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Biomedical subjects

F Kubli

Publications and source records attributed to F Kubli.

At least 55 records · Page 3Linked to original sources
PubMed1983

[Ectopic pregnancy--significance of serum human chorionic beta gonadotropins and beta-1-glycoprotein (SP1) determination].

In 83 patients with an ectopic pregnancy the serum levels of HCG and the pregnancy specific beta 1 glycoprotein SP-1 were determined. In addition the serum levels of 25 patients with a nonviable pregnancy and 26 non-pregnant patients were determined. The radio-immunologic beta HCG and SP-1 tests and the enzyme immunologic Sp-1 test were used. The radio-immune assay of beta HCG diagnosed 96% of all cases with an ectopic pregnancy. The enzyme and radio-immunologic SP-1 tests failed to diagnose the ectopic pregnancy in 5 of 83 cases (6%) by the Elisa test and in 3 of 83 cases (4%) by the RIA test. The lower limit of diagnosis of pregnancy was considered to be 1.8 micrograms SP-1/1. The concomitant determination of the beta HCG and the SP-1 level permits the diagnosis of ectopic pregnancy in all cases. The main advantage of the enzyme immunologic determination compared to the radio-immunologic determination is at present the materially shorter time factor of the test and the fact that an isotope laboratory is not necessary.

Chorionic Gonadotropin↗
PubMed1983

[Premature fetal membrane rupture: report of a case of severe intrauterine fungal infection].

A case of extremely rare intra-uterine candida infection is reported following premature rupture of the membranes. The diagnostic possibilities by transabdominal amniocentesis and determination of the causative organism in the amniotic fluid are presented. Even systemic antimykotic treatment is not capable of treating intra-uterine candidiasis sufficiently. This is proved among other parameters by the concentration of miconazol in the amniotic fluid and in the plasma of the newborn.

Adult↗
PubMed1983

Ultrasonic diagnosis of malignant and benign human breast lesions.

Since 1979 445 ultrasound examinations of the breast have been performed. Histological examinations took place in 268 cases. There were 91 patients with 97 carcinomas (5 patients had multicentric carcinomas). In every case x-ray mammography preceded ultrasound examination. The over-all detection rate of malignant breast lesions was 90% by ultrasound examination and corresponded well to the x-ray mammographic findings with 93%. However, false positive results were obtained in 28% of the patients on the basis of sonographic examination. Cysts--with an incidence of 12% in all benign changes in this study--were always correctly diagnosed by ultrasonography. According to these results ultrasonography of the breast may be considered a meaningful additional method to preoperative examination.

Breast Diseases↗
PubMed1982

Diagnosis of intrauterine fetal growth retardation by prolongation of dehydroepiandrosterone sulfate (DHAS) half-life after DHAS loading.

In the last trimester of pregnancy, a correlation was established between the serum dehydroepiandrosterone sulfate (DHAS) half-life of the mother (n = 40) after DHAS loading (50 mg i.v.) and the birth weight percentile of the newborn. The DHAS half-life in pregnancies with normal fetal growth (greater than 10th percentile) was found to be 3.76 +/- 0.91 h (mean +/- SD) (n = 29) and in pregnancies with small-for-date babies (less than 10th percentile) was assessed to be 6.03 +/- 0.63 h (mean +/- SD) (n = 10) (P less than 0.001). Retrospective diagnosis of an intrauterine fetal growth retardation or normal fetal growth was based on a DHAS halflife threshold of 4.7 h. Retarded fetal growth was detected in all cases (10/10) by prolonged DHAS half-life (greater than r.7 h). Regular fetal growth was diagnosed in 90% of the cases (27/30) by a DHAS half-life of less than 4.7 h. In two out of these 30 pregnancies, an unexpected prolongation of DHAS half-life (greater than 4.7 h) led to the false diagnosis of poor fetal growth. In one patient, no DHAS half-life could be calculated due to a parabolic decline of the DHAS concentration curve. Indications for the DHAS test are diagnosis of an ultrasonographically symmetric intrauterine fetal growth retardation (biparietal and thoracic diameters) in cases with an indefinite gestational age. Furthermore, consistently low urinary excretion was clarified with particular respect to cases of placental sulphatase deficiency.

Birth Weight↗
PubMed1982

Ultrasonographic diagnoses of major lymphatic system abnormalities prior to 20 weeks of pregnancy.

Prenatal ultrasound diagnoses of severe lymphatic system abnormalities were obtained in three fetuses. In all three cases the diagnosis was established prior to 20 wk of pregnancy, i.e. early enough to allow selective termination. In all three cases male fetuses with a chromosomal anomaly were found. Alpha-fetoprotein values were not elevated. In all cases the fetal abnormalities were of such size that surgical excision could not be taken into consideration to provide satisfactory results for the infants.

Abortion, Therapeutic↗
PubMed1982

[Diagnosis of intra-uterine growth retardation by intensive ultra-sound biometry].

In a prospective study on 125 maternity patients with suspected intra-uterine growth retardation, simple ultrasound biometry (measuring of the distance) and intensive ultra-sound biometry (measurement of the circumference and the surface) were compared. Of 85 newborn born within two weeks following the biometry 34 newborn had intra-uterine growth retardation with a weight percentile smaller than 5, and 32 newborn were growth retarded with a percentile of 5-10. In 19 cases no growth retardation was found. (12 newborn in this group had a weight percentile 10-25). The measurement of the biparietal diameter was capable of diagnosing at the most 50% of the growth retardations (percentile under 5). The accuracy of the diagnosis of intra-uterine growth retardation increased to 85% with the thoraco-abdominal transverse diameter. The so-called borderline cases (percentile 5-10) were diagnosed with the bi-parietal diameter in 38 percent of the cases and by the transverse thoracic diameter in 41% of the cases. Measurement of the circumference of the head resulted in no better measurements than the bi-parietal diameter. The addition of the measurement of the thoracic circumference increased the diagnosis of severe fetal growth retardation (percentile under 5) to 90% and in borderline cases to 88%. The head thorax index and the ratio of head circumference and thoracic circumference increase in our investigation the accuracy of the diagnosis of intra-uterine fetal growth retardation substantially.

Female↗
PubMed1982

[Diagnosis of intrauterine growth retardation--comparison of clinical findings, total oestrogen determination from 24-hour urine and ultrasound biometry (distance measurement, biparietal head diameter and thoraco-abdominal transverse diameter) considering the antepartal and subpartal CTG's].

This article presents the results of clinical examination, total oestrogen determination from 24-h urine and ultrasound biometry -- measurement of the biparietal head diameter and the thoraco-abdominal transverse diameter (under routine conditions) -- for diagnosing intrauterine growth retardation (IUGR). In addition, the antepartal and subpartal CTG's are evaluated in cases of foetal retardation of growth "Single determinations" are confronted with so-called "serial examinations (= observation of the course)". Repeated clinical examinations and multiple determinations of the total oestrogen elimination with the 24-h urine did not result in any clear improvement of the detection rates of deficient development of the foetus (discovery rate with clinical examination = 54%, total oestrogen determination = 60%); there was, in fact, a relatively high rate of false-positive diagnosis (false-positive diagnoses on clinical examination = 31%). On the other hand, simple ultrasound biometry (distance measurements) led to the discovery of about 78% of all foetal growth retardations (perc. less than 10), the false-positive diagnoses rate being only 9%. Pathological antepartal CTG's (less than 8 points according to the Meyer-Menck score) were seen in about 27% of the cases with growth retardation -- with, however, an approximately equal rate of pathological CTG's in newborn of "normal weight". The discovery rate of deficient development of the foetus has been increased by combining ultrasound biometry with the total oestrogen determination from the 24-h urine, to 88% (perc. less than 10). The same applies to the combination of ultrasound biometry with the clinical examination (rate of detection: 87%). Up to 77% of all cases with IUGR have been discovered both by combining the clinical examination with the total oestrogen determination or antepartal CTG, as well as by combining total oestrogen determination with antepartal CTG.

Abdomen↗
PubMed1982

[The maternal perception of fetal movements during the last trimester of pregnancy].

In a prospective study the foetal movements were simultaneously registered with two real time ultra-sound instruments and compared with the maternal perception of the movements. 35 patients were studied with a mean investigation time of 20 minutes per patient. The mothers pushed a button when they perceived a movements. Synchronous to this registration and storage on a tape were done of the movements of the upper and lower extremities the body movements and the foetal respiratory movements, the foetal heart rate and the uterine contractions. The mothers noticed a total of 38% of all foetal movements. Most frequently the mother noticed in 78% of the cases total foetal movements of the body and extremities. Isolated movements of the foetal body without movements of the extremities were only perceived by the mothers in 31% of the cases and isolated movements of the extremities were only perceived in 15%. In 69% of the cases the mothers correctly indicated that foetal movement took place. In 31% of all maternal signals there was no sonographic evidence of foetal movements of the body or the extremities. In 24% of these cases foetal respiratory movements were evident and in 23% of the cases Braxton-Hicks contractions were found. In 54% of these cases the signal button was used by the mothers without detectable reason. This high failure rate of maternal perception of foetal movements needs to be considered in the evaluation of foetal movements by the mother.

Adolescent↗
PubMed1982

[Sensitivity testing of chemotherapeutic agents for ovarian and breast cancers--possibilities and limits of different methods and of their application (author's transl)].

Well-defined and individualised chemotherapy of human malignant tumours can be initiated with the aid of sensitivity tests for chemotherapeutic agents prior to treatment. The effectiveness of the specific cytotoxic agent can be determined by sensitivity testing. For these investigations three methods are available at present: 1. a short-term incubation method (biochemical assay). 2. an agar-cloning assay as a specific tissue culture method and 3. a heterotransplantation method with transplantation of tumour cells into thymus-aplastic animals. For routine clinical testing only the biochemical short-time assay and the agar colony assay are of practical significance. The test rates and growth rates in the two methods are composed. The in-vitro and in-vivo correlations of sensitivity testing of chemotherapeutic agents and resistance to chemotherapeutic agents in the different test systems show that the accuracy of prediction for the correct positive or correct negative result is 90%. These results are based on retrospective analysis. For the evaluation of the different prediction assays and for the evaluation of the clinical application of these methods only a randomised prospective therapeutic study can give the answers. However, this has not yet been carried out to date.

Animals↗
PubMed1982

[Carcinomatous meningeosis during cis-platinum treatment of gynaecological cancers (author's transl)].

Two cases of carcinomatous meningeosis are reported. One occurred during cis-platinum combination treatment (PAC-scheme) for advanced ovarian carcinoma and one during the same treatment for a carcinoma of the cervix. Both patients showed no neurological problems prior to chemotherapy. The central nervous symptoms developed rapidly following the administration of small doses of cis-platinum (total dose 160 or 300 mg) and could not be controlled. In one case tumour cells were found in the cerebral spinal fluid. The cause of death could have been an unusually toxic reaction to cis-platinum. A thorough neurological examination prior and during chemotherapy with cis-platinum is necessary in order to recognize toxic side effects of the drug as soon as possible.

Adult↗
PubMed1982

Genetics, pathoanatomy and prenatal diagnosis of Potter I syndrome and other urogenital tract diseases.

We report on 12 early prenatal diagnoses of "Potter syndrome" and other severe fetal kidney diseases by ultrasonic observations of persistent oligohydramnios and absence of kidney function; seven pregnancies were terminated. These cases are discussed together with others observed in a total of 23 families. Special attention is given to the difficulty of classifying the various kidney diseases pathoanatomically, and also of determining the recurrence risk in the affected families. For genetic counselling, the possibility of early prenatal diagnosis is a practical solution to this problem. Routine ultrasound supervision of pregnancies can already detect a first, sporadic case of the various kidney diseases.

Abnormalities, Multiple↗
PubMed1982

Distribution of estrogen and progesterone receptors on primary tumor and lymph nodes in individual patients with breast cancer.

Primary breast cancer tissue and lymph nodes were obtained from 55 patients, Histologically, 34 of these patients had positive and 21 negative lymph nodes. Estrogen receptors (ER) and progesterone receptors (PR) were determined by a dextran-coated charcoal assay. The tumor tissue was ER positive in 58% of the cases and PR positive in 34%. The malignant lymph nodes were ER positive in 56% and PR positive in 24%. ER in 14% and PR in 5% of the benign lymph nodes could be detected. The primary tumor tissue and the corresponding malignant lymph nodes showed an identical ER and PR status, i.e. both tumor sites were receptor positive or both receptor negative, in 68 and 74%, respectively. However, 21% of the patients had receptor-positive tumors but receptor-negative lymph nodes. Receptor-positive lymph nodes in combination with receptor-negative tumors occurred in only 11% for ER and 6% for PR. These data show that receptor-positive malignant lymph nodes mostly display the same receptors status as the corresponding primary tumor, whereas receptor-negative lymph nodes may be combined with receptor-positive tumors.

Breast Neoplasms↗