[The current problems in the development of Russian medical science. Interview by A. P. Lomakin].
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Biomedical subjects
Publications and source records attributed to F I Komarov.
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The schedule of estulic administration for stage I-II essential hypertension in more effective at lower doses and better tolerance when adjusted to circadian variations in arterial pressure. Six-month continuous estulic treatment results in regression of left ventricular myocardial hypertrophy.
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The studies have revealed that the type of gastric mucosa changes in the patients with duodenal ulcer correlates with the disease severity, and manifestations of the pathologic processes in the gastric mucosa depend on the stage of duodenal ulcer. The most grave changes in the gastric mucosa were revealed in the patients with hereditary predisposition to peptic ulcers. In contrast to normal subjects, gastric mucosa status in the patients with duodenal ulcer is liable to season-associated changes, these changes being the most manifest in spring and fall.
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The article discusses the results of dynamic echocardiographic examination of 46 patients with chronic ischemic heart disease before and after 15-day treatment with agents capable of blocking beta-receptors: propranolol (anaprilin), pindolol (visken), talinolol (cordan) which were prescribed in mean therapeutical doses. It is shown that agents blocking beta-adrenergic receptors lead to regular decrease in the indices of myocardial contractility. The character of changes in the volumetric characteristics of the left ventricle depends on the initial levels of arterial pressure and the degree of its dynamics during treatment with beta-adrenergic blocking agents. In patients with chronic ischemic heart disease developing against the background of hypertensive disease the dynamics of changes in the volumetric indices depends on the degree of arterial pressure reduction.
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The state of pulmonary hemodynamics and the contractile function of the right parts of the heart were studied clinically and instrumentally in 35 patients with diffuse chronic pathological conditions of the liver. The lungs and heart were examined morphologically in 24 persons who had died from cirrhosis of the liver in the edematous-ascitic stage. Pulmonary hypertension was found to be directly dependent on the degree of the diffuse affection of the liver. Secondary-compensatory changes in the contractile function of the myocardium of the right parts of the heart in response to increase of pressure in the pulmonary artery in patients with cirrhosis of the liver were proved to occur.
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