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Biomedical subjects

F Kokot

Publications and source records attributed to F Kokot.

At least 595 records · Page 33Linked to original sources
PubMedDate not supplied

Metabolic effects of long-term arterialization of portal blood.

In nine splenectomized male dogs a splenic artery, -splenic vein shunt was made. Before splenectomy and 3, 6 and 18 months after arterialization of portal blood, different metabolic and endocrine parameters were estimated. Long-term arterialization of portal blood was followed by only insignificant increase of portal vein pressure but a significant drop of pCO2 and increase of pO2 in portal blood was recorded. Simultaneously, a significant decrease of the erythrocyte count, hematocrit value, serum cholesterol and uric acid levels, and a shortening of the T1/2 of insulin and glucagon were found. In contrast, long-term arterialization of portal blood was followed by a significant increase of serum triglycerides, alpha2-globulins, plasma renin activity, cortisol, gastrin and 25-hydroxyvitamin D, and by slight carbohydrate intolerance. No morphological abnormalities in the liver and kidney tissue were found. Data presented in this paper suggest usefulness of a splenic artery-splenic vein shunt in the treatment of some metabolic disorders and of the failing hepatocytes.

Animals↗
PubMedDate not supplied

Mechanism of the post-haemorrhagic vasopressin release from the posterior pituitary lobe.

The mechanism of post-haemorrhagic vasopressin release from the neurohypophysis was studied in rats anaesthetized with urethane. Neurohypophysial vasopressin content was determined according to Dekański and plasma renin activity by radioimmunoassay. In animals bled (1.5% body weight) 60 min after induction of anaesthesia and 30 min after bilateral nephrectomy vasopressin content of the posterior pituitary was significantly higher than in sham-nephrectomized rats. However, when haemorrhage was produced 240 min after induction of anaesthesia and 210 min after nephrectomy, the neurohypophysial vasopressin content was low and similar as that in non-nephrectomized animals. It is concluded that in the phase directly following haemorrhage vasopressin release depends on acute activation of the renin-angiotensin system. Other mechanisms, possibly circulatory reflexes, are involved in the late phase, during prolonged anaesthesia.

Anesthesia↗
PubMedDate not supplied

Metabolic effects of long-term diversion of renal venous blood into the portal system.

In 7 splenectomized dogs a left renal vein-splenic vein anastomosis was performed and the right kidney removed. Eighteen to twenty-four months after portalization of renal venous blood no significant alterations of liver function tests were observed. Long-term diversion of renal venous blood into the liver was followed by a slight increase of creatinine and 25-OH-D, a decrease of alpha-amino acid nitrogen in blood plasma and of plasma renin activity in peripheral blood, by signs of slight carbohydrate intolerance despite hyperinsulinaemia, and a slight decrease of erythrocyte count. No influence of this procedure on plasma proteins, lipids, electrolytes, aldosterone and cortisol was found. No morphological abnormalities in the liver and kidney tissue were found.

Aldosterone↗