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Biomedical subjects

F Müller

Publications and source records attributed to F Müller.

At least 505 records · Page 28Linked to original sources
PubMed1978

[Influence of different components of stored blood on the infectivity of Treponema pallidum (Nichols Strain) (author's transl)].

A factor with killing effect at 35 degrees C on Treponema pallidum is shown to be in normal human serum. The activity of this factor is increased by the stabiliser of stored blood.--In the presence of the stabiliser T. pallidum loses its infectivity in human serum at 4 degrees C within 10 hours. The mechanism of the reaction is explained.--Finally it is discussed whether these observations may be helpful in the prevention of transfusion syphilis.

Animals↗
PubMed1978

[Anterior falcate artery in the adult].

The anterior falcate artery (arteria falcea anterior) represents the continuation of the anterior ethmoidal artery. In the adult, it has been described previously only in its rostral portion, which supplies the falx cerebri. In the present study, however, it is shown that there exists a continuation which runs in the parietal dura of the superior sagittal sinus and which unites with the frontal branch of the middle meningeal artery at the border between the frontal and parietal bones. In addition, the anterior falcate artery, by means of arterioarterial connections, is associated with the nearby branches of the frontal ramus that supply the frontal dura. The anterior falcate artery, mostly paired, is furnished with cross-connections. Venae comitantes are absent from the parallel-running main branches. In occlusion of the ophthalmic artery, the anterior falcate artery, due to its connections with the middle meningeal artery, may be significant in the establishment of a collateral circulation to the orbit.

Adult↗
PubMed1977

[Therapy of obesity--effectiveness of calorie-reducing diets with various basic nutritional relations].

Within the research project nutrition and performance on altogether 80 test persons during a three weeks' test period the problem was examined, whether the relations of the basal nutrients have an influence on the effectiveness of a diet with an only moderate reduction of calories. The relations of the nutrients were tested in four variants. The daily caloric intake orients at the optimum weight of the test person: 30 kcal/kg optimum weight a day. It was shown that the so-called optimum weight caloric diet led to a sufficient continuous decrease of weight without disturbances of the general state of health. The variation of the relations of the basal nutrients had no decisive influence on the effectiveness.

Adult↗
PubMed1977

The development of the anterior falcate and lacrimal arteries in the human.

Certain arteries of the head were studied in injected human fetuses from 143 to 290 mm C.-R., as well as in the orang-utan and gorilla, and in microscopical sections from 29 to 162 mm C.-R., as well as in an adult. It was found that, during human ontogenesis, an anterior falcate artery supplies the dura mater of the medial part of the frontal bone. It appears at 40 mm and reaches its full development by 115 mm. Normally it becomes reduced and is transformed into the anterior meningeal artery postnatally. It communicates with the meningeal branches of the lacrimal artery. Under pathological conditions that affect the dura mater, the falcate artery may appear postnatally in angiograms.

Animals↗
PubMed1977

[Serodiagnosis of syphilis from the viewpoint of the immunologist].

A review of the immunology of the serological diagnosis of syphilis is given and modern methods for the demonstration of treponema-specific antibodies are shown. The possible combinations of test results and interpretations of these are discussed. The importance of the demonstration of treponema-specific IgM-antibodies not only for diagnosis but also for basis of treatment is finally pointed out.

Adult↗
PubMed1977

[Technical advances in demonstration of treponema-specific 19S-IgM antibodies in patients with latent or late-latent syphilis (author's transl)].

In patients with latent or late-latent syphilis as well as neurosyphilis the demonstration of treponema-specific 19S-IgM antibodies is not regularly possible. In this publication it is shown that high IgG antibodies are the reason for a competitive IgM inhibition in the indirect immunofluorescence tests. It is demonstrated that in the above mentioned states of the infection the IgM-FTA-19S test seemed to be the method of choice to realize the existence of 19S-IgM antibodies. In sera with competitive inhibited IgM it is possible to calculate the IgM antibody activity with the aid of the socalled F factor.

Antibodies, Bacterial↗
PubMed1977

[On the pharmacokinetics of phenazone in man (author's transl)].

Studies were carried out on the pharmacokinetic behaviour of 5-oxo-2,3-dimethyl-1-phenyl-3-pyrazoline (phenazone) by means of intraindividual comparison following oral and rectal administration in man. A one-compartment model served to describe the course of blood levels, in which the twin peaks of following rectal administration are quite remarkable. The influence of variation in the pharmaceutical dosage form on the pharmacokinetic behaviour patterns of phenazone were studied and intraindividual differences not inconsiderable are obvious.

Administration, Oral↗
PubMed1977

[Quantitative relationship between the monosaccharide induced change in ion transport and the monosaccharide accumulation in the rat jejunum].

1. In the rat's jejunum, the changes induced by Na+-dependently transported monosaccharides (10 mM) of the unidirectional Na+- and K+-influx across the microvilli membrane were studied under varying metabolic conditions. 2. The monosaccharide induced change of Na+- and K+-influx is a function of the ion gradients active across the microvilli membrane. 3. In the in vitro preparation during the process of energy-dependent accumulation the monosaccharide induced change of permeability in the microvilli membrane decreases the K+ concentration, while the Na+ concentration increases. 4. The monosaccharide concentration in the tissue reaches a final value which is proportional to the change of Na+- and K+-influx and to the change in ion concentrations, and which is retained even upon compensation of the gradient and at low intracellular K+ concentrations. 5. The correlation between the breakdown of the ion gradient and the rise of monosaccharide accumulation is explained by the monosaccharide induced restriction of the active ion transport and the ensuing change of energy dissipation in favour of the monosaccharide transport. The (Na+ + K+)-ATPase in the microvilli membrane is discussed as being transmitter of the energy from the ion gradients.

Animals↗
PubMed1976

Studies on the binding of FMN by apoflavodoxin from Peptostreptococcus elsdenii, pH and NaCl concentration dependence.

1. The pH and ionic strength dependence of the interaction of FMN with apoflavodoxin has been studied by fluorometry in the pH region 2-5, at 22 degrees C. 2. The rate constant of dissociation and the dissociation constant were experimentally determined; the rate constants of association were claculated at a given pH value. These constants depend on the ionic strength. The plots of these constants against the square root of the ionic strength are straight. 3. Our data have been interpreted in terms of the Brönsted theory, which relates chemical reaction rates to ionic strength. The data indicate that the apoenzyme reaches its maximum net positive charge at pH 2.0-2.6. The calculated net charge in this pH region is between 11 and 12 and is in agreement with the theoretical value of 12 as deduced from the primary structure of the protein. The isoelectric point of the holoenzyme is about 4. 4. The rate constant of association extrapolated to zero ionic strength is 3.2-10(5)M-1-s-1 and is pH-independent. 5. The rate constant of dissociation and the dissociation constant extrapolated to zero ionic strength depend on the pH. The results are explained by assuming that there are two protein ionizations with a pK value of 3.4; these ionizing groups are possibly close to the FMN binding site.

Apoproteins↗