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Biomedical subjects

F Guilbert

Publications and source records attributed to F Guilbert.

At least 73 records · Page 4Linked to original sources
PubMed1983

[The mobile tooth].

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Carcinoma, Squamous Cell↗
PubMed1983

Ameloblastic fibrosarcoma of the jaws--report of three cases. Clinico-pathologic, histoenzymological and ultrastructural study.

The ameloblastic fibrosarcoma is a rare variety of neoplasm. Three new cases reported here occurred within preexistent benign odontogenic tumors (ameloblastic fibroma or fibro-odontoma). These large, osteolytic tumors, spreading to adjacent soft parts, recurred after surgical treatment in two cases. One of them had a lethal course, with pleuro-pulmonary, mediastinal lymph node and hepatic metastases. Histologically, these sarcomas show a malignant mesenchymal component and few benign ameloblastic islands, which often disappear after one or several recurrences. Histoenzymologically, a high level of alkaline phosphatase and ATPase activities is always present, a feature not present in common fibrosarcomas. The ultrastructural study demonstrates, in analogy with odontogenic myxomas, clear cells provided with numerous microfilaments, secretory cells and also some fibroblasts and myofibroblast-like cells. In addition to these pleomorphic cells, a great number of peculiar granular cells with numerous lysosomal bodies were also found. The histogenesis of these tumors in unknown. Perhaps the epithelial component, being unable to assume its functions of organization, may initiate the malignant transformation of its odontogenic mesenchyme.

Acid Phosphatase↗
PubMed1983

[Salivary gland myoepithelioma. Histological, histoenzymological and ultrastructural study].

One case of myoepithelioma of the submandibular gland is reported. The tumor was composed of mixed spindle-shaped and plasmacytoid cells. The electron microscopy showed intracytoplasmic myofilaments, with variations in number and in repartition from one cell to another. Histoenzymologically, ATPasic and alkaline phosphatase activities could not be demonstrated in these poor differentiated myoid cells. Usually, the tumor has a good behavior. It represents a rare tumor (7 cases - 0,8% - in a retrospective study of 850 salivary gland tumors). Without demonstration of myofilaments by ultrastructural analysis, the diagnosis of such a tumor is very difficult. Taking into consideration new concepts about the myoepithelial cell, the histogenesis of this neoplasm is discussed.

Female↗
PubMed1983

[Hemangiopericytomas of the buccal cavity. Anatomoclinal and ultrastructural study. 9 cases].

Hemangiopericytoma, an unpredictable tumour, is not rare in the buccal cavity. Nine cases, most of which have been followed-up over a long period, show that, in this localisation, this neoplasm shows the unpredictable nature, though to a lesser degree (recurrences and metastases) of those situated in other parts of the body. Histological and ultrastructural analysis shows, apart from its characteristic perivascular features, much cellular polymorphism responsible for the diagnostic problems. A variety of cells, endothelial, fibroblastic and smooth muscle are observed next to the pericytes. The predominance of one or another cell type significantly affect the prognosis; immature forms with an endothelial predominance have a recurrent course, whilst fibrous forms have a much better prognosis. This diversity tends to support the histogenetic concept of one blastomatous cell responsible for the variable maturative possibilities.

Adolescent↗
PubMed1982

[Biopsy].

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Biopsy↗
PubMed1981

[Salivary gland cylindromas. Retrospective study of 65 cases (author's transl)].

A retrospective study of prognostic, clinical, and histological features in 65 cases of salivary gland cylindromas treated in the Hôpital Salpêtrière, Paris, was conducted. Vital prognosis was related to the initial size of the tumour, the presence of pain, and evidence of cellular anomalies or invasion of neighbouring structures on histological examination. Metastatic spread is related to peritumoural extension, and local recurrence has a prognostic value because of its relationship to later metastatic involvement.

Adult↗
PubMed1981

[Myeloma localized to the mandibuloparotid region (author's transl)].

Myeloma is a malignant hematopathy with multiple lesions, mainly in bones. The authors report a case in which the myeloma was present in the mandibuloparotid region only. The atypical nature and rarely observed location (mainly parotid) of the lesion raised diagnostic, prognostic, and therapeutic problems that were resolved by close cooperation with a team of hematologists. Therapy was by surgery only, in this particular case, because of the early stage of the lesion, but regular close surveillance is essential.

Aged↗
PubMed1981

[Malignant non-Hodgkin type lymphomas of the main salivary glands. A report on 11 cases (author's transl)].

Malignant non-Hodgkin type lymphomas (MNHL) are relatively frequent tumors but their localisation in the salivary glands is rarely reported in the published literature. The authors describe 11 such cases, seen in the stomatology Department of the Salpêtrière Hospital in Paris over a period of 4 years, in which the MNHL was located in the salivary tissues (2 purely glandular, 1 of the mixed type, and 8 extranodal tumors). Treatment by multiple chemotherapy and radiotherapy demonstrated that survival, whatever the anatomical type or even the histological form, was improved in relation to that observed with tumors in other locations.

Adult↗
PubMed1981

[Primary mandibular condyle tumors. Osteomas, chondroma, fibrosarcoma, giant cell tumor (author's transl)].

Six out of 11 cases of primary condylar tumors treated in the Department of stomatology and Maxillofacial Surgery were analyzed. They included 3 patients with osteomas, and one case each of fibrosarcoma, chondroma, and multinucleated giant cell tumor. Typical signs were lateral displacement of the mandible (2 cases), reduction in the buccal opening (3 cases), and pain (3 cases) and swelling (3 cases) in the pretragal region. Swelling is never observed with osteomas, which develop antero-internally. The presence of the tumors was confirmed by radiological examination in all cases. Usual treatment is condylectomy, by means of C. Hosxés approach, confirmation of diagnosis requiring pathological examinations.

Adolescent↗
PubMed1981

[Parotid cystadenolymphomas : histo-enzymological and ultrastructural study in 6 cases (author's transl)].

Histo-enzymological and ultrastructural studies in 6 cases of cystadenolymphoma were able to confirm the marked metabolic activity of the oncocytic cells, which from the major part of these tumours. The oncocytes demonstrate greatly enhanced enzymatic activity, particularly of those enzymes concerned with oxydative metabolism and the diaphorases. Electron microscopy of the oncocytes shows that they are filled with mitochondria of very varied size and form, sometimes associated with the presence of several intracytoplasmic crystalloids. The second, lymphoplasmocytic component of these tumours present no particular morphological features.

Adenolymphoma↗
PubMed1981

[Mandibular condyle metastasis : report of three cases (author's transl)].

Three cases of mandibular condyle metastasis of particular interest are reported: -- In two out of the three cases they were detected early enough for the primary tumour to be diagnosed; -- they all presented with articular symptoms; -- all three were treated surgically by excision of the condyles. Diagnosis was confirmed by histological examination, a rare event when mandibular metastasis are concerned, these usually being diagnosed after the primary tumour and then irradiated without histological proof. Primary tumours were respectively bronchial, pancreatic, and mammary.

Adenocarcinoma↗