Search PubMed⌕ Search

Biomedical subjects

F Hassanyeh

Publications and source records attributed to F Hassanyeh.

31 records · Page 2Linked to original sources
PubMed1984

Alaproclate--an open clinical study in depressive illness.

This open study of alaproclate points towards an antidepressant effect in a a relatively chronic and drug-resistant group of depressives. Five patients had an average improvement of more than 21 points on the Hamilton Rating Scale for Depression and six had an average improvement of seven points. Several patients had anticholinergic side effects, abnormal results in liver functional tests and faecal occult blood, but none were bad enough to require being taken off the drug and most side effects improved before the end of the trial. The biochemical results suggested that the responders and non-responders constituted two distinct biological groups. In the patients who responded well to treatment there were increases in Km values consistent with treatment. The Km and 5-HT values correlated strongly with plasma drug values. There was a strong correlation between Hamilton Rating scores in the 4th week and Km values in the 4th week, although there were only five cases. However, there were no significant relationships between improvement and any pretreatment value. These results are sufficiently promising to suggest that a controlled clinical trial would yield information on alaproclate as a therapeutic aid.

Adult↗
PubMed1983

Serum concentration of depot neuroleptics in tardive dyskinesia.

Using radioimmunoassay techniques, serum levels of depot neuroleptics, fluphenazine and flupenthixol, were estimated in two groups of chronic schizophrenic patients with, and without, tardive dyskinesia. There were high significant difference in dose-related serum levels of either drug between the groups. The hypothesis that patients with tardive dyskinesia develop the syndrome because they do not metabolise neuroleptics as efficiently as those without the syndrome was not supported by the data.

Dyskinesia, Drug-Induced↗
PubMed1981

Self-mutilation.

Explore the source record for details and available documents.

Adult↗
PubMed1980

Bipolar affective psychosis with onset before age 16 years: report of 10 cases.

Ten patients, 5 male and 5 female, with bipolar psychosis beginning before the age of 16 years, mean 14.1 years, are described. Difficulties in diagnosis in this age group are discussed and background factors of possible aetiological importance analysed. Lithium therapy was effective in 6 out of 7 patients.

Adolescent↗
PubMed1976

Familial Behçet's syndrome.

Behçet's syndrome is reported in a family of which four generations have so far been affected. The index patient also exhibited an unusual schizo-affective disorder. The histocompatibility antigen haplotype 1-17 was common to four with the disease. Genetic transmission may be responsible for the familial nature of the syndrome and the associated schizophrenia.

Adult↗