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Biomedical subjects

F Kokot

Publications and source records attributed to F Kokot.

At least 451 records · Page 25Linked to original sources
PubMed1977

Cobalt-activated acylase activity in experimental toxic liver damage.

Co++-activated acylase activity was studied in the blood serum and liver homogenates from rabbits poisoned with CCl4 in doses of 0-5 g/kg body weight intraperitoneally. Activity of this enzyme in serum increased on the first day after poisoning, but the rise was of short duration. Increased serum activity of the enzyme was accompanied by an increase in acylase activity in liver homogenates, which persisted to the ninth day, i.e. to the end of the observation period, when serum acylase activity returned to normal. Co++-activated acylase activity in serum was not correlated with its activity in liver homogenates. Co++-activated acylase activity was significantly correlated with AlAT and GGTP activities, but acylase and LAP were not correlated.

Alanine Transaminase↗
PubMed1976

[Behavior of the plasma renin activity and aldosterone after salt restriction and upright posture in essential hypertension].

In 100 patients with essential hypertension and 50 healthy subjects the relation between plasma renin activity (PRA) and plasma aldosterone level (Ald) was investigated. PRA as well as plasma aldosterone was estimated a) after a diet with normal sodium content (equals 120 mEq per day) provided for 3 days and after an 8 hrs rest ("L" value of PRA and Ald) and b) after sodium restriction (10 mEq per day) for 3 days and 3-4 hrs ambulation ("A" value of PRA and Ald). Concerning the behaviour of "L"- und "A"-PRA all patients were divided into 4 groups: a) patients with normal, b) rigid, c) low and d) high PRA. Despite differentiated values of PRA in patients of all groups a normal increase of the plasma aldosterone level was stated after sodium restriction in the diet and upright position. Even in 18% of healthy subjects with low PRA a normal increase of Ald after sodium restriction and upright position was observed. These results seem to prove that in patients with low and rigid PRA and in 18% of healthy subjects the renin-angiotensin system is not the main or only regulator of aldosterone secretion.

Adult↗
PubMed1976

[Endocrine disorders in patients with essential hypertension].

Patients with so-called essential hypertension are heterogenous concerning the behaviour of the renin-angiotensin-aldosterone system and the activity of the sympathetic nervous system. They may display low, normal or high plasma renin activity. In a certain number of patients other hormonal abnormalities can also be deomonstrated. Among these abnormalities the following are to be mentioned: elevated aldosteronaemia, decreased metabolic clearance of aldosterone, lack of suppressibility of aldosteronaemia and plasma renin activity after salt load, elevated plasma level of 18-OH-DOC and progesterone. Only in some patients with essential hypertension disturbances of the metabolism of catecholamines can be stated. This could indicate, that altered activity of the sympathetic nervous system may be a pathogenetic factor in the development of essential hypertension only in some of the patients. The role of prostaglandins in the pathogenesis of essential hypertension is not yet proved.

Aldosterone↗