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Biomedical subjects

F Gyntelberg

Publications and source records attributed to F Gyntelberg.

At least 109 records · Page 6Linked to original sources
PubMed1990

Computerized coordination ability testing.

Quantitative measurements of coordination ability were carried out on 76 women with a median age of 37, range 15 to 60. Spacing control, timing control and performance speed were recorded using newly developed computerized equipment, Catsys, presented in this paper. Twenty-three subjects were re-examined 2-3 months after the first measurements. A fair or even high degree of reproducibility of tests was found. Normal values for the entire group and correlation values for the re-examined group are presented. The results from this small study implies that the Catsys may be useful, e.g., in future clinical neurological practice of diagnostics and follow up on patients, in occupational medicine for detection of neurotoxic effects of various neurotoxic substances, in evaluation of drug effects and side effects and for testing people in occupations where normal coordination skills are absolutely necessary.

Adult↗
PubMed1989

Cross-sectional study of health effects of cryolite production.

A cross-sectional health study of 101 cryolite workers was performed, using spirometry and a questionnaire. Multiple regression analysis revealed a significant correlation between the index of smoking and a decrease in FEV1 (per cent). There was no significant correlation between work-related exposure and lung function. Many cryolite workers described a group of symptoms appearing after 15 to 30 min of heavy dust exposure: nausea, followed by epigastric pain with relief after spontaneous or provoked vomiting. Thirty-four (33.6 per cent) workers complained of nausea, vomiting or diarrhoea in relation to work, compared to 3.8 per cent of 1752 men participating in the Copenhagen Male Study.

Adult↗
PubMed1988

Health effects of toluene exposure.

The impact of industrial toluene exposure was assessed in 262 male employees of two Danish photographic printing plants. The study involved assessment of acute and chronic exposure based on a scoring system, standardised questions, measurement of blood pressure, pulmonary functions, and the plasma concentrations of urate, creatinine, creatine kinase, alanine-aminotransferase, FSH, LH, testosterone, sexual hormone binding globulin, thyroxine, triiodothyronine, and cortisole (following synacthen). The potentially confounding factors: age, weight, height, alcohol consumption and tobacco smoking were included in statistical analysis which showed that systolic blood pressure (p less than 0.01), P-P-FSH (p less than 0.001), dizziness (p less than 0.0001), decreased ability to concentrate (p less than 0.001), and dizziness during the past year (p less than 0.01) were correlated with the exposure score. Following six weeks without exposure, systolic blood pressure and P-ALAT decreased, the latter being correlated with the exposure score.

Adult↗
PubMed1987

Organic brain syndrome treated with oxiracetam. A double-blind randomized controlled trial.

In a 12-week double-blind study, oxiracetam (CGP 21690 E), a new nootropic drug, at a dose of 2.4 mg per day, was compared to placebo in the treatment of 106 middle-aged patients suffering from mild to moderate organic brain syndrome due to prolonged exposure to organic solvents. At the beginning of the study and after 12 weeks treatment, the patients underwent a battery of neuropsychological tests to determine their mental and memory functioning. A symptom questionnaire consisting of 21 items was rated pre-treatment, and improvement or worsening of any of the symptoms recorded monthly. At the end of the study a global evaluation was performed by the patients themselves, their relatives, the psychologist and the doctor. The code was not broken until the final writing of this paper. No statistically significant differences were observed between the treatment groups in any of the above-mentioned evaluations; neither were any differences in the neuropsychological tests performance observed. Thus, oxiracetam seems to have no effect in the treatment of organic brain syndrome.

Adult↗
PubMed1986

Acquired intolerance to organic solvents and results of vestibular testing.

Among 160 consecutive patients referred to the Clinic of Occupational Medicine, Rigshospitalet, for symptoms connected with exposure to organic solvents, 20 exhibited symptoms of acquired intolerance to minor amounts of organic solvents. Later, an additional 30 consecutive patients with symptoms of acquired intolerance were included, yielding a total of 43 men and 7 women. The characteristics of the clinical syndrome described are complaints of dizziness, nausea, and weakness after exposure to minimal solvent vapor concentrations. After having tolerated long-term occupational exposure to moderate or high air concentrations of various organic solvents, the patients became intolerant within a short period of time. Since dizziness was a frequent complaint, we tried to obtain a measure of the patients' complaints using vestibular tests. As a diagnostic test the combined vestibular tests had a sensitivity of 0.55 and a specificity of 0.87. No differences between patients with and without intolerance could be detected by the vestibular tests used. We conclude that acquired intolerance to organic solvents is a new but characteristic and easily recognizable syndrome, often with severe consequences for the patient's working ability.

Adult↗
PubMed1986

Demonstration of microorganisms and dust in schools and offices. An observational study of non-industrial buildings.

"The sick-building syndrome" (WHO) is reported with increasing intensity in non-industrial places of work, such as schools, kindergartens, and offices, all of which have a heavy load of traffic (people). The construction of these buildings (e.g. flat roofs) often leads to water damage with subsequent microbial growth. Further, reduced cleaning budgets in connection with the wide use of needle-felt carpets, as well as ventilation systems not regularly maintained, will lead to pollution by dust and microorganisms. A systematic registration of dust and microbial parameters has been carried out since 1980 in buildings with indoor climate complaints, in order to elucidate the possible influence of these factors.

Air Microbiology↗
PubMed1985

Human platelet 5-hydroxytryptamine concentration as a tool in prediction of solvent induced neurotoxic effects.

Many organic solvents are lipophilic and concentrate in lipid rich tissues e.g. nervous tissue, where they are known to induce toxic effects in humans, especially in the central nervous system. Changes in the presynaptic neurotransmitter metabolism may play a role in these effects. The platelet is proposed as an alternative human model for this complex in the investigation of such changes, especially regarding 5-hydroxytryptamine (5-HT). The platelet 5-HT concentration was measured in platelets isolated from exposed persons with diagnosed neurointoxication caused by exposure to organic solvents and compared to controls. No difference in the concentration was found. Instead of using the platelet 5-HT concentration in the prediction of neurotoxic effects, the platelet 5-HT uptake rate may be an alternative parameter. A specific and sensitive double isotope derivative technique for 5-HT measurements is described. A solvent induced reduction in the number of platelets/ml platelet rich plasma was found and is discussed.

Blood Platelets↗