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Biomedical subjects

F Hassanyeh

Publications and source records attributed to F Hassanyeh.

At least 19 recordsLinked to original sources
PubMed1994

Long-term outcome of post-partum psychiatric illness requiring admission.

Among 65 women admitted to a mother and baby unit within 6 months post-partum, 53 were followed up for an average of 8.8 years. Women who had no previous history of psychiatric illness or who had experienced previous puerperal illness only, did significantly better at follow-up. The majority of these women had presented with a clinical picture of major depression. Past psychiatric history is confirmed as an important prognostic indicator in post-partum illnesses.

Adolescent↗
PubMed1994

Biological correlates of deliberate self-harm behaviour: a study of electroencephalographic, biochemical and psychological variables in parasuicide.

Clinical, electroencephalographic and biochemical variables were measured in 40 patients who attempted suicide and 27 age-matched controls. Patients had significantly higher scores for depression, hopelessness, neuroticism and psychoticism and lower scores for extraversion than controls. They also had significantly lower contingent negative variation (CNV), higher postimperative negative variation and lower whole blood serotonin values than controls. Within the patient group, vulnerability to parasuicide, as determined by previous or repeated acts of deliberate self-harm, was associated with higher scores for hopelessness and suicide intent, lower scores for extraversion and decreased CNV. Factor analysis revealed significant correlations between psychological variables and auditory evoked potential amplitudes for the vulnerable group. A profile of variables associated with increased risk of self-harm in patients presenting with attempted suicide is proposed from our data.

Adolescent↗
PubMed1991

The role of unemployment in parasuicide.

Sixty-four in-patient cases of deliberate non-fatal self-poisoning were compared for psychosocial problems in a case-control study with a similar number of individually matched community controls. A strongly significant association was found between unemployment and self-poisoning. Further analysis revealed no firm evidence to support the hypotheses that unemployment was causally related to self-poisoning in an indirect manner or that it increased the vulnerability of individuals who self-poison to other stressful life events and difficulties. It is concluded that a possible explanation is that some third factor independently increases the risk of both unemployment and self-poisoning, giving rise to a non-causal relationship between these last two variables.

Adaptation, Psychological↗
PubMed1991

Measures of serotonin metabolism in anorexia nervosa.

Thirty-five consecutive attenders at a clinic specializing in anorexia nervosa were studied. All conformed to a DSM-III-R diagnosis for anorexia nervosa. In addition, 3 cases suffered from major depressive disorder and 9 from dysthymia. Blood from all patients was analysed for monoamine oxidase, serotonin (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA), tryptophan and platelet paroxetine binding. Findings showed that blood 5-HT was higher than normal in all patient groups, and was highest in those having affective disorder with anorexia nervosa. However, of the patients with anorexia nervosa alone, a subgroup having greatest weight loss had blood 5-HT levels significantly below all other groups. Lack of significant changes in other parameters compared with normal subjects points to the possibility of abnormal 5-HT storage or release.

Adult↗
PubMed1990

Estimation of human blood plasma 5-hydroxyindoleacetic acid and homovanillic acid.

A method for simultaneous quantification of plasma homovanillic acid and 5-hydroxyindoleacetic acid has been developed, permitting more efficient neurochemical examinations of these often interrelated biogenic amine systems. Zinc sulphate and sodium hydroxide solutions were used for precipitating the protein in plasma prior to injection on the column. This technique allows for cleaner chromatography, greater sensitivity and high precision. The method uses high performance liquid chromatographic separations of these compounds on C18 reversed phase columns with electrochemical detection. The detailed results from controls and untreated parasuicide patients are given.

Chromatography, High Pressure Liquid↗
PubMed1990

Primary and secondary erotomania: clinical characteristics and follow-up.

A survey within a defined area of the north-east of England (population of approximately 1.25 million) generated a number of patients with current or past erotomanic phenomenology. A casenote study was carried out on the 11 patients identified. Cases were classified in accordance with DSM-111-R criteria and an assessment was made of the extent to which each case fulfilled specific criteria for primary and secondary erotomania, as defined by previous authors. The response to treatment of both psychiatric syndrome and erotomanic phenomenology is described for each case. The findings are discussed in relation to the current debate regarding the status of de Clerabault's syndrome and delusional disorder (erotomanic type) as nosological entities.

Adult↗
PubMed1990

Hostility, hopelessness and deliberate self-harm: a prospective follow-up study.

Sixty-one consecutive patients who presented following an episode of deliberate self-harm (DSH) were assessed on a number of variables, including measures of hopelessness and hostility. Attempts were made to follow all of the patients. Those who were known to have had a further episode of DSH had significantly higher levels of hopelessness and intropunitive hostility after the index episode than those who did not repeat. The question of vulnerability to DSH is discussed as well as the possibility of using measures of hopelessness and intropunitive hostility to identify those at greater risk of repetition.

Adolescent↗
PubMed1990

Pica in a patient with anorexia nervosa.

A case of an unusual pica in a patient with anorexia nervosa is described. The patient was also found to have iron-deficiency anaemia. The relationship of mineral deficiency to pica and anorexia nervosa is discussed.

Anemia, Hypochromic↗
PubMed1989

Repeat self-harm: an 18-month follow-up.

An 18-month follow-up of cases of deliberate self-harm (DSH) revealed that 30% had repeated the act. Of a large number of items recorded at index DSH only one, a past history of self-harm, was associated with repetition. It is suggested that some factors not predictive of longer term repeat DSH may be important in the assessment of risk for immediate further self-harm.

Female↗
PubMed1988

Cortical evoked potentials and clinical rating scales as measures of depressive illness.

Relationships between clinical ratings and cortical evoked potentials were examined before and during antidepressant drug treatment in 32 patients with major depressive disorder (DSM-III). Clinical rating scales included Hamilton Rating Scale for Depression, Beck Depression Inventory, Present State Examination (PSE) and Newcastle Scale. Evoked potentials included contingent negative variation (CNV), post-imperative negative variation (PINV) and auditory evoked potential (AEP) There were close correlations between all rating scales, and factor analysis produced only one component, suggesting that the common variance between them related to severity of depression. CNV magnitude before treatment correlated negatively with severity of depression regardless of diagnostic category. Depressed patients had a prominent PINV which persisted during antidepressant treatment. The amplitude of late components (N1P2) of the AEP was reduced strikingly in patients with a history of suicide attempts.

Adult↗
PubMed1988

The dexamethasone suppression test in bulimia nervosa.

In a study of the dexamethasone suppression test (DST) in patients with bulimia nervosa, a non-suppression rate of about 50% was found. The only clinical correlates of DST non-suppression were a previous history of weight loss and/or of anorexia nervosa. These results suggest that DST non-suppression in these subjects may be a trait rather than a state marker of anorexia nervosa.

Adult↗
PubMed1987

Deliberate self harm--correlates of suicidal intent and severity of depression.

In a study of 98 cases of deliberate self harm, a high correlation was obtained between a diagnosis of Major Depressive Disorder (M.D.D.) and scores on both the Hamilton Rating Scale for depression (HRS) and the Suicide Intent Scale (SIS). There was also a high correlation between HRS and SIS scores. A higher score on HRS and SIS correlated with increasing age, as also did a diagnosis of M.D.D.

Adolescent↗
PubMed1987

Age and self-poisoning: the epidemiology in Newcastle upon Tyne in the 1980s.

The epidemiology of 737 consecutive self-poisoning admissions to Freeman Hospital, Newcastle upon Tyne, has been investigated with reference to age in young (less than 35), mid-aged (35-64) and elderly (greater than or equal to 65 year) patients. The most important differences were increased formal psychiatric illness in the elderly, demonstrated by increased likelihood of admission to psychiatric units; less likelihood of overdose with multiple agents in the elderly, and less use of alcohol. There were also differences in the types of drugs used. The youngest patients took more paracetamol and less psychoactive drugs and more of their drugs were prescribed for a relative than the other two groups. The elderly were much less likely to receive gastric lavage or emesis and more likely to receive supportive treatment only than younger patients. This difference may, in part, be explained by the more frequent occurrence of benzodiazepine poisoning in those over 65 years.

Adolescent↗