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Biomedical subjects

F Grisoli

Publications and source records attributed to F Grisoli.

At least 181 records · Page 10Linked to original sources
PubMed1980

Prolactin secreting adenoma in 22 men.

The authors report on 22 men with a prolactin secreting adenoma. Clinical symptomatology included associated signs of tumoral compression with varying degrees of hypogonadism. Endocrinological evaluation disclosed hyperprolactinemia in all cases but one, and hypopituitarism in 10 of 22 cases. Of the 22 patients, 21 underwent transsphenoidal microsurgery (two of whom underwent a second procedure by the infrafrontal approach) and in one case surgery was performed by the infrafrontal route. Diagnosis was confirmed by immunocytochemical evaluation of tumoral tissue. Prolactin levels returned to normal in 32% of cases after operation and became normal after complementary bromocriptine therapy in 54.5% of cases. However, normal prolactin secretion was not consistently accompanied by a return to normal of gonadotropin regulation. In three patients radiotherapy was not effective. The latter treatment should be limited to the very rare cases of postoperative resistance to bromocriptine.

Adenoma↗
PubMed1980

[Prolactin adenomas in children (author's transl)].

During the last four years 12 Prolactin (PRL) secreting adenomas whose first clinical manifestation appeared before the age of 15 years have been studied. The first signs were a decreased growth rate and arrest of pubertal development in 4 girls and 2 boys in whom the adenoma occurred before or during puberty. In the other six cases (5 girls and 1 boy) the first signs were secondary amenorrhea and galactorrhea in girls and in the boy gynecomastia followed by galactorrhea. Symptoms of the tumour (headaches, and visual disturbances) were almost invariable (11/12) and led to the diagnosis in two cases. Plasma PRL levels were always elevated (80 to more than 5,000 ng/ml) and did not rise in response to TRH. 11 out of 12 were large tumours and pituitary tomography showed that tumour was circumscribed in five cases and invasive in the other seven. The prognosis is related to the short term outcome. The condition may be cured by surgery only (25% cases only) or by surgery and bromocriptine.

Adenoma↗
PubMed1979

[Pituitary microadenoma of Cushing's disease. Course following transsphenoidal excision. Four cases (author's transl)].

Transsphenoidal microsurgery was performed in four patients with a pituitary microadenoma who presented Cushing's disease. Preoperative features were the following: 1) Clinical and laboratory signs of hypercortisolism 2) No radiological evidence of an adrenal tumor 3) Normal or increased ACTH plasma levels 4) Sellar tomograms suggesting the presence of a pituitary microadenoma in only one case. Postoperative outcome after 3 to 30 months follow-up showed persistence or even improved reactivity of the various pituitary functions and especially the early occurence of corticotropin deficiency in all 4 patients. This isolated deficiency regressed spontaneously after 6 and 12 months (2/4 cases). Twenty-four hour studies of ACTH and cortisol profiles and dexamethasone suppression as well as response to metyrapone confirmed the resumption of physiological corticotropin regulation.

Adenoma↗
PubMed1979

[Immunocytochemical similarities between basophilic and chromophobe pituitary adenomas. Light and electron microscopic study of 13 cases (author's transl)].

ACTH, beta MSH, beta LPH, beta endorpSin, leucine and methionine enkephalin activities were tested in four Cushing pituitary basophilic adenomas and nine "chromophobe" adenomas with immunoperoxidase methods. The antisera gave various positive reactions in both of these groups. ACTH, alpha MSH and enkephalins were predominant. The reason why these hormones are clinically silent in "chromophobe" or, even, basophilic adenomas is still to be elucidated.

Adenoma, Basophil↗
PubMed1978

[Pubertal prolactin adenoma. Eight cases (author's transl)].

Among 70 operated patients with a histologically verified prolactin secreting adenoma, 8 cases (7 girls, 1 boy) presented the onset of clinical signs before, during or immediately after puberty. Two different clinical syndromes were detected. In the younger patient group (4 cases), the first clinical signs at the onset of puberty were arrest of both growth and pubertal development. In the four remaining causes where in puberty had been achieved, primary-secondary amenorrhea and galactorrhea were observed. Sellar tomograms revealed the presence of invasive adenoma in 3 patients, and circumscribed (enclosed) adenoma in 5 cases. In 7 cases, surgical management was by the transsphénoïdal approach, while one patient underwent subfrontal surgery. Post-operative results were a function of tumour size. In the seven patients having undergone transsphenoïdal surgery, 4 patients displayed a return to normal prolactin function. In the remaining patients, post-operative management was conducted with bromocriptin and without radiotherapy.

Adenoma↗
PubMed1978

[Transsphenoidal surgery in hypersecreting pituitary tumors: endocrine follow-up (author's transl)].

Among 18 patients suffering prolactin adenoma and 16 acromegalic patients, plasma levels of PRL and HGH respectively returned to normal vlues (PRL = 9 +/- 2 ng/ml HGH = 4.2 +/- 0.8 ng/ml) immediately after selective removal of the pituitary adenoma by transsphenoïdal route. In all cases tumoral symptoms were reduced. Menses were recovered 36 +/- 5 days after surgery in all patients with prolactin adenoma. Pregnancy succeeded in nine of these women. Per-operative studies of HGH and PRL plasma variations proved to be of good prognostic value. The evaluation of the pituitary functions was performed before and after surgery. In no case pituitary deficiency occured after treatment. Furthermore the regulation of somatotropic and prolactin functions have been documented by the use of different provocative tests before and after treatment. They allow discussion of the pathogenecity of these hypersecreting tumors.

Adenoma↗
PubMed1977

[Surgical results in prolactin-secreting pituitary adenomas (a propos of 40 personal observations)].

The authors present a serie of 40 histologically verified prolactin secreting adenomas. Thirty-four women and six men were explored using the usual techniques and operated by the transphenoidal approach with biological follow-up 3, 6 and 12 months post-operatively. Results were a function of tumor size and invasive potential. Although amelioration of the tumoral syndrome always resulted, fonctional and biological normalization were inconstant. Complementary anti-prolactin treatment (C.B. 154) was begun in the non-normalized patients, especially in the cases of invasive adenoma. --Normalization was achieved in 95% of enclosed adenomas, --In 61% of invasion adenomas. In those patients normalized following surgery a return to normal rythmic prolactin secretion was observed.

Adenoma↗
PubMed1977

Extradural hematomas in infants.

This study reports 19 cases of extradural hematomas in infants for their relative frequency in head injury of children, their clinical findings, their particular evolution and the therapeutic problems specific to this age.

Carotid Arteries↗
PubMed1976

[Olfactory esthesioneurocytoma: ultrastructural study of a case (author's transl)].

One case of malignant tumour of the left nasal cavity is reported in a woman 56 year old, affected by the disease 24 years. Numerous recurrences appeared and various histological diagnoses were performed. At the last surgery, the tumour invaded the ethmoid and was a typical olfactory esthesioneurocytoma. By electron microscopy, mature ganglion cells with dense cored vesicles (neurosecretory granules) were densely packed. Neuritic processes with microtubules were rarely normal in size and their content was most often abnormal; furthermore dystrophic axons were noted in great number.

Axons↗
PubMed1975

[Transsphenoidal hypophysectomy in metastasizing breast cancers. Experience from 160 cases].

160 patients suffering from advanced metastatic cancer of the breast had transsphenoidal open surgical hypophysectomy. Mortality (1,8 p.cent) and morbidity were extremely low in view of the general conditions of the patients. Immediate relief of pain due to bone metastasis was obtained in 92 p.cent of cases. Such results emphasized the important point of achieving total hypophysectomy.

Adult↗
PubMed1975

Extradural hematomas in children. 104 cases.

The authors have studied the clinical features of 104 extradural hematomas in children. The frequency of this complication seems rather high and its severity undeniable. 17 cases were observed in newborns and 2 cases were localized in the posterior fossa. From a clinical point of view, 57% of the children had no disturbances in consciousness at the time of the injury, and 7% had no disturbances at anytime. A lucid interval was found in 68% of the cases, and this was less than 24 h in 60% of the cases. In 19% of the cases there was no skull fracture. Angiography allowed correct diagnosis and a better choice of the surgical technique. The hematoma was distinctly localized in 59 children, whereas it was widespread in 45, meaning that, excepting the coronal suture, the cranial sutures do not limit the spreading of an extradural hematoma. For treatment the authors prefer a bone flap with four or five holes (90 operations). The results are rather unsatisfactory. 18 patients died and in 21 (7.2%) the motor sequelae were the most important complications.

Accidents, Traffic↗