Search PubMed⌕ Search

Biomedical subjects

F Kubli

Publications and source records attributed to F Kubli.

At least 73 records · Page 4Linked to original sources
PubMed1982

A contribution to the monitoring of fetal arrhythmias.

Antepartum and intrapartum monitoring problems are discussed with reference to a case history of a fetal AV-block detected during the 36th week of pregnancy. CTG instruments where the internal logic criteria can be turned off are suitable for monitoring arrhythmias. During labor the direct fetal ECG permits exact diagnosis as to the type of arrhythmia. The necessity of antepartum diagnosis in regard to postpartum pediatric management and hypoxic states during labor justify the large expenditure on monitoring apparatus. During labor continuous tissue pH measurement via the fetal scalp give added information as to fetal condition.

Adult↗
PubMed1982

Early diagnosis of severe congenital malformations by ultrasonography.

The significance of ultrasound examinations in early stages of pregnancy is illustrated by the detection of four severe congenital malformations within the first trimester and one malformation syndrome within the first part of the second trimester of pregnancy. We report on the diagnosis of a fetal POTTER syndrome (13 weeks), an anencephalic fetus (13 weeks), MECKEL-GRUBER syndrome (16 weeks), fetal exomphalos (12 weeks) and finally "Siamese twins" (11 weeks). Characteristic ultrasonographic findings are presented and described in detail. The incidence of these severe fetal abnormalities vary between 1:1000 (anencephaly), 1:6000 (exomphalos), 3:10,000 (POTTER-Syndrome), 1:50,000 (MECKEL-GRUBER Syndrome) and 1:250,000 (conjoined twins) live births. The sonographical diagnosis of all these malformation syndromes could be established by thorough and repeated inspection of the fetal head and fetal body with longitudinal and transversal scans. It is concluded, that the high and still increasing reliability congenital structural anomalies renders routine systemic ultrasound screening an attractive possibility already at this "early" stage of pregnancy.

Abnormalities, Multiple↗
PubMed1981

Monitoring of HMG-stimulated follicular development by real-time ultrasound.

Monitoring of human follicular development by real-time ultrasound during HMG-HCG treatment is presented. With the aid of ultrasound monitoring, the ovulation rate is raised to 94.3% (formerly 80% without ultrasound). Serious side effects such as ascites and/or hydrothorax did not occur in this study (1.2% without ultrasound controls). The pregnancy rate was 21/47 (44%) of all hormonally treated patients. By means of real-time sector scan examination, the growing follicle could be detected in 103/106 (97.3%) of HMG-HCG treated cycles. Thus real-time ultrasound examinations provide results comparable to those achieved mostly by time-consuming compound scan in demonstration of the growing follicle.

Anovulation↗
PubMed1981

[Ultrasonographic findings in "Potter's syndrome" (author's transl)].

The foetal Potter's syndrome represents a relatively frequent malformation syndrome, the incidence being 0.3% of all live births. The phenotypical changes seen in these newborn occur in complete bilateral renal agenesia = the original Potter's syndrome, but they are also found in various congenital cystic diseases of the kidneys and/or the other urinary organs. In additional to the original Potter's syndrome, a patho-anatomical classification of cystic deformations of the kidneys or of the efferent urinary organs was introduced by Osathanondh and Potter (1976) (Potter Type I-Type IV). These severe foetal malformations can be diagnosed at least in part via timely ultrasonic examination during the first half of the pregnancy period. In such cases, an oligoamnion or sometimes an anhydramnion is regularly observed as principal sign. This diagnosis is probably confirmed if the foetal urinary bladder is not demonstrable following application of furosemide (Campbell). Occasionally the cystic changes of the urinary organs can be proven direct by means of sonography. Ten examples of cases are described presenting the typical ultrasonographic findings in the so-called extended "Potter's syndrome" (oligoamnion or anhydramnion, malformations of the kidneys and/or the efferent urinary organs and phenotypical changes). Due to their infaust prognosis these foetal diseases result in the indication for termination of pregnancy.

Abortion, Legal↗
PubMed1981

[Pyrexia during delivery (author's transl)].

Amnionitis with pyrexia during labor and delivery and the perinatal complications of this syndrome are described. In our series the incidence of pyrexia during delivery was 0.54%. In 70 of 83 cases (84%) an intra-uterine infection was assumed to be the cause of the pyrexia. In 13 of 83 cases (16%) an extra-genital infection was the presumed cause. Intra-uterine infections are a grave danger for the mother and the newborn and constitute a severe complication. The mortality in cases with pyrexia during labor and delivery was elevated to 7 of 83 newborns (9%). Rapid delivery and the timely administration of antibiotics in sufficiently high dosages can prevent the manifestations of severe infections. Recommendations for the obstetric management of cases with pyrexia during labor and delivery are given.

Amnion↗
PubMed1981

[Ultrasound diagnosis of omphalocele during the first trimester of pregnancy (author's transl)].

Ventral defects in the fetus occur in 1/3200 to 1/10,000 deliveries. Prognosis for the newborn is mostly fatal since these anomalies are frequently combined with other congenital anomalies. A through ultrasound study of the fetus in its longitudinal and transverse diameter permits the antenatal diagnosis of this severe fetal anomaly. The earliest diagnosis of the fetal omphalocele in the first trimester of pregnancy is described in detail in this paper.

Abortion, Induced↗
PubMed1981

[A new oxytocin infusion rate recorder (author's transl)].

A new oxytocin-infusion rate recorder system is introduced. It provides continuous plotting dosages on the labor channel of the cardiotocogram. So far 82 conductions of labour were monitored with the new system and evaluated for oxytocin overstimulation. The rate of overstimulations could be reduced resulting in better fetal outcome.

Female↗
PubMed1981

[Diagnosis of siamese twins at 12 weeks gestation (author's transl)].

Double monsters are a rare obstetric event. The mean incidence is approximately 1:50,000 deliveries. The early diagnosis of siamese twins with the aid of routine ultra-sound investigation is described. Typical ultrasound findings and procedures to verify the diagnosis are described in detail.

Abortion, Induced↗
PubMed1981

Effects of crude and purified human chorionic gonadotropin on lymphocyte response.

Human chorionic gonadotropin (hCG) preparations with different biological activities were tested for their inhibitory effects on mitogenic of allogenic induced lymphocyte response. Various crude hormone batches inhibited the lymphocyte reaction in a dose-dependent manner. However, we found a varying suppression of lymphocyte response not correlated to the biological activity (2,660-4,300 IU/mg) of crude hormone. Fractions with very low gonadotropic activity (much less than 500 IU/mg) showed a 100-fold inhibition of lymphocyte reaction. Conversely, the enrichment of highly purified hCG with strong biological activity (greater than 10,000 IU/mg) had no inhibitory effect on mitogenic or allogenic induced lymphocyte transformation. Isoelectrofocussing and immunoelectrophoretic investigations indicated that the inhibition is probably caused by nondialyzable sialoglycoproteins. It is therefore very doubtful whether hCG plays an important part in maternal tolerance of the fetal allograft.

Chorionic Gonadotropin↗
PubMed1981

[Prenatal diagnosis of Meckel-Gruber's syndrome by ultrasound (author's transl(].

The article reports on the ultrasonographic diagnosis of a Meckel-Gruber's syndrome in the 17th week of pregnancy. This malformation syndrome is characterized by the triad: encephalocele, polycystic kidneys, and polydactyly. This congenital disease is compared with malformation syndromes which are distinguishable by differential diagnosis, such as Potter's renofacial syndrome. Thorough ultrasonic examination will be able to detect the severe renal changes as well as the neural tube defects associated with Meckel-Gruber's syndrome. Further diagnostic aids for detecting neural tube defects are, in the first place, the alpha-fetoprotein values obtained from the serum of the mother and/or the amniotic fluid, as well as the determination of acetyl cholinesterase.

Adult↗
PubMed1981

[Determinations of immunoglobulin from the blood of the umbilical vein after pathological course of pregnancy and in foetal growth retardation (author's transl)].

Serum-IgM and serum-IgA concentrations of 561 unselected samples of umbilical cord were determined by the radial immunodiffusion method (Mancini's technique). The mean IgM value of all blood samples was 13.8 mg%. In 9.9% of all cases only we found measurable IgA values, the average IgA concentration being 4.5 mg%. Elevated IgM values (greater than 30 mg%) - pointing to an intrauterine infection - were found to be more frequent (12.1%) in foetal of growth retardation than with newborn of normal body weight, where the incidence of increased IgM values was 5.5% of the examined cases only (however, without a statistically significant difference). In preceding infections during pregnancy, elevated IgM values (greater than 30 mg%) were also found more frequently than in cases without infections (11.8% vs. 5.7%, respectively). Basing on these results, we can suspect that intrauterine infection is one of the possible causes of foetal growth retardation, but not one of the main ones.

Adult↗
PubMed1981

[Sonographic biometry of the fetus-crown-rump-length in the first half of pregnancy].

In 268 pregnant women with known duration of pregnancy the crown-rump-length of the fetus was measured by means of a real-time-scanner. For the period between week 7 + 0 to 20 + 0 normal curves are established. In addition the mean daily incremental rate is given. A maximum increment of 1,9 mm/day was found between week 12 + 0 and 13 + 0. The optimal date for the estimation of the gestational age is the early period between week 7 + 0 an 14 + 0. In this period the 96% confidential range (+/- 2 SD is +/- 7 days. To the end of the first half of pregnancy the precision of the estimation (+/- 2 SD) becomes worse (+/- 10 days). The fetal crown-rump-length could be measured in all cases from up week 7 + 0. Here we see a definite advantage of the real-time-scan-technic-in spite of a diminished precision of measuring - vs the compound-scan-technic.U

Female↗