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Biomedical subjects

F Hiraide

Publications and source records attributed to F Hiraide.

At least 37 records · Page 2Linked to original sources
PubMed1982

Experimental cholesterol granuloma. Histopathological and histochemical studies.

The authors have induced experimentally middle-ear effusions and cholesterol granulomas one month and later after tubal obstruction in squirrel monkeys. Cholesterol crystallization has occurred frequently in the middle-ear fluids of three-and six-month-animals, and, typical cholesterol granulomas were noted in four of the eight middle ears of six-month-monkeys. The shape and size of the cholesterol crystals were variable, depending upon the surrounding cells of fluid. In middle-ear effusion, the crystals formed rather large rectangular structures, which tended to become smaller and thinner, as the granulomas developed. The granuloma containing cholesterol crystals was rich in various oxidative and hydrolytic enzymes. The large cells surrounding the crystals show intense-to-strong enzyme activity and probably play a phagocytic role in the developing and healing processes of the granuloma.

Animals↗
PubMed1981

Histochemical study of the efferent nervous system in the guinea pig inner ear.

The efferent nervous system of the guinea pig inner ear is histochemically investigated. Remarkable activity of alkaline phosphatase and acetylcholinesterase is demonstrated by Burstone's (1958) azo dye method and Koelle's (1949) method as modified by Gomori (1952) respectively. The distribution pattern of both enzymes in the efferent nervous system is entirely similar. The intraganglionic spiral bundles, fascicles of the osseous spiral lamina and efferent plexus of the organ of Corti reacted intensely for both enzymes. Afferent nerve fibers give no histochemical reaction for both alkaline phosphatase and acetylcholinesterase. However, spiral and vestibular ganglion cells are rich in both enzymes, though they belong to the afferent nervous system. The significance of both enzymes in the nervous system of the guinea pig inner ear is briefly discussed.

Acetylcholinesterase↗
PubMed1980

The fiber arrangement of the pathological human tympanic membrane.

Remarkable morphological changes of the fiber arrangement was observed in the middle lamina propria of the pathological human tympanic membranes. These changes were present mainly in the middle zone of the pars tensa. There were several fibers running in entirely different directions among the regularly arranged radial and circular fibers. These abnormal fibers had a tendency of forming fiber bundles of varying sizes and lengths. It is stressed that the normal fiber arrangement was undoubtedly disordered in the healing process of the inflamed middle lamina propria of the human tympanic membrane.

Aged↗
PubMed1980

Unusual blood vessels in the cochlea of the squirrel monkey.

Unusual blood vessels in the cochlea of the squirrel monkey are reported. The blood vessels in Reissner's membrane and basilar membrane are occasionally found in the course of the experimental middle ear study. The blood vessel of Reissner's membrane derives from a radiating arteriole in the upper spiral ligament and takes a straight course down to the inner surface of the spiral limbus, running on the scala vestibuli side of Reissner's membrane, and finally joins the venous vessel of the spiral limbus. Two blood vessels are noted in the basilar membrane of basal turn, running fairly parallel to each other from the tympanic lip to the basilar crest of the spiral ligament in the same cochlea. It is confirmed that these unusual blood vessels derive from the radiating arterioles in the osseous spiral lamina and connect with the venules of the basilar crest in the spiral ligament. Although unusual blood vessels in both Reissner's membrane and basilar membrane are thought to be vestigial structures, they contain a remarkable amount of alkaline phosphatase in their walls. This suggests that these unusual vessels have actually functioned until their death. Multiple occurrence of unusual blood vessels in both Reissner's membrane and basilar membrane of the cochlea of various animals, including man, has not yet been reported in the literature as far as we have been able to ascertain. Incomplete devascularization in the developing process of the cochlea may possibly be the cause of such unusual conditions after birth.

Animals↗
PubMed1980

The fine surface structure and composition of salivary calculi.

Salivary calculi were formed by a laminated mixture of inorganic and organic substancs. However, there was no regular pattern for the growth of stones, as laminal thickness and the arrangement of the laminal component were not uniform. Finger-like radial projections, longitudinal pavements or amorphous structures were seen on the fractured surface of the calculi. No inert foreign body or microorganism was found in the calculi. There were two modes of formation in calculous nucleus, one developed by maturation of a primitive core, the other formed in homogenous mineral mass. X-ray microanalysis proved that most salivary calculi contained chemical elements such as calcium, phosphorous, potassium, sodium, magnesium, chlorine, sulfur, manganese, chromium and aluminum. As far as we have examined, these elements were distributed with almost equal density throughout the calculus.

Calcium Carbonate↗
PubMed1979

Alkaline phosphatase activity in the ganglion cells in and near the temporal bone.

The distribution pattern of alkaline phosphatase was studied in the ganglion cells in and near the temporal bone of some mammals. No or extremely weak activity of alkaline phosphatase was observed in or near the spiral and vestibular ganglion cells of the bat, rat, cat, and monkey. However, intense to moderate enzyme activity was noted exclusively in the peripheral areas of the spiral and vestibular ganglion cells of the guinea pig. The enzyme activity was also demonstrated in the nerve fibers at some distance from both axonal and dendritic processes of the spiral and vestibular ganglion cells of the guinea pig. Trigeminal and geniculate ganglion cells of all mammals examined showed intense to moderate enzyme activity in their capsular cells. There is a marked difference in the phosphate metabolism in the capsular tissues of the ganglion cells in or near the temporal bone of various mammals.

Alkaline Phosphatase↗
PubMed1976

Sudden deafness. A histopathological study.

Histopathological studies were performed in the temporal bones from a 77-year-old woman who had bilateral sudden deafness 31 years before her death. The common findings in both cochleas were atrophy of the organ of Corti and stria vascularis, and degeneration of the tectorial membrane. Pathology of the tectorial membrane consisted of atrophy and droplet formation of the middle and marginal zones. In one area, an atrophied tectorial membrane was lifted up by a mass on the limbus. The saccular wall in the left temporal bone was ruptured. There was no pathology in the vascular system in the labyrinths except for moderate degeneration of sensory epithelium. The pathogenesis of sudden deafness was discussed in the light of the present findings. Alteration of the tectorial membrane seemed to be the main factor as a possible cause of sudden deafness. Histopathological findings were reviewed from the literature.

Adult↗
PubMed1975

Alkaline phosphatase activity in the inner ear blood vessels of some mammals.

The distribuation pattern of alkaline phosphatase in small blood vessels was studied histochemically in the stria vascularis and spiral ligament of various mammals. No or extremely weak activity of the enzyme was demonstrated in the walls of the blood vessels in bat and rabbit, while moderate to intense activity was found in guinea pig, cat, squirrel monkey and man. There was a species difference in the phosphate metabolism in the walls of the inner ear blood vessels.

Alkaline Phosphatase↗
PubMed1975

Alkaline phosphatase activity in the inner ear of fetuses, newborn and adult guinea pigs.

The distribution pattern of alkaline phosphatase in the inner ear of fetuses, newborn and adult guinea pigs is described. In the inner ear of fetuses, remarkable alkaline phosphatase was noted throughout the entire tissue of spiral ligament, statoacoustic nerve fibers and the wall of small blood vessels. In newborns, however, less enzyme activity was seen in the spiral ligament and statoacoustic nerve. In adult guinea pigs, no enzyme activity was detectable in the spiral ligament and statoacoustic nerve fibers except for the wall of small blood vessels and efferent nerve fibers. It is evident that the distribution pattern of alkaline phosphatase is altered during the development of the inner ear of the guinea pig.

Alkaline Phosphatase↗