessitating bladder catheterization were studied. The mean volumes of the first two postoperative voidings were markedly reduced in group C (219 and 218 ml, respectively) as compared with group A (383 and 453 ml) and with group B (319 and 414 ml, respectively). In group D, these mean volumes were significantly larger at 478 ml (p less than 0.01) and 417 ml (p less than 0.01) as compared with those of group C. The mean time to the first postoperative voiding was 582 min in group C, which was significantly longer than that in group A (339 min) or in group B (448 min). In the patients treated with phenoxybenzamine, the time to the first postoperative voiding was significantly less at 322 min (p less than 0.01). The need for bladder catheterization was also increased in group B compared with group A, while in group C this increase was marked compared with both groups A and B. It was significantly less frequent in those receiving phenoxybenzamine. Phenoxybenzamine is recommended in the prevention of postoperative urinary complications associated with epidural anaesthesia and epidural morphine analgesia.

Adult↗
PubMed1982

Electrical stimulation in the treatment of the painful hand.

Fifty patients with painful hands due to inflammation, trauma, or surgery were treated by means of a Neurogar nerve stimulator. In 82% of the cases the results were satisfactory. Early physiotherapy was possible, and yielded best recovery and healing.

Amputation, Traumatic↗
PubMed1981

Postoperative analgesia by percutaneous electrical stimulation in gynecology and obstetrics.

Percutaneous electrical stimulation (PES) for relief of acute postoperative pain was applied in 10 patients after cesarean section and in 20 women who had undergone various gynecological operations. Thirty other women, subjected to identical surgical interventions, served as controls. In the latter group, the electrodes were attached to a nonfunctioning apparatus. In all patients, including the controls, the two electrodes were introduced intradermally, one on each side of the incision. Implantation was carried out at the end of the surgical procedure while the patient was still anesthetized, and stimulation was commenced immediately. The electrical stimulation was applied continuously for 1 to 3 postoperative days. The generation of pulses was perceived by the patients as a tingling sensation. Complete pain relief was obtained in 40% of the patients treated with PES, whilst in 27% the pain was markedly diminished. Postoperative analgesic medication in this group was reduced by 50-80% as compared to the analgesic requirements in the control group. Other beneficial effects observed in the treated patients included early ambulation, early peristalsis, postpartum uterine contractions and absence of respiratory complications.

Adnexa Uteri↗
PubMed1981

Epidural morphine for the control of pain after cesarean section.

Epidural morphine was evaluated for the control of postoperative pain after cesarean section (CS). Sixty-five patients undergoing elective CS with epidural bupivacaine were studied. Of these, 40 were given a single dose of 4 mg of morphine through an epidural catheter on termination of surgery. The remaining 25 patients received no postoperative epidural medication. In all cases, the catheters were withdrawn before the patients left the operating theater and 15 mg doses of papaveretum (OMNOPON) ordered as required for pain relief. The ward staff was unaware of the study. The time between the termination of surgery and the first administration of postoperative narcotic was noted, as was the total dose, for 48 h. The epidural morphine was associated with a prolonged period of postoperative analgesia and a greatly reduced total papaveretum requirement for the 48 h (30.9 mg for the study group in contrast to 67.6 mg for the controls). The difference between the two groups was significant (P less than 0.001). We concluded that epidural morphine is an efficient method for the control of postoperative pain following CS, a single dose of 4 mg providing relief from pain for 8 to 12 h and sometimes longer.

Cesarean Section↗
PubMed1980

Epidural morphine analgesia in second-trimester induced abortion.

Epidural administration of 2 mg of morphine to 16 patients who were undergoing induced abortion in the second trimester of pregnancy abolished labor pains in 10 of them within 10 to 20 minutes after treatment was begun. The pain did not recur until the abortion process started, sometimes hours later. In one patient, the relief of pain was achieved with an additional top up dose of 1 mg 15 minutes later. In the other five patients in whom the morphine had no appreciable effect, the addition of 4 ml of 0.5% bupivacaine hydrochloride, also injected epidurally, successfuly abolished pain. Because of the beneficial and prolonged action of morphine, as well as the lack of side effects, continuous epidural analgesia with low doses of it--supplemented, if necessary, with small quantities of bupivacaine--is effective for treatment of labor pains in induced abortion in the second trimester of pregnancy. The involvement of the anesthetist from the very beginning of the induction procedure is highly recommended.

Abortion, Induced↗
PubMed1980

Relief of pain by subcutaneous electrical stimulation after ocular surgery.

Electrical stimulation in the treatment of postoperative ophthalmologic pain was applied in 25 patients. In 21, stimulation was applied by means of subcutaneously implanted wires and in four patients the therapy was administered by externally placed electrodes. The subcutaneous electrodes were introduced near the supraorbital and infraorbital nerves at the end of the surgical procedures, and stimulation was immediately begun. Duration of treatment varied between one and three days. The nerve stimulator is a portable, battery-operated apparatus. The implanted electrodes avoid skin resistance and are extremely stable, thus affording uniform current intensity that does not change during sudden movements. As a result, the stimuli are perceived as a pleasant sensation. Complete pain relief was attained in nine patients, and in 13 patients the pain was diminished. The therapy is appropriate and effective in postoperative ocular pain, because the pain is restricted to a limited area, innervated by superficial nerves that are easily accessible to electrical stimulation.

Adolescent↗