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Biomedical subjects

F Hartveit

Publications and source records attributed to F Hartveit.

At least 91 records · Page 5Linked to original sources
PubMed1982

Oestrogen and progesterone receptor content and the distribution of histological grade in breast cancer.

Histological grading of 160 primary infiltrating breast carcinomas showed that both oestrogen and progesterone receptor status are strongly related to grade, tumours that are receptor positive tending to be of lower grade than the receptor negative. The nuclear factors used in grading were those that determined this association. In addition the absence/presence of both receptors was reflected in the grade present, beyond the correlation expected on the basis of either receptor alone.

Adult↗
PubMed1982

Stromal metachromasia: a marker for areas of infiltrating tumour growth?

The presence of stromal metachromasia is reported in 23 of 38 cases of invasive carcinoma of the uterine cervix, its absence from 34 of 35 'in-situ' lesions. The metachromasia was seen at the zone of host/tumour interaction. Its presence was associated with changes in the morphology of the stromal cells and adjacent mast cells. The implications of these observations to the interpretation of tumour histology are discussed.

Carcinoma in Situ↗
PubMed1982

The sinus reaction in the axillary nodes in breast cancer related to tumour size and nodal state.

The sinuses of the axillary nodes were studied in 59 breast cancer patients. Three types of reaction were defined in them; sinus histiocytosis, a mixed sinus reaction, and sinus catarrh. Sinus histiocytosis, as defined here, was virtually confined to the mode-negative cases; sinus catarrh, common to both node-negative and positive, but increasing with tumour size in the former. It is suggested that transition may occur from sinus histiocytosis, via the mixed reaction, to sinus catarrh, and that the establishment of the latter may facilitate tumour spread.

Axilla↗
PubMed1982

Mast cells and the nodal sinus reaction in breast cancer.

Mast cell counts in the sinuses of axillary nodes from breast cancer patients are shown to vary with the type of sinus reaction present. Few scattered mast cells were found in association with sinus histiocytosis. A mixed reaction, in which fewer histiocytes were present and more round cells, was accompanied by a significant increase in mast cell count, which in sinus catarrh showed a decrease. The possible rôle of sinus mast cells in relation to tumour spread is discussed.

Axilla↗
PubMed1981

Histological grade and efferent vascular invasion in human breast carcinoma.

Primary breast carcinomas (23) with axillary-node metastases that also showed tumour cells in the efferent nodal vessels, tended to be of higher histological grade than those (21) without efferent vascular invasion. Nuclear hyperchromatism and mitosis is the factor of importance to grading in this respect. This factor also differentiated between RE+ and RE- carcinomas in this material.

Breast Neoplasms↗
PubMed1981

Oestrogen receptor values and histological grade in human breast cancer.

Histological grading of 126 oestrogen receptor positive and 81 oestrogen receptor negative breast carcinomas, using the WHO system, showed that some tumours in all grades had high receptor values, others low. There was no correlation between the receptor values and histological grade. It is suggested that factors other than the degree of dedifferentiation of the tumour may be responsible for the consistent tendency for receptor negative tumours to be placed in a high histological grade.

Adult↗
PubMed1981

Time and place for sputum cytology in the diagnosis of lung cancer.

Despite ready access to medical care 91% of patients dying of lung cancer derived from a population of just under 400 000 are shown to have presented too late for other than palliative treatment. As the incidence and death rates from lung cancer in the district were very similar, few survivors can be expected. Morphological confirmation of the diagnosis was available in 96% of cases. The first positive morphological diagnosis was obtained from sputum cytology taken on admission in 69% of all cases and in 77% of those in whom there had been delay in diagnosis. More extensive use of this investigation on an outpatient basis is urged.

Aged↗
PubMed1981

A family with congestive cardiomyopathy.

In this family with congestive cardiomyopathy the lesion, a characteristic interstitial fibrosis with a high elastic tissue content, was defined at autopsy in 3 cases, and 3 further members may have been affected. The cases defined at autopsy all had long-standing arrhythmia and had suffered a cerebrovascular accident, probably secondary to endocardial fibroelastosis. The possibility that the myocardial cell changes may have been secondary to those in the interstitium is discussed. Ultrastructural X band changes were demonstrated 5 1/2 and 26 h postmortem.

Adult↗
PubMed1981

Implications of oestrogen receptor status in primary breast carcinoma to the role of adjuvant chemotherapy in node-negative cases.

Recurrence occurred earlier in a small group of patients with node-negative breast carcinoma with oestrogen receptor (ER)-negative tumours, than in those in whom the tumour contained ER. The difference, indicative of an intrinsic advantage of an ER-positive tumour, was not seen following adjuvant chemotherapy. This finding could be explained on the basis of changes in the immunological balance between host and tumour brought about by treatment.

Aged↗