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Biomedical subjects

F Kubli

Publications and source records attributed to F Kubli.

At least 127 records · Page 7Linked to original sources
PubMed1977

[The inhibition of prostaglandin induced uterine contractions by diazoxide in vitro (author's transl)].

The tocolytic efficiency of Diazoxide, a benzothiadiazine derivative with pronounced musculotropic action, was tested on the isolated uteri of non-gravid and gravid rats. Regular uterine contractions were induced by the prostaglandines E2 and F2 alpha. Their amplitude and frequency could be suppressed totally or subtotally. Contraction intervals lasted 4--22 min. The basal tone was reduced in most cases.

Animals↗
PubMed1977

[The pattern of distribution of free amino acids in human amniotic fluid related to the duration of pregnancy. Part II: Changes in concentration in pathological pregnancy (author's transl)].

18 free amino acids from 196 specimens of amniotic fluid of pathological pregnancies between the 28th and 41st week of pregnancy were measured by gaschromatography. The concentrations of the amino acids in amniotic fluid in normal and pathological pregnancies were analysed by statistical methods. There were only minor differencies of concentration of free amino acids in the amniotic fluid between normal and pathological pregnancies with the exception of hydroxyproline. This was found in a significantly higher concentration in the amniotic fluid of the pathological group. Supposing that the materno-fetal as well as the feto-maternal amino acid exchange may be reduced by the placenta insufficiency, the significantly higher concentration of hydroxyproline in the amniotic fluid during pathological pregnancies may be caused higher fetal urine excretion of hydroxyproline into the amniotic fluid. The increase of hydroxyproline in the amniotic fluid of pathological pregnancies is probably an early diagnostic parameter of an impaired transplacental exchange -- placenta insufficiency.

Amino Acid Metabolism, Inborn Errors↗