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Biomedical subjects

F Kokot

Publications and source records attributed to F Kokot.

At least 577 records · Page 32Linked to original sources
PubMedDate not supplied

Insulin secretion in patients with chronic hepatitis treated with lipostabil.

In 12 patients with chronic hepatitis the carbohydrate tolerance and insulin secretion after intravenous and oral glucose loading were determined before and after lipostabil treatment. A significant rise of fasting insulinemia and hypersecretion of insulin after intravenous glucose loading were observed. After oral glucose loading the rise of insulinemia was significantly lower in patients than in healthy controls, despite a greater increase in glycemia. Administration of lipostabil for 2 weeks failed to exert any significant effect on carbohydrate intolerance and disturbances in insulin secretion, which were present in patients with chronic hepatitis.

Adult↗
PubMedDate not supplied

[Effect of blockade of opiate receptors by naloxone on lutropin (LH), follitropin (FSH) and testosterone secretion in patients after kidney transplantation].

The influence of opioid receptors blockade by naloxone on lutropin (LH), follitropin (FSH) and testosterone secretion induced by LH-RH was assessed in 12 male kidney transplant patients with stable graft function (KTP) treated by cyclosporine A and prednisone and in 15 healthy subjects. In KTP normal plasma levels of LH in spite of significantly reduced testosteronemia and a reduced response of LH to LH-RH was observed. After blockade of opioid receptors by naloxone normalization of the response of LH secretion to LH-RH was found and a higher increase of the plasma testosterone level was observed in KTP than in healthy subjects. Results obtained in this study suggest abnormal functioning of the hypothalamic-pituitary--gonadal axis in KTP and participation of opioid receptors in its pathogenesis.

Adult↗
PubMedDate not supplied

[Blood lipids in patients after kidney transplantation].

In 50 kidney transplant patients [KTP] [37 of them were treated by cyclosporine A and prednisone--CyA group while 13 of them by azathioprine + prednisone--Aza group] serum levels of total cholesterol, LDL-cholesterol, HDL--cholesterol and triglyceride et different time intervals during the first three years after transplantation. The control group comprised 20 healthy subjects. KTP were characterized by significantly elevated plasma levels of total cholesterol, LDL-cholesterol and triglycerides. In KTP treated by CyA+prednisone even an increase of plasma total cholesterol and LDL-cholesterol and a transitory decline of HDL--cholesterol were found as compared with respective basal values. From results obtain in this study it follows, that kidney transplantation does not normalize the lipid profile in KTP, and that KTP treated by CyA are characterized by more marked lipid abnormalities than those on azathioprine therapy. Time after successful kidney transplantation does influence significantly the lipid index of KTP.

Adolescent↗
PubMedDate not supplied

Activity of the renin-angiotensin-aldosterone (RAA) and secretion of the atrial natriuretic peptide (ANP) in patients with chronic renal failure.

In 12 patients with chronic renal failure (CRF) treated with haemodialyses and in 21 healthy controls plasma renin activity (PRA) and the concentrations of aldosterone and atrial natriuretic peptide (ANP) were determined in serum before and after blockade of the angiotensin converting enzyme with captopril. The study was carried out under conditions of the so called bed rest test (BR) and water immersion test (WI). After captopril administration a significant rise of PRA was noted in both groups with a drop of aldosterone level which was significant only in the control group. Captopril administration had no effect on serum ANP level. The results of the study are not suggesting the presence of a close relationship between ANP secretion and the activity of the RAA system in healthy controls and in CRF patients.

Adult↗
PubMedDate not supplied

The activity of the renin-angiotensin-aldosterone (RAA) system and vasopressin secretion in patients with acute non-inflammatory renal failure.

In 12 patients with acute non-inflammatory renal failure (ANRF) and in 21 healthy persons the relationship was studied between the activity of the renin-angiotensin-aldosterone (RAA) system and vasopressin secretion. The study was carried out during the so called bed rest test and during water immersion (WI) after captopril-induced blockade of the angiotensin-converting enzyme. The results of these experiments suggest the absence of a close functional relationship between the activity of the RAA system and vasopressin secretion in patients with ANRF and in healthy controls.

Acute Kidney Injury↗
PubMedDate not supplied

Central action of catecholamines on the cardiovascular system in rats.

Central action of catecholamines on the cardiovascular system in rats. Acta Physiol Pol., 1978, 29 (2): 123--130. It was demonstrated that noradrenaline, adrenaline, dopamine and isoproterenol as well as normethanephrine administered into the lateral ventricle of the rat brain, under urethane anaesthesia, caused significant changes in arterial blood pressure. This action is due to stimulation of central adrenergic receptors. Arterial blood pressure rise after intraventricular administration of noradrenaline is caused by activation of the renin-angiotensin system in the periphery. The results of these experiments point to a role of central catecholamines in functional regulation ofthe cardiovascular system.

Animals↗
PubMedDate not supplied

[Treatment of anemia in patients with renal failure using erythropoietin obtained by genetic recombination].

In 5 haemodialyzed patients with end-stage renal failure an effect of human recombinant erythropoietin (r-huEpo) on haemoglobin, haematocrit and iron metabolism was studied. After 12 weeks of the treatment, a significant increase in haemoglobin and haematocrit but significant decrease in plasma ferritin were noted. During r-huEpo treatment, one patients presented clinical symptoms of increased blood coagulation whereas another patients an increase in blood pressure. r-huEpo did not influence leukocytes and platelets count as well as liver function tests. Our results suggest, that r-huEpo is highly effective and safe in the treatment of anaemia in patients with chronic uraemia. Iron metabolism, blood pressure and blood coagulation must be monitored during therapy with r-huEpo.

Adult↗
PubMedDate not supplied

Water immersion (WI) induced alterations of plasma vasopressin (AVP) levels in patients with noninflammatory acute renal failure (NARF) and in patients with chronic renal failure (CRF).

Water immersion (WI) induced alterations of plasma vasopressin (AVP), plasma osmolality, plasma volume (PV) and plasma sodium and potassium concentration were examined in 12 patients with noninflammatory acute renal failure (NARF) at the anuric/oliguric phase, 20 patients with chronic renal failure (CRF) and 15 healthy persons. In all examined groups a significant increase of PV and decrease of plasma osmolality and AVP after WI was observed. In patients with NARF the increase of PV was significantly greater than in CRF and in healthy persons. In patients with NARF a significantly greater decrease of plasma sodium concentration after WI was also noted than in patients with CRF and in healthy persons. Only in healthy persons, but not in patients with acute or chronic renal failure a significant correlation between PV or decrease of plasma osmolality and WI induced decrease of plasma AVP level was stated. We conclude that patients with NARF and CRF are characterized by an inappropriate volumetric and osmotic regulation of AVP secretion.

Acute Kidney Injury↗
PubMedDate not supplied

[Studies of atrial natriuretic peptide, diuresis and natriuresis in patients with diabetes mellitus types 1 and 2 after water immersion].

In 30 diabetics (15 with type I and 15 with type II) and in 15 healthy controls the effect was studied of two-hour immersion in water on the concentration of atrial natriuretic peptide, sodium and potassium in serum, diuresis and natriuresis, mean arterial pressure and percent change of circulating plasma volume. Diabetics with either type of diabetes differed from the controls by a significantly lower concentration of the atrial natriuretic peptide under basal conditions, and lower rise of the peptide during immersion in water. Type I diabetics differed from type II diabetics and controls in that their natriuresis was lower under basal conditions and during immersion. On the basis of these results the authors conclude that in diabetics the reaction of atrial natriuretic peptide secretion to central hypervolaemia is preserved but weaker, and the role of this hormone in the pathogenesis of increased diuresis and natriuresis induced by water immersion is smaller in these patients than in controls.

Adult↗
PubMedDate not supplied

Water immersion induced alterations of plasma atrial natriuretic peptide (ANP), diuresis and natriuresis in kidney transplant patients.

UNLABELLED: The present article aimed to study the intactness of the physiological mechanism of ANP secretion in 64 kidney transplant patients treated with cyclosporine A + prednisone (CyA group--35 patients) or azathioprine + prednisone + promethasine respectively (Aza group or--29 patients). The control group comprised 15 healthy persons. ANP plasma levels were assessed before and 1 h and 2 h after neck out water immersion (WI). Higher basal ANP levels were found in patients of the CyA and Aza group than in normals (significantly higher in patients of the CyA group). WI induced an increase of plasma volume (PV) which was of comparable magnitude in all examined groups. It was accompanied by a significant increase of plasma ANP, diuresis and of natriuresis, which was significantly lower in transplanted patients than in normals. Only in healthy persons a significant positive correlation was found between the WI induced increase of plasma ANP and diuresis and natriuresis respectively. CONCLUSIONS: 1) kidney transplant patients are characterized by an intact, although reduced response of ANP secretion, diuresis and natriuresis to central hypervolaemia; 2) WI induced increase of diuresis and natriuresis does not seem to be only dependent upon ANP secretion in kidney transplant patients; 3) kind of immunosuppressive therapy seems to be of importance in the pathogenesis of altered ANP secretion in kidney transplant patients.

Adult↗
PubMedDate not supplied

Water immersion induced alterations of plasma adrenaline and noradrenaline levels in patients with endstage renal failure (CRF) and in healthy persons.

Water immersion (WI) induced alterations of adrenaline and noradrenaline levels were examined in 20 patients with chronic renal failure (CRF) and 15 healthy persons. In patients with CRF a significantly elevated mean arterial blood pressure (MAP), a markedly elevated plasma level of adrenaline but only a slightly elevated concentration of plasma noradrenaline were observed as compared with healthy persons. In all examined groups WI induced significant decrease of mean arterial pressure and plasma adrenaline and noradrenaline levels. In patients with CRF the WI induced a decrease of MAP and of plasma adrenaline was significantly more marked, while that of plasma noradrenaline was significantly less than in healthy persons. Results presented in this study suggest the existence of an impaired function of the sympathetic nervous system, mainly of the beta-adrenergic one in CRF.

Adult↗
PubMedDate not supplied

[Effect of water immersion on levels of atrial natriuretic peptide in patients with chronic renal failure].

An effect of a 2-hour water immersion on the blood serum ANP was investigated in 20 haemodialysed patients with chronic renal failure and in 15 healthy individuals. Water immersion produced an increase in volume in both healthy individuals and the patients of similar degree. Baseline ANP concentration (290.0 +/- 21.9 pg/mL) was significantly higher in the dialysed patients than that in healthy individuals (66.0 +/- 5.5 pg/mL). Water immersion decreased mean arterial pressure (previously significantly higher in the patients) in both healthy individuals and examined patients, significantly increased secretory renal function (significantly higher in healthy individuals than in the examined patients), and increased ANP (previously significantly higher in healthy subjects). A significant correlation between ANP level in blood serum and changes in volume was seen only in healthy individuals. The obtained results suggest a contribution of other than changed volume factors of ANP release regulation and other than ANP factors to pathomechanism of post-immersion drop of the arteria blood pressure and increased secretory renal function in both healthy individuals and patients with renal failure.

Adult↗
PubMedDate not supplied

Water immersion induced alterations of atrial natriuretic peptide in patients with noninflammatory acute renal failure.

Water immersion (WI) induced alterations of plasma atrial natriuretic peptide (ANP), circulating plasma volume (PV), plasma, sodium and potassium level and mean blood pressure (MAP) were examined in 12 patients with noninflammatory acute renal failure (ARF) and in 15 healthy persons. In patients with ARF a significantly elevated basal ANP level (138.67 +/- 12.9 pg/ml versus 74.54 +/- 4.1 pg/ml in healthy persons and elevated MAP (111.9 +/- 3.5 mmHg in patients versus 87.3 +/- 1.8 mmHg in healthy persons) were found. WI induced a significant increase of plasma ANP level in both examined groups which was significantly more marked in healthy persons (152.42 +/- 12.82 pg/ml) than in patients with ARF (85.75 +/- 12.62 pg/ml). WI was accompanied by a significantly more marked reduction of MAP (22.6 +/- 2.9 mmHg) and sodium level (6.09 +/- 0.63 mmol/l) in patients with ARF than in healthy persons (12.07 +/- 1.52 mmHg and 4.2 +/- 0.11 mmol/l respectively). In contrast to healthy persons in patients with ARF WI did not induce enhanced diuresis. In patients with ARF a significantly more marked increase of PV was found than in controls. Data obtained in this study seem to prove preservation of the physiological regulatory mechanism of ANP secretion in ARF patients but reduction of ANP release induced by central volume expansion. The importance of elevated basal plasma levels in the maintenance of ARF has not been proven.

Acute Kidney Injury↗
PubMedDate not supplied

[Study of vibration sensation in the aspect of disorders of calcium-phosphate metabolism in patients with chronic renal failure].

A group of 72 patients with chronic renal failure (22 non-dialysed and 50 hemodialysed) were studied for the behaviour of the threshold of vibratory sensibility in upper and lower limbs at frequencies of 125 and 250 Hz. The patients dialysed were examined just before hemodialysis. All the patients were studied for the following parameters: concentration of calcium, inorganic phosphates, PTH, creatinine, uric acid in the blood serum and the activity of general alkaline phosphatase and its thermolabile fraction (osseous). The patients dialysed differed from the patients non-dialysed in higher creatinine, uricemia and the activity of alkaline phosphatase, both general and its "osseous" fraction. But they did not differ significantly in the concentration of phosphates, PTH and calcemia . Two thirds of patients with chronic renal failure, both dialysed and non-dialysed, revealed a significant increase in the threshold of vibratory sensibility, better marked in lower limbs then in upper limbs. As opposed to patients non-dialysed, patients dialysed did not show a significant correlation between the level of PTH in blood serum and the threshold of vibratory sensibility. Dialysotherapy did not influence significantly the frequency of disorders in vibratory sensibility. Considering the fact of almost identical frequency of disorders in vibratory sensibility both in patients dialysed and non-dialysed and also the lack of correlation between the level of lesion of vibratory sensibility and the concentration of PTH in blood serum, the participation of parathormone in the pathogenesis of uremic neuropathy seems to be doubtful.

Adult↗