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Biomedical subjects

F Kokot

Publications and source records attributed to F Kokot.

At least 415 records · Page 23Linked to original sources
PubMed1981

Thyroid function in patients with acute renal failure.

Thyroid function was evaluated in a group of 36 patients with acute renal failure (ARF) during the oliguric/anuric, polyuric and postpolyuric phase. Serum thyroxine (T4) and triiodothyronine (T3) concentrations were significantly decreased in the oliguric/anuric phase, as compared with the mean values obtained in the post-polyuric phase and with controls. In contrast to T3 and T4, the concentration of serum reverse triiodothyronine (rT3) was elevated in the oliguric/anuric phase and normal in the polyuric phase. The sephadex-T3-binding index (T3I) was significantly increased in oliguric/anuric patients and in the polyuric phase. The levels of serum thyreotropin were significantly elevated during all phases of ARF as compared with the controls. From the results obtained it is concluded that abnormal peripheral metabolism of T4 seems to be the primary cause of altered plasma concentrations of thyroid hormones in patients with ARF.

Acute Kidney Injury↗
PubMed1981

25-hydroxyvitamin D in patients with essential hypertension.

Plasma 25-OH-D levels of normotensive and hypertensive subjects living in a highly industrial and in a nonindustrial area, were estimated. Significantly higher values were found in normotensive subjects than in hypertensive patients. Severity of arterial hypertension was not related to plasma 25-OH-D. Both groups of subjects (normotensive and hypertensive) living in the industrial area with high air pollution had lower 25-OH-D concentrations than those living in the nonindustrial region. Data presented in this paper suggest that antihypertensive treatment by pharmacologic agents exerts a depressive effect on plasma 25-OH-D level.

25-Hydroxyvitamin D 2↗
PubMed1980

[Endocrine changes in chronic renal failure].

Endocrine abnormalities are common symptoms in patients with chronic renal failure. They are characterized by: 1. excessive somatotropin and prolactin secretion, 2. increased peripheral conversion of T4 to rT3, 3. secondary hyperparathyroidism accompanied by a relative insufficiency of calcitonin secretion, 4. hypogonadism, 5. hyperinsulinism and 6. decreased erythropoetin and 1,25-dihydroxy-vitamin D synthesis. In patients with chronic renal insufficiency normal function of the renin-angiotensin-aldosterone system, and pituitary-adrenal axis and normal PgA and PgE2 secretion are found. Increased blood levels of some peptide hormones (e.g. glukagon, gastrin) in patients with chronic renal failure seem to be caused, at least partially by secretion of biologically inactive prohormones and their decreased renal clearance.

Angiotensin II↗
PubMed1980

Serum 25-hydroxyvitamin D in patients with chronic renal failure on long-term treatment with high doses of vitamin D2.

The present study was aimed at answering the following two questions: (1) What is the effect of high dose vitamin D treatment on the serum level of 25-hydroxyvitamin D (25-OH-D) in patients with chronic renal failure (CRF)? (2) Is there any effect of urinary protein loss on the serum 25-OH-D levels during treatment with pharmacological doses of vitamin D? 42 patients with CRF were studied. They were treated conservatively by a low protein diet and received 15 mg of vitamin D2 once a week. Long-term administration of vitamin D caused a significant (5- to 7-fold) increase of plasma 25-OH-D level irrespective of the degree of proteinuria. This increase was noted only during the first 5 months of vitamin D2 treatment. Surprisingly only in some patients moderate hypercalcemia (> 2.75 mmol/l) was found. From the results obtained it is concluded that (1) patients with CRF differ from normal subjects in handling of high doses of vitamin D and (2) high dosage treatment with vitamin D may prevent hypocalcemia in patients with CRF in spite of high proteinuria.

Adult↗
PubMed1980

Concentration of 25-hydroxyvitamin D in serum of infants under the intermittent high-dose vitamin D3 prophylactic treatment.

The concentration of 25-hydroxyvitamin D was measured in serum of 90 healthy and 123 sick infants. The mean concentration of 25-OH-D in the group of healthy infants given intermittent prophylactic doses of vitamin D3 was 44.0 microgram/l and was nearly three times higher than the average concentration in healthy adults not given any vitamin D substitution. In the 123 clinically treated infants the average 25-OH-D concentration was 86.2 microgram/l, and 59.4% of infants had values over 40 microgram/l. In the subgroup of infants admitted to the hospital because of diarrhea, lower values were found than the average ones of clinically-treated infants. Two children with clinical rickets had very low 25-OH-D concentrations. The 25-OH-D half life in serum of infants varied from 19 to 27 days and single dose--300,000 IU (7.5 mg) of vitamin D3 was found to assure a sufficient 25-OH-D concentration in serum for as many as 190 days. It is concluded that high intermittent oral doses of vitamin D3 give an effective protection against rickets but at the cost of several times higher 25-OH-D concentration in serum and at the risk of hypervitaminosis D in some healthy infants.

25-Hydroxyvitamin D 2↗
PubMed1980

Metabolic effects of long-term diversion of renal venous blood into the portal system.

In seven splenectomised dogs a left renal vein-splenic vein anastomosis was performed and the right kidney removed. Eighteen to twenty-four months after portalisation of renal venous blood no significant alterations of liver function tests were found. Long-term diversion of renal venous blood into the liver was followed by a slight increase of creatinine and 25(OH)D3, a decrease of alpha-amino acid nitrogen in blood plasma and of plasma renin activity in peripheral blood, by symptoms of slight carbohydrate intolerance despite hyperinsulinaemia and a slight decrease of erythrocytosis. No influence of this procedure on plasma proteins, lipids, electrolytes, aldosterone and cortisol was observed. No morphological abnormalities in liver and kidney tissues were found.

Animals↗
PubMed1979

[Serum gastrin in patients with acute kidney failure].

In 18 patients with acute renal failure and 11 patients with chronic renal insufficiency serum gastrin levels were estimated before and after a test meal. The results were compared with those obtained in a group of 52 healthy subjects. It was stated that patients with acute as well as chronic renal failure display a "physiological" increase of serum gastrin after stimulation by a test meal. In contrast to healthy subjects the post-test meal gastrin curves in patients with chronic and acute renal insufficiency during the anuric/oliguric phase started from significantly higher fasting values. From the results obtained it seems that diminished renal clearance of gastrin by the insufficient kidneys is only partially responsible for the elevated fasting values found in anuric/oliguric patients with acute renal failure or patients with chronic renal insufficiency.

Acute Kidney Injury↗
PubMed1979

[Parathormone, calcitonin, 25-hydroxycalciferol and bone histology in patients with chronic renal insufficiency].

In 18 patients with chronic renal failure the parathormone (PTH), calcitonin (CT) and 25-OH-D blood levels were estimated before and after an intravenous calcium load. In ten patients the above mentioned biochemical parametres were confronted with histological findings obtained in bone biopsy material. Significantly elevated levels of PTH and CT were found while those of 25-OH-D were normal. Serum PTH decreased after a calcium load. In contrast to healthy persons no increase of serum CT was stated. Significant positive correlations were found between PTH and CT levels in blood serum as well as between the mineralized bone volume and 25-OH-D levels in serum. In addition a significant negative correlation was stated between the osteoid volume and 25-OH-D levels in blood serum. From the results obtained it is concluded, that from estimations of PTH, CT and 25-OH-D in blood serum histological alterations in bone biopsy material from chronic uremic patients can not be predicted. Beside secondary hyperparathyreoidism, relative deficiency of CT and active vitamin D metabolites other factors are also involved in the pathogenesis of renal osteodystrophy.

Adult↗