The histochemistry of dark cells in the vestibular labyrinth.
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Biomedical subjects
Publications and source records attributed to F Hiraide.
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This report describes the histopathological changes in the temporal bone of a 71-year-old man who died of meningitis and epidural abscess complicated by primary squamous cell carcinoma of the middle ear. The present case is unusual and differs somewhat from previously reported cases of the primary squamous cell carcinoma of the middle ear in three respects: 1) an extensive invasion of the cancer into the membranous labyrinth, 2) cholesterol deposits in the cochlear spiral canal, and 3) presence of ossifying labyrinthitis. Among these findings, extensive involvement of the inner ear by cancer destroying the lower part of the otic capsule is particularly unusual. It is assumed that squamous cell carcinoma overcame the biological resistance to neoplastic infiltration which probably exists in the otic capsule and the membranous labyrinth.
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Following local application of various degrees of negative pressure to the middle ear, the authors observed changes in vascular permeability in guinea pigs, using Majno's vascular labelling technique. Increased permeability and effusions were seen in all experimental middle ears. Any pressure below -5 mm of mercury induced middle ear effusions. Accordingly, a decrease in pressure developed in the middle ear cavity may cause transdation of serum drawn from the submucosal vessels, resulting in fluids in the middle ear of aero-otitis. In such a circumstance, mast cells which are easily influenced by atmospheric pressure may be involved in increasing vascular permeability.
Chronic infection and allergy are considered to be the two major etiologic factors of nasal polyps. Whatever its cause may be, the initial phase of nasal polyp formation is represented by increased exudation from vessels, edema of the lamina propria and the bulging of the nasal mucosa. Nasal polyps were histologically classified into three types: edematous type, glandular and cystic type (ductal type) and fibrous type. Those of the edematous type and the glandular and cystic type are in the active stage of tissue reaction because of permeation of vascular fluid and marked infiltration of round cells. Contrastingly, the fibrous type polyps are in the healing stage of tissue reaction because of marked proliferation of fibroblasts and collagen fibers. The morphological structure of the nasal glands involved in the bulging mucosa determines the type of nasal polyps, whether edematous type or glandular and cystic type.