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Biomedical subjects

F Kase

Publications and source records attributed to F Kase.

At least 37 records · Page 2Linked to original sources
PubMed1985

[Hemostatic mechanisms and malignant tumors].

The mutual relationships between malignant tumours and mechanisms of blood coagulation are presented in a brief survey. In this connection, the mechanisms of a tumour cell entering the circulation through the vessel well and its leaving into the tissues are discussed, the theory of microtrauma being used for explaining these processes. Subsequently, the alterations to be found in the count and function of thrombocytes after contact with a malignant cell and the impact on this cell by blood platelets are represented. As a third factor the activation of blood coagulation which is exercised by substances with a procoagulatory effect produced by the malignant tissue and the frequently observed thrombosis in the course of neoplastic diseases are dealt with in connection with blood level changes of some coagulation factors. In a fourth section the significance of fibrinolysis, its activation and inhibition as well as the production of fibrinolytic activators by neoplasms are discussed.

Animals↗
PubMed1985

[A case of hypereosinophilic syndrome].

A report is presented on a case of hypereosinophilic syndrome (HES) characterized by an increase of leukocytes to 70.0 X 10(9) per litre and a percentage of eosinophils up to 87 per cent in the differential hemogram. As a peculiarity hitherto not described increased values were observed in 4 immunoglobulin fractions, IgA, IgG, IgM and with an extreme content of IgE of more than 40.000 IU/ml.

Eosinophilia↗
PubMed1984

Basic haematological values in antelopes--II. The Hippotraginae and the Tragelaphinae.

Basic haematological values in 49 animals of five species of the subfamily Hippotraginae, namely the roan antelope Hippotragus equinus, sable antelope Hippotragus niger, adax antelope Addax nasomaculatus, gemsbok oryx Oryx gazella gazella and scimitar horned oryx Oryx damah and in 51 individuals of five species in the subfamily Tragelaphinae, including the bushbuck Tragelaphus scriptus, nyala Tragelaphus angasi, greater kudu Tragelaphus strepsiceros, cape eland Tautotragus oryx and bongo Bocercus euryceros are reported. The erythrocyte counts were in the range of 12.62 X 10(12)/l in the gemsbok oryx to 6.44 X 10(12)/l in the bongo, the haematocrit values varied from 0.488 in the nyala to 0.380 in the roan antelope and for the haemoglobin highest levels (164.0 g/l) were noted in the adax antelope, and the lowest (105.5 g/l) in the bongo. Leukocyte counts were found mostly in the normal human range and varied from 7.17 X 10(9)/l in the adax antelope to 4.05 X 10(9)/l in the nyala, only in the greater kudu decreased values of 3.02 X 10(9) were estimated. These results are compared with findings taken from the literature, and with the normal human range.

Animals↗
PubMed1984

Basic haematological values in antelopes--III. The Reduncinae and the Antelopinae.

Basic haematological values were measured in 50 individuals of five species falling under the subfamily Reduncinae, including the mountain reedbuck (Reduncula fulvorufula), the eastern waterback (Kobus ellipsiprymnus ellipsiprymnus), the defassa waterbuck (Kobus ellipsipyrmnus defassa), the lechwe waterbuck (Kobus leche) and the Lady Gray's waterbuck (Kobus megaceros) and in 45 animals of three species of the subfamily Antelopinae, including the springbok (Antidorcas marsupialis), the Grant's gazelle (Gazella Granti) and the dama gazelle (gazella dama). The highest mean erythrocyte counts were found in the male springbok: 11.72 X 10(12)/l, the lowest in the lechwe waterbuck: 8.39 X 10(12)/l, the mean haematocrit values varied from 0.538 in the lechwe waterbuck to 0.443 in the defassa waterbuck and the mean haemoglobin content ranged from 181.2 g/l in the male springok to 151.8 g/l in the defassa waterbuck. Leukocyte counts were mostly shown to be in the human range, in the subfamily Reduncinae at the lower limit; only in the mountain reedbuck decreased values of about 3.5 X 10(9)/l were demonstrated. These results are compared with information from the literature and with the normal human range.

Animals↗
PubMed1984

Basic haematological values in antelopes--IV. A comparison and concluding remarks.

Comparison of mean erythrocyte counts, mean haematocrit values, mean haemoglobin content and mean corpuscular volume of the red cell is presented for 21 species of antelopes (four species being excluded because of the small number of animals investigated). A direct relationship of haematocrit values and haemoglobin content and an inverse relationship of red cell counts and mean corpuscular volume of the erythrocytes were noted. The significance of an increased total surface area for oxygen exchange is discussed and values obtained in the red blood picture are compared with those of domesticated animals (cattle, goat and sheep) taken from the literature. Mean leukocyte counts were found to be in the human range with the exception of two species, but significantly lower than in domesticated artiodactylids. Problems in assessing the general health, the age, the effect of diet and of environment in captivity are discussed. Problems of methodology, especially of blood sampling, are given comparing results in manually restrained and in sedated animals.

Animals↗
PubMed1983

[The physiological inhibitors of blood coagulation. 1. Antithrombin III (AT III)].

In a brief survey, recent data on the molecular structure and functions of antithrombin III as well as on the similarity of identity with antithrombin III of newborns and mammals are referred to. Moreover, the survival time in circulation and its broad inhibiting spectrum comprising not only all activating factors of coagulation, but also other proteases, is discussed. The accelerating effect of heparin on response and possible mechanisms of this acceleration are discussed. The various procedures of determination are briefly dealt with. Furthermore, the distinct tendency towards thromboembolic complications occurring in patients with only a slight reduction of antithrombin III level is dealt with, as it was described in inherited and acquired deficiency of antithrombin III. Finally, the possibilities of therapy for this deficiency are discussed and is underlined on the key position of antithrombin III for maintaining the balance of coagulation.

Antithrombin III↗
PubMed1983

[Physiologic inhibitors of blood coagulation. 2. Alpha 2-macroglobulin, alpha-antitrypsin and the C1 inhibitor of complement].

Three physiological inhibitors of blood coagulation - alpha-2-macroglobulin, alpha-1-antitrypsin, and C-1-inhibitor of complement - are dealt with in a brief survey. The point is that these are proteins of the organism with a defence character which are also able to inhibit an extraordinarily broad spectrum of proteases. Some recent findings about their molecular structure, manner of response, and inhibitory spectrum are represented. Comparisons are made to corresponding proteins in mammals, in alpha-2-macroglobulin and even in lower vertebrates. Moreover, the inherited deficiency of these three inhibitors are represented with respect to human diseases and changes of their blood level in the course of various diseases are referred to.

Animals↗
PubMed1983

Formation of cholic acid from 3 alpha, 7 alpha, 12 alpha-trihydroxy-5 beta-cholestanoic acid by rat liver peroxisomes.

In a previous study, it was shown that the peroxisomal fraction of rat liver, isolated by Percoll gradient centrifugation of a light mitochondrial fraction, was able to catalyze conversion of 3 alpha, 7 alpha, 12 alpha-trihydroxy-5 beta-cholestanoic acid (THCA) into cholic acid (Pedersen, J. I., and J. Gustafsson, 1980. FEBS Lett. 121: 345-348). In the present work, this peroxisomal THCA-oxidizing system has been studied in more detail. The peroxisomes were prepared by sucrose gradient centrifugation. By use of different marker enzymes, it was confirmed that the major part of the activity in the light mitochondrial fraction was located in the peroxisomes. The reaction was absolutely dependent on the presence of Mg2+, CoA, ATP, and NAD+ in the reaction medium. In addition to cholic acid, small amounts of 3 alpha, 7 alpha, 12 alpha, 24-tetrahydroxy-5 beta-cholestanoic acid were detected as product. Provided the peroxisomes were preincubated with ATP and CoA, the reaction was linear with time up to 75 min. It was linear with peroxisomal protein and the pH optimum was 8. The reaction was stimulated by FAD (ca. 50%), by cytosolic protein (about twofold), by microsomal protein (about twofold), bovine serum albumin (about sevenfold), and by KCN (75% at 1 mM). In the absence of bovine serum albumin in the medium the K'm for the overall reaction was 1.4 X 10(-6) M and the maximum rate was 4.3 nmol X mg-1 X hr-1. In the presence of bovine serum albumin, the K'm increased to 6.3 X 10(-6) M and the maximum rate to about 32 nmol X mg-1 X hr-1.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1981

[Review. Endotoxins and blood coagulation].

The impact of blood coagulation caused by endotoxins (ET) is reported in a survey. In this connection the activation of factor XII by ET and the activation of the intrinsic system of coagulation due to it are discussed, the mechanism of blood platelet damage with subsequent thrombocytopenia is dealt with, and the induction for liberating of a thromboplastin-like procoagulant from leukocytes as well as the factors influencing this liberation are described. Furthermore, the mechanisms leading to the damage of the endothelia cell are discussed and the correlations to the complement system are described. On the basis of facts known up till now special attention is devoted to the role of the thromboplastin-like procoagulant and the activation of the extrinsic system caused by it in developing a DIC syndrome.

Blood Coagulation↗
PubMed1980

[An interferon-like substance derived from bird fibroblasts in the treatment of human recurrent herpes simplex].

In a clinical study lasting 15 months 42 patients suffering from herpes simplex were locally treated with an interferonlike substance prepared on avian fibroblast cultures. In 90% of all cases a certain improvement was achieved. In 60% reduced intensity and in 57% a shortening of prodromal symptoms was established, reduced dimensions of skin lesions were noted in 75%. In 21 patients only abortive forms without vesicles appeared. The mean duration of the herpetic episodes was reduced from 10.1 days to 4.5 days. Finally the possible mechanism of this favourable effect are discussed.

Animals↗
PubMed1979

[Phospholipids and blood coagulation].

After a simplified survey of the chemistry of phospholipids (PL) their presence in the lipid part of thromboplastin is dealt with, the significance of this structure being stressed. In addition, the condition, mode of action and synthesis of PL in blood platelets are extensively discussed and the impact of the composition of thrombocytic PL in the membrane and granular fraction by plasma lipid substances is referred to. The relations between single forms of PL and those proteins activating coagulation are represented and the conditions for the development of such activating complexes are referred to. Subsequently the coagulation stimulating properties of PL, thromboplastin, thrombocytes, and artifically produced PL are compared and the attempt is made to draw certain conclusions from sometimes contradictory results. Finally, the anticoagulative effect of phosphatidylserin is referred to.

Animals↗