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Biomedical subjects

F M Hall

Publications and source records attributed to F M Hall.

At least 181 records · Page 10Linked to original sources

The reprint game.

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Costs and Cost Analysis↗

A study of leucocyte labelling efficiencies obtained with 111In-oxine.

The range of leucocyte labelling efficiencies with 111In-oxine for a group of patients extended significantly (P = 0.05) below that obtained for a series of labellings of the same normal blood from a volunteer. A retrospective analysis was made of the results in the two groups to identify the cause of this difference in range. The labelling efficiency for patients did not vary with the volume of 111In-oxine, and was independent of the whole blood leucocyte concentration. The difference between the average labelling efficiencies obtained for a group of patients and the normal series labelled by the same operator was more significant than the difference in average labelling efficiencies obtained by different operators. It was concluded that biological variation in patients' blood, rather than operator technique, must have been a more important cause to the difference in the labelling efficiency range between patients and normal. It was also concluded that variations of contaminant platelet-bound activity and of plasma viscosity were greater in the patient group than the normal series, and contributed to this difference in labelling efficiency range.

Humans↗

Breast-milk radioactivity after a Tc-99m DTPA aerosol/Tc-99m MAA lung study.

Measurements were made of the concentration of Tc-99m activity in samples of breast milk following an administration of Tc-99m DTPA aerosol for a lung ventilation image and one of Tc-99m MAA for lung perfusion. The activity was 222 nCi/ml of milk (8.2 kBq/ml) at 2 hr after the MAA injection, and it was found to be excreted exponentially with an effective half-life of 4.6 hr. There was a small incorporation of Tc-99m into breast-milk protein. We conclude that the combined use of these two Tc-99m agents did not indicate the interruption of breast feeding beyond 24 hr after administration of the MAA, and that for an aerosol ventilation study alone, breast feeding need not be interrupted for more than 4 hr after the test.

Adult↗

Potential radiation dose to a breast-fed infant following administration of sodium 32P-phosphate to the mother.

A 32P uptake test to diagnose an intraocular tumour was performed on a lactating woman. Breast feeding of her infant had been stopped and after injection of the 32P, a sample of breast milk on two consecutive days was collected. The concentration of 32P in the milk was greater in the second sample than the first, but it was calculated that the potential whole body radiation dose to her infant on the second day would not have exceeded 180 microSv (18 mrem).

Adult↗

Dual radionuclide subtraction imaging of vertebral disc infection using an 111In-labelled leucocyte scan and a 99mTc-tin colloid scan.

Interpretation of the posterior view of an 111In-labelled leucocyte scan is difficult when infection is suspected in that region of the spine overlaid by the left lobe of the liver. A case is reported of the successful localisation of infection in this region by combining an 111In-labelled leucocyte scan with a 99mTc-tin colloid scan in a dual radionuclide subtraction technique.

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