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Biomedical subjects

F Hecht

Publications and source records attributed to F Hecht.

At least 271 records · Page 15Linked to original sources
PubMed1977

Chromosome 14 translocation in African and North American Burkitt's lymphoma;.

Two established North American Burkitt lymphoma cell lines were studied by chromosomal banding techniques. The SU-AmB-1 line previously shown to be negative for the Epstein-Barr virus (EBV) was found to have, among other changes, a translocation from the long arm (q) of chromosome 8 onto 14q. The SU-AmB-2 line, which contains the EBV genome, also displayed the same 8/14 translocation. These results were compared with data from three EBV-positive tumor cell lines derived from patients with African Burkitt's lymphoma. Our findings indicate that a translocation from 8q onto 14q occurs in both African and North American Burkitt lymphomas, and that this abnormality apparently is not related directly to EBV. This chromosome translocation therefore may be an important event in the development of human lymphocytic malignancy, analogous to the occurrence of the Philadelphia chromosome rearrangement in chronic myelogenous leukemia.

Adolescent↗
PubMed1976

9p trisomy identified by Giemsa-11.

The Giemsa-11 technique specifically stains the secondary constriction region of chromosome 9. We report cytologic evidence for 9p trisomy in a 4 1/2-year-old girl with moderate retardation and multiple anomalies, using the Giemsa-11 technique.

Abnormalities, Multiple↗
PubMed1976

Re-evaluation of the effect of spray adhesives on human chromosomes.

The possible effects of spray adhesives on human chromosomes were re-examined in several ways by three different laboratories. A total of 3,382 metaphases were analyzed in a blind-coded fashion. The proportion of abnormal cells, including gaps, was similar in both the control (8.2%) and exposed (8.3%) samples. Our findings do not confirm the original investigation in which the proportion of abnormal cells was found to be significantly higher in the exposed group (8.99%) than in the control group (1.65%). In the earlier study, however, blind-coded slides were not employed. These and other studies show no positive evidence of an effect of spray adhesives on human chromosomes.

Adolescent↗
PubMed1976

Estimating distances from the centromere by means of benign ovarian teratomas in man.

Under the assumption that benign ovarian teratomas in man arise parthenogenically from a germ cell by suppression of the second meiotic division, the distance of a gene from its centromere can be estimated from the observed proportion of heterozygous teratomas collected from heterozygous hosts. The frequency of heterozygous teratomas of heterozygous hosts is equivalent to the frequency of second division segregation at the gene locus which has been used for centromere-related mapping in fungal genetics for more than 40 years. Mapping functions useful for teratoma-based mapping in man are presented.

Chromosome Mapping↗
PubMed1976

Human centromere mapping using teratoma data.

Under the assumption that benign ovarian teratomas arise parthenogenetically from a germ cell by suppression of the second meiotic division, the proportion gamma of heteratomas collected from heterozygous hosts is a measure for the distance between the corresponding gene and its centromere. For proportions gamma less than or equal to 0.3, the mapping function x = gamma/2 applies, where x is the map distance in Morgans.

Cells, Cultured↗