Search PubMed⌕ Search

Biomedical subjects

F Kubli

Publications and source records attributed to F Kubli.

At least 109 records · Page 6Linked to original sources
PubMed1979

[Hormone analyses and ultrasound examinations in high-risk early weeks of pregnancy (author's transl)].

The serum concentrations of HCG, HPL, progesterone and oestriol and ultrasonic findings were compared with one another in 42 women with normal pregnancy course, 51 women with haemorrhages and abortion and 27 women with haemorrhages and delivery on time. Correct diagnosis was most frequently possible with the help of ultrasound examination. However, it was possible to improve the accuracy of the diagnosis before the twelfth week of pregnancy by means of hormone analysis. If the hormone concentrations were normal, whereas ultrasound findings were either negative or not clear, intact pregnancy could be assumed. HCG and progesterone determination possessed the advantage of being reliably measurable even before cessation of menstrual bleeding. From the eighth to ninth weeks of pregnancy, determinations of HPL were also suitable for assessing endocrinal functions. After the twelfth week of pregnancy, the pregnancy conditions could be judged most safely by the ultrasound method.

Abortion, Spontaneous↗
PubMed1979

[The bacterial contamination of epidural catheters with areobe and anaerobe germs in obstetrics (author's transl)].

Following anaesthesia the tips of 105 epidural catheters were investigated for aerobe and anaerobe bacteria. In one case aerobe germs (staphycoccus epidermidis) and in three cases anaerobe germs (propioni-bacteria were isolated. In two further cases aerobic growth was suspected but not confirmed in sub-cultures. The contamination rate was therefore 0.9% aerobe and 4.8% by anaerobe bacteria. Even in the face of a clinically uncomplicated course the presence of bacteria on the catheter tip is considered to be a potential risk for infection. As a preventive measure the skin disinfection procedure was changed and the disinfectant is left for sic minutes instead of three minutes.

Anesthesia, Epidural↗
PubMed1978

Influence of sterilization and temperature changes on the in vitro characteristics of the pH electrode.

1. When chemical sterilization (with Korsolin, Cidex) is performed, a minimal duration of sterilization of 3 h is required for asepsis. 2. Duration of Korsolin sterilization up to 3 h does not influence the in vitro characteristics of the pH-electrode. 3. Sterilization with formaldehyde (24 h, 40 degrees C) is safe, but needs another 24 h restabilization time of the electrode. 4. The temperature dependence of the pH-electrode is minimal. With increasing temperature a slight decrease of pH measurement can be found (-0.02 pH units from 20--40 degrees C).

Disinfectants↗
PubMed1978

In vivo performance of the pH tissue electrode during acute acid-base changes in the dog.

The ROCHE tissue pH-electrode was tested in acute animal experiments under various metabolic conditions. In anesthetized dogs an electrode was placed in the subcutaneous tissue of the scalp, neck, and axilla. Simultaneous with the continuous measurement of tissue pH, the overall acid-base balance of the animal was measured discontinuously at 5-min intervals by means of indwelling arterial and venous catheters. Various forms of acidosis and hypoxia were produced in the experimental animal and the sensitivity of the electrodes in relation to their site was tested. A high correlation between the continuously measured tissue pH values and the corresponding arterial and venous actual blood pH values were found in the physiologic pH range. With acute changes of acid-base balance no correlation could be found in the acidotic range.

Acid-Base Imbalance↗
PubMed1978

A new application tool for the ROCHE pH electrode.

Using this tool the application of the pH electrode is nearly as easy as the attachment of a common ECG-scalp-electrode [3]. Visual control and lithotomy position is not necessary any more. The different tools are adapted to each other so that incision place and the tip of the pH electrode are automatically centered perpendicularly. The first results by using this tool promise to be successful. Time of application is short, the maintenance of the pH electrode is good and the application for the patient no longer disagreeable.

Electrodes↗
PubMed1978

Continuous measurement of tissue pH in the human fetus.

The ROCHE pH electrode was tested clinically in 20 fetuses and one nonviable newborn with severe malformations. The proper fixation of the electrode in the fetal scalp is difficult. In the physiologic pH range a good correlation between capillary blood pH and tissue pH exists. The situation is less clear for the acidotic range.

Capillaries↗
PubMed1978

[Testing the resistance of human tumor and bone marrow cells to cytostatic agents].

Using a short term incubation cell culture method with incorporation of radioisotopes the effect of cyclophosphamide and adriamycin to carcinoma cells and at the same time to bone marrow cells of the same patients has been evaluated in vitro. Instead of cyclophosphamide, ineffective in vitro, 4-Hydroperoxycyclophosphamide was tested. In case of the tumor cells innate as well as drug-induced resistances are obtained in vitro. Different resistance behavior of tumor and bone marrow cells to cyclophosphamide and adriamycin may indicate therapeutic results to be expected in vivo. Simultaneous in vitro resistance testing of tumor and normal cells offers the possibility of better characterization of tumor and host.

Antineoplastic Agents↗
PubMed1978

[Short-term tocolysis of prostaglandin induced uterine contractions comparison between fenoterol and diazoxide (author's transl)].

Uterine contractions were stimulated with a mean dose of 1500 microgram PG in seven pregnant patients between the 14th and 22nd week of pregnancy. The same patients received 300 mg Diazoxide and 20 or 30 microgram Fenoterol alternately in order to tocolize these uterine contractions. After injection of 20 microgram Fenoterol the mean contraction interval lasted for 3.4 min, whereas after 300 mg Diazoxide a mean interval of 48 min was achieved. Side effects after Fenoterol were more marked.

Abortion, Induced↗
PubMed1978

[Fetal damage due to mushroom poisoning with amanita phalloides during the first trimester of pregnancy (author's transl)].

A 25-year old para II suffered of mushroom poisoning by amanita phalloides at 9 weeks gestation. When the life threatening maternal illness was overcome a therapeutic abortion was carried out at 12 weeks gestation. Prostaglandin F2 alpha was injected retro-amniotically. The damage to the fetus by the toxins of amanita phalloides is described and discussed.

Abortion, Therapeutic↗
PubMed1978

[Short-term incubation in vitro with precursors of nucleic acids on human primary tumors and metastases of carcinoma of the breast (author's transl)].

A technique of short-term tests in vitro by means of the incubation of tumor cell suspensions is utilized as a radioactive-biochemical method for pretherapeutic determination of the resistance in human cancers of the breast. Cell suspensions from primary tumors and metastases reveal individually different responses to cytostatics in vitro. It is possible, therewith, to differentiate two tumor collectives related to in vivo resistant or in vivo sensitive tumors. The responses of the primary lesion and the axillary lymphatic metastasis of the same carcinoma may in single cases also differ in vitro, according to clinical experience with the therapy of breast cancer. A distinct relation can be shown between the histological type of a carcinoma and its in vitro capacity of resistance.

Antineoplastic Agents↗
PubMed1978

[Psychosomatic aspects of pregnancy, parturition and puerperium (author's transl)].

Pregnancy, delivery and post-partum period represent not only a special physical strain, but also an extra-ordinary psychic stress. Defective developments and neuroses, especially in the sexual field, as well as improperly adjusted current conflicts, can lead to somatic disturbances. The present-day situation is particularly characterized by the dual role played by the modern woman in society, and the resulting ambivalence of her attitude toward maternity. Over and above this, the technicalization of modern medicine can be associated with a loss of the human relationship between the patient and the physician, so that the patient gets the impression of being at the mercy of an inhuman apparatus. Hence, it is one of the fundamental problems of modern obstetrics not to transgress the limits where technicalization defeats its own purpose and becomes more harmful than useful. Although it cannot be the aim of psychosomatic training in obstetrics and gynecology to train the gynecologist in such a manner that he can also practise formal psychotherapy, it will become more and more important in future to expand our traditionally biologically oriented method of working by the aspect of the interactional and psychosocial fields of life.

Female↗