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Biomedical subjects

F Hartveit

Publications and source records attributed to F Hartveit.

At least 109 records · Page 6Linked to original sources
PubMed1980

Breast carcinoma: treatment failures in "early" and "late" disease.

Review of 86 autopsied cases of disseminated breast carcinoma showed that the scatter in survival time and pattern of metastatic distribution was similar in those with and without node involvement at operation. There were tumour cells in the efferent vessels in 86% of cases with tumour-bearing nodes, this factor being thus associated with a "late" carcinoma, one in which latent metastatic spread was present at the time of operation. While one cannot distinguish between an "early" tumour confined to the breast, and a potential treatment failure in which tumour emboli may have passed the nodes without colonizing them, the present findings indicate that such a distinction may be real.

Adult↗
PubMed1979

Paranodal vascular spread in breast cancer with axillary node involvement.

The presence of tumour cells in the efferent paranodal vessels of tumour-bearing axillary lymph nodes from patients with operable breast carcinoma was associated with a significant reduction in survival time at 5 yr compared to cases with node involvement in which these vessels did not contain tumour cells.

Axilla↗
PubMed1979

Autopsy findings in cases with a clinically uncertain cancer diagnosis.

Analysis of the post mortem and clinical evaluation of the underlying cause of death in 471 cancer patients showed that doubt in the clinical situation occurred in approximately one case in four. Doubt was of three kinds, that as to the site of origin of the cancer, that related to lack of morphological confirmation and that as to the aetiology of the disease process. In most cases in the first two groups the decision not to resolve the doubt until post mortem was made clinically. The majority of the others were admitted too late for the doubt to be resolved before death.

Adult↗
PubMed1977

Clinical and post-mortem assessment of the cause of death.

Analysis of the clinical and post-mortem assessment of the underlying cause of death in 742 autopsies showed that over- and underdiagnosis cancelled each other out in the majority of the main diagnostic groups, so there was little difference in the total number of cases recorded in the different groups after clinical and post-mortem investigation. However, in the individual case the reliability of the clinical diagnosis varied greatly with the nature of the diagnosis and its degree of certainty. Reliability was for example high with clinically certain arteriosclerotic heart disease and low with cerebrovascular disease. Underdiagnosis of lung cancer is still a problem. Lack of interest in autopsy investigation may be reflection of lack of clinical involvement or therapeutic frustration rather than the use of sophisticated diagnostic procedures, as has been assumed by previous authors. It is suggested that the idea of selection of cases for autopsy should be replaced by selection of autopsies for microscopic investigation on the basis of the macroscopic post-mortem findings. It is suggested also that clinicians might profitably attend autopsies on patients in their sphere of interest that were not admitted under their care.

Age Factors↗
PubMed1976

Aorto-oesophageal fistula complicating carcinoma of the oesophagus. Review of the literature and report of a case following irradiation and cytostatic therapy.

Aortic perforation complicating carcinoma of the oesophagus is extremely uncommon. In keeping with findings in the literature, the aortic wall in this case was damaged by secondary changes following irradiation and Bleomycin treatment. Extensive necrosis of normal tissues was a prominent feature and it is suggested that the action of radiation in combination with cytostatic therapy on normal tissues need further investigation.

Aged↗
PubMed1975

Fatal haemorrhage following atraumatic liver rupture secondary to post-operative perforation of the gall-bladder. A case report.

A case of post-operative perforation of the gallbladder with massive intraperitoneal haemorrhage is presented. The clinical picture was complicated by urinary infection and bleeding from an acute gastric erosion. It is suggested that the antibiotic treatment given for his urinary infection may have altered the clinical course of his cholecystitis, allowing a silent perforation to take place and present in the form of an atraumatic liver rupture.

Acute Disease↗
PubMed1973

Prognostic typing in breast cancer. Further investigation of a necropsy series compared with recent surgical specimens.

A comparison of material from necropsy and surgical series has shown that breast carcinoma of cytological types II and III are rare. The majority of cases are of type I. Of the latter, tumours in TNM stage I were not found in the necropsy series, while infiltrating duct carcinomas of type I TNM stage II were also absent. This suggests that the possibility of surgical cure may be better in type I duct carcinomas in stage II than with other histological types. Prolonged survival in contrast to surgical cure was related to type III tumours irrespective of TNM stage.

Adenocarcinoma↗