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Biomedical subjects

F Lutz

Publications and source records attributed to F Lutz.

At least 235 records · Page 13Linked to original sources
PubMed1984

Surface roughness and marginal behaviour of experimental and commercial composites: an in vitro study.

Three experimental inhomogeneous microfilled composites (IMC) containing spherical prepolymerized particles with an interpenetrating network (IPN) were compared with the reference materials Estic MF, Adaptic and the amalgam Dispersalloy in vitro. With surface roughness tests, different polishing procedures were investigated. In addition an SEM analysis of the margins of Class I fillings using a replica technique was performed. With the same technique the proximal boxes of Class II fillings were analysed to further determine the best method to handle the materials clinically. The experimental materials showed a superior adaptation to the walls of proximal boxes of Class II cavities than the reference materials. This superiority was increased by the use of a filled bonding agent. The influence of viscosity, filler load and glass transition point on adaptation and polymerization shrinkage are discussed. It was concluded that especially designed diamonds with very fine abrasive particle size (40 micrograms and 15 micrograms) are the best for finishing and contouring composite fillings. Based on the results of this study it is recommended to use the experimental material for clinical investigations.

Bisphenol A-Glycidyl Methacrylate↗
PubMed1984

In vivo evaluation of occlusal wear of two experimental composites versus amalgam.

Two experimental inhomogeneous microfilled composites with spherical prepolymerized particles and an interpenetrating network (IPN), which provides a stable bond between prepolymerized spheres and the matrix (B-21 and B-51), and amalgam were used for Class II MOD fillings in mandibular molars. After 3 and 6 months of clinical use, wear of the material was measured with a replica technique and a modified surface roughness test. The failure mode was analysed with SEM photographs also using a replica technique. After 6 months the wear of the composites in the occlusal contact area was more than twice as high as the substance loss of amalgam. It was concluded that the composites were not suitable for fillings bearing occlusal load. However, the failure mode seen in the SEM for B-21 indicated that the IPM leads to a stable incorporation of the spherical prepolymerized particles into the matrix. Due to its good surface characteristics B-21 should be further investigated for its use as an anterior composite. B-51 was especially designed as a posterior composite. Beside the construction elements of B-21 it contained also barium glass spheres to obtain radiopacity. This hybrid construction failed due its wear mode.

Bite Force↗
PubMed1984

Effect of Pseudomonas aeruginosa cytotoxin on thymidine incorporation by murine splenocytes.

The interaction of highly purified Pseudomonas aeruginosa cytotoxin (PAC) with murine splenocytes was examined. Added at culture initiation, PAC (0.1 to 0.5 microgram/ml) inhibited subsequent [3H]deoxythymidine incorporation measured between 42 to 48 h. Incorporation of [3H]deoxythymidine was inhibited 50% in lipopolysaccharide-, phytohemagglutinin-, and concanavalin A-stimulated cultures by 0.20, 0.32, and 0.39 microgram of PAC per ml, respectively. It is concluded that PAC exhibits a narrow inhibitory concentration response range of 0.1 to 0.5 microgram/ml which, secondarily, is affected by the presence of mitogens. Antitoxin added at splenocyte culture initiation, directly after PAC, yielded greater than or equal to 86% protection against PAC inhibition of [3H]deoxythymidine incorporation. Addition of antitoxin to cultures at different times after PAC demonstrated a time-dependent loss of antitoxin protective effect over a 12-h period, indicating that PAC became cell associated and refractory to antitoxin within this time period. PAC preincubated with splenocytes at 4 degrees C for less than or equal to 1 h could not be removed by washing of cells and was fully inhibitory to [3H]deoxythymidine incorporation when these cells were cultured at 37 degrees C. This finding was confirmed by demonstrating that 125I-labeled PAC bound immediately to cells. It is concluded that PAC action on splenocytes is dose- and time-dependent and consists of a two-phase process: (i) a very rapid binding of PAC to the cell surface available to antitoxin, and (ii) a slower toxicity development phase of ca. 12 h, during which PAC becomes refractory to antitoxin.

Animals↗
PubMed1984

In vivo and in vitro wear of potential posterior composites.

The influence of cavity size, material composition, and curing mechanism on wear resistance of Class II MOD resin restorations was analyzed quantitatively. Wear resistance tends to increase both as cavity size decreases, and also from chemical- to light- to heat-cured. As to wear, among the composite resins tested, there was no acceptable resin-based amalgam substitute.

Chemical Phenomena↗
PubMed1983

New finishing instruments for composite resins.

The trimming of composite resin restorations encompasses gross finishing, contouring, fine finishing, and polishing. A series of aluminum oxide-coated flexible disks have been marketed and are suitable for that purpose. However, their use is confined to directly accessible convex surfaces. For precise finishing of small delineated areas, and for concave and occlusal surfaces, rigid rotary instruments are necessary. The currently used stones and tungsten carbide burs are ineffective with microfilled composite systems. Thus, a series of finishing burs coated with 40- and 15-microns diamond chips were evaluated because of the superior grinding effectiveness as compared with existing instruments. Surface roughness measurements, and qualitative and quantitative SEM evaluations, indicate that these fine and superfine diamond finishing burs produce surfaces on composite resins as smooth as tungsten carbide burs and stones. At the same time, they cause less surface and subsurface damage or marginal fractures on composite resin restorations. The three-year clinical experience is generally favorable. Further quantitative clinical studies are warranted.

Composite Resins↗
PubMed1983

Generation of leukotrienes and lipoxygenase factors from human polymorphonuclear granulocytes during bacterial phagocytosis and interaction with bacterial exotoxins.

The generation and release of lipoxygenase factors and leukotrienes from human polymorphonuclear granulocytes is demonstrated during bacterial phagocytosis and interaction with bacterial exotoxins (alpha-toxin, enterotoxin, lipase from Staph. aureus; Streptolysin O; cytotoxin from Pseudomonas aeruginosa). The leukotrienes released during stimulation exert chemotactic properties for human neutrophils and guinea pig eosinophils (leukotriene B4) and show the characteristic profile of slow reacting substance activity which is induced by leukotriene C4, D4 and E4. The toxin induced spasmogenic activity obtained from human PMNs was inhibited in the presence of the SRS-antagonist FPL 55712. The generation of lipoxygenase factors is also demonstrated by autoradiography using 14C arachidonic acid prelabelled granulocytes.

Animals↗