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Biomedical subjects

F J Marshall

Publications and source records attributed to F J Marshall.

At least 37 records · Page 2Linked to original sources

Shape constancy and polar perspective.

The distortion of polar perspective depends on the depth of the tridimensional shape and on the observation distance. In four experiments using 54 undergraduates as subjects, we found that a compensation process which takes depth and observation distance into account corrects for such distortions. Compensation was demonstrated in experiments in which deceptive information on depth and on observation distance was provided. The result was distortions of the perceived shapes that would be expected if compensation were based on the deceptive information.

Cues↗

Age-related changes in reducible crosslinks of human dental pulp collagen.

Coronal pulp of human third molars from patients ranging in age from 16 to 40 yr was analysed for collagen, protein, calcium and reducible crosslink content. Dihydroxylsinonorleucine (DHLNL) was the major crosslink; it decreased with age. Hydroxylsinonorleucine (HLNL) and lysinonorleucine (LNL) appeared in insignificant amounts. Calcium content increased with age. Based on the premise that collagen synthesis is characterized by the presence of reducible crosslinks, the study showed that coronal pulp collagen synthesis decreases with age; this is accompanied by a decrease in collagen concentration in terms of dry weight and total protein between 16 and 30 hr of age.

Adolescent↗

Conjunctivitis and skin erythema. Outbreak caused by a damaged high-intensity lamp.

Eighty-one members of girls' basketball teams were exposed to ultraviolet light while sitting in the bleachers of a school gymnasium. A mercury high-intensity discharge lamp lighting the bleacher area had a hole in its outer envelope that allowed the emission of ultraviolet light. Sixty-nine (85%) of the 81 girls were affected; 49 (71%) had symptoms of conjunctivitis and 63 (91%) had symptoms of erythema.

Accidents, Home↗

Metabolism of the antimicrobial agent nibroxane, 5-bromo-2-methyl-5-nitro-m-dioxane, in the rat.

1. The metabolism of nibroxane, a topically effective antimicrobial agent has been studied in the rat after oral and dermal administrations. 2. Plasma level studies in vitro and in vivo showed nibroxane to be rapidly debrominated to 2-methyl-5-nitro-m-dioxane. 3. Nibroxane is rapidly absorbed and extensively metabolized in the rat regardless of the route of administration. 4. Enzymic hydrolysis of the m-dioxane ring was of major importance in the biotransformation of nibroxane. The major eliminated metabolite in the rat was 2-nitropropan-1,3-diol.

Administration, Oral↗